Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Roger John Griffin"'
Autor:
Roger John Griffin, Martin E.M. Noble, James M. McDonnell, Anna Watson, Jane A. Endicott, Stuart J. Kemp, Bernard T. Golding, Lynette A. Smyth, Christiane Riedinger, Eric Valeur, Ian R. Hardcastle
Publikováno v:
Journal of the American Chemical Society. 130:16038-16044
In this study we present a method for defining the binding modes of a set of structurally related isoindolinone inhibitors of the MDM2-p53 interaction. This approach derives the location and orientation of isoindolinone binding, based on an analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed7dcc45f7bde48407bbf906de49c5
https://doi.org/10.1021/ja8062088
https://doi.org/10.1021/ja8062088
Autor:
Robert Almassy, Theodore J. Boritzki, Karen A. Maegley, Bernard T. Golding, Suzanne Kyle, Huw D. Thomas, Stephen E. Webber, Tikhe Jayashree Girish, A. Hilary Calvert, Nicola J. Curtin, Xiao-Hong Yu, Jianke Li, Zdenek Hostomsky, Roger John Griffin, David Richard Newell, Anne Ekkers, Cathy Zhang, Robert Arnold Kumpf, Christopher R. Calabrese, Lan-Zhen Wang
Publikováno v:
Journal of Medicinal Chemistry. 47:5467-5481
The design, synthesis, and biological evaluation of potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1) are reported. A novel series of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones were designed using a combination of protein structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82337c486d0f3a91ab902b0d1cdaeec
https://doi.org/10.1021/jm030513r
https://doi.org/10.1021/jm030513r
Autor:
Yi Chen, Lan-Zhen Wang, J Bentley, AE Gibson, Philip J. Jewsbury, Bernard T. Golding, D.J. Pratt, FT Boyle, H.J. Whitfield, Mesguiche, Martin E.M. Noble, J Menyerol, Jane A. Endicott, Ian R. Hardcastle, Roger John Griffin, David Richard Newell, C.E. Arris, Nicola J. Curtin
Publikováno v:
Journal of Medicinal Chemistry. 47:3710-3722
The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has been employed as the lead in a structure-based drug discovery program resulting in the discovery of the potent CDK1 and -2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1147603822315847f8cd9ae98536ed81
https://doi.org/10.1021/jm0311442
https://doi.org/10.1021/jm0311442
Autor:
Bernard T. Golding, Laurent Rigoreau, Graeme Cameron Murray Smith, Jonathan James Hollick, Niall M. B. Martin, Ian R. Hardcastle, Roger John Griffin, Caroline Richardson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3083-3086
6-aryl-2-morpholin-4-yl-4H-pyran-4-ones and 6-aryl-2-morpholin-4-yl-4H-thiopyran-4-ones were synthesised and evaluated as potential inhibitors of the DNA repair enzyme DNA-dependent protein kinase (DNA-PK). Several compounds in each series exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561d1dc0b02f4bcdacf252bd459ab0cc
https://doi.org/10.1016/s0960-894x(03)00652-8
https://doi.org/10.1016/s0960-894x(03)00652-8
Autor:
Huw D. Thomas, Anne Ekker, Stephen E. Webber, Christopher R. Calabrese, Nicola J. Curtin, Robert Almassy, Karen A. Maegley, Rena N. Mansour, Lan-Zhen Wang, Robert Arnold Kumpf, A. Hilary Calvert, Cathy Zhang, Scott E. Zook, Jianke Li, Bernard T. Golding, Tikhe Jayashree Girish, Xiao-Hong Yu, Suzanne Kyle, Zdenek Hostomsky, Theodore J. Boritzki, Thoresen Lars Henrik, David Richard Newell, Kanyin E. Zhang, Stacie S. Canan Koch, Roger John Griffin
Publikováno v:
Journal of Medicinal Chemistry. 45:4961-4974
A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1), and the activity and physical properties have been characterized. The new structural classes, 3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec741e627bfb818de6119c89a2082ae7
https://doi.org/10.1021/jm020259n
https://doi.org/10.1021/jm020259n
Autor:
Nicola J. Curtin, Bernard T. Golding, Philip J. Jewsbury, E.A Sausville, David Richard Newell, Alison M. Lawrie, AE Gibson, A.H Calvert, W. Yu, Roger John Griffin, R Schultz, FT Boyle, CE Arris, Louise N. Johnson, S Grant, Elspeth F. Garman, Martin E.M. Noble, Jane A. Endicott
Publikováno v:
Journal of Medicinal Chemistry. 43:2797-2804
Substituted guanines and pyrimidines were tested as inhibitors of cyclin B1/CDK1 and cyclin A3/CDK2 and soaked into crystals of monomeric CDK2. O6-Cyclohexylmethylguanine (NU2058) was a competitive inhibitor of CDK1 and CDK2 with respect to ATP (Ki v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4184b36ea5cd3d087a25be12fd527ab0
https://doi.org/10.1021/jm990628o
https://doi.org/10.1021/jm990628o
Autor:
Pete Smith, A. Hilary Calvert, HC Barlow, Roger John Griffin, Karen J. Bowman, Bernard T. Golding, David Richard Newell, Nicola J. Curtin, Peter J. Loughlin, B Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:585-589
The synthesis and biological evaluation of potent 4,8-dibenzylaminopyrimidopyrimidine nucleoside transport inhibitors, with reduced binding to α1-acid glycoprotein, is reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca1857523197dab9de1feeeeee30629
https://doi.org/10.1016/s0960-894x(00)00053-6
https://doi.org/10.1016/s0960-894x(00)00053-6
Autor:
Bernard T. Golding, Mark R. J. Elsegood, William Clegg, Andrew Mitchinson, Roger John Griffin
Publikováno v:
Scopus-Elsevier
Methods are described for the preparation of derivatives of the polyamines 1,4-diaminobutane (putrescine) and N-(3-aminopropyl)-1,4-diaminobutane (spermidine) in which a particular amino group is modified with, e.g., a guanidino function. Specific am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683626582ffac5251296cc69b19b0ca2
https://doi.org/10.1039/a806355i
https://doi.org/10.1039/a806355i
Autor:
Bernard T. Golding, Roger John Griffin, Annalisa Bertoli, Tristan Reuillon, Miller Duncan Charles
Publikováno v:
ChemInform. 44
The protection-deprotection strategy comprises reaction of phenols (I) with sulfonylbis(methylimidazole) (II) to provide aryl imidazole sulfonates (III), which are activated by reaction with trimethyloxonium tetrafluoroborate, before further reaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6976423695ee2dec581a68a1ec9ea6f
https://doi.org/10.1002/chin.201308083
https://doi.org/10.1002/chin.201308083
Autor:
Daniel L. Rathbone, Simon B Bedford, Roger John Griffin, Malcolm F. G. Stevens, Charmaine Paulina Quarterman, John A. Slack
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:157-160
Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ff6b9580219e5e2f749104c04341b4
https://doi.org/10.1016/0960-894x(95)00580-m
https://doi.org/10.1016/0960-894x(95)00580-m