Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Roger K. Sunahara"'
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract G protein-coupled receptors (GPCRs) within the same subfamily often share high homology in their orthosteric pocket and therefore pose challenges to drug development. The amino acids that form the orthosteric binding pocket for epinephrine a
Externí odkaz:
https://doaj.org/article/06de6af761474c2b9a90d90838043ba7
Autor:
Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne Stößel, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka, Roger K. Sunahara, Xiangyu Liu, Peter Gmeiner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/a33640b5b5bf4ee68a4f3543dfc0d68f
Autor:
Libin Ye, Chris Neale, Adnan Sljoka, Brent Lyda, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Régis Pomès, Angel E. García, Oliver P. Ernst, Roger K. Sunahara, R. Scott Prosser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
G protein-coupled receptors (GPCRs) are membrane receptors and are important drug targets, whose regulation by cations is poorly understood. Here authors use NMR to elucidate effects of cations on functional states of the GPCR, adenosine A2Areceptor
Externí odkaz:
https://doaj.org/article/25e0679825f24b93877531f883a95c68
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract FRET and BRET approaches are well established for detecting ligand induced GPCR-G protein interactions in cells. Currently, FRET/BRET assays rely on co-expression of GPCR and G protein, and hence depend on the stoichiometry and expression le
Externí odkaz:
https://doaj.org/article/246552c8efa54c19bc36a88af7a47811
Autor:
Shuya Kate Huang, Louis-Philippe Picard, Rima S. M. Rahmatullah, Aditya Pandey, Ned Van Eps, Roger K. Sunahara, Oliver P. Ernst, Adnan Sljoka, R. Scott Prosser
Publikováno v:
Nature Structural & Molecular Biology. 30:502-511
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a33be834828356986fd28531a072be66
https://doi.org/10.1038/s41594-023-00957-1
https://doi.org/10.1038/s41594-023-00957-1
Autor:
Yonghoon Kwon, Sohum Mehta, Mary Clark, Geneva Walters, Yanghao Zhong, Ha Neul Lee, Roger K. Sunahara, Jin Zhang
Publikováno v:
Nature
G protein-coupled receptors (GPCRs), the largest family of signaling receptors, as well as important drug targets, are known to activate extracellular-signal-regulated kinase (ERK), a master regulator of cell proliferation and survival(1). However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8424c3d5f643fa27b52e961ad5a998b4
https://doi.org/10.1038/s41586-022-05343-3
https://doi.org/10.1038/s41586-022-05343-3
Autor:
Eirini P. Papapetrou, Gene W. Yeo, Roger K. Sunahara, Lewis Silverman, Julie Teruya-Feldstein, Ernesto Guccione, Samuel S. Park, Malgorzata Olszewska, Andriana G. Kotini, Daniel Mayer, Shailee Vora, Emily C. Wheeler
Supplementary table from Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30afb4e0c3984c29c10ed900dd8122bf
https://doi.org/10.1158/2159-8290.22541095
https://doi.org/10.1158/2159-8290.22541095
Autor:
Eirini P. Papapetrou, Gene W. Yeo, Roger K. Sunahara, Lewis Silverman, Julie Teruya-Feldstein, Ernesto Guccione, Samuel S. Park, Malgorzata Olszewska, Andriana G. Kotini, Daniel Mayer, Shailee Vora, Emily C. Wheeler
Mutations in splicing factors (SF) are the predominant class of mutations in myelodysplastic syndrome (MDS), but convergent downstream disease drivers remain elusive. To identify common direct targets of missplicing by mutant U2AF1 and SRSF2, we perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb1f354c504bf63b6349018446a9859
https://doi.org/10.1158/2159-8290.c.6549553
https://doi.org/10.1158/2159-8290.c.6549553
Autor:
Eirini P. Papapetrou, Gene W. Yeo, Roger K. Sunahara, Lewis Silverman, Julie Teruya-Feldstein, Ernesto Guccione, Samuel S. Park, Malgorzata Olszewska, Andriana G. Kotini, Daniel Mayer, Shailee Vora, Emily C. Wheeler
Supplementary Data from Integrative RNA-omics Discovers GNAS Alternative Splicing as a Phenotypic Driver of Splicing Factor–Mutant Neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7176726856f3aa21a183a8b8ef8c65
https://doi.org/10.1158/2159-8290.22541104
https://doi.org/10.1158/2159-8290.22541104
Publikováno v:
eLife, Vol 7 (2018)
The intrinsic efficacy of orthosteric ligands acting at G-protein-coupled receptors (GPCRs) reflects their ability to stabilize active receptor states (R*) and is a major determinant of their physiological effects. Here, we present a direct way to qu
Externí odkaz:
https://doaj.org/article/8d3cf488daee406e85d03caf5555d460