Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Roger J.S. Preston"'
Autor:
Niamh O'Regan, Kristina Gegenbauer, Eimear M. Gleeson, Kenji Fukudome, Jamie M. O'Sullivan, Clive Drakeford, Niall Dalton, Alain Chion, Teresa M. Brophy, Owen P. Smith, Roger J.S. Preston, James S. O'Donnell
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Externí odkaz:
https://doaj.org/article/915af75fe6c7477c8bc22b31031e043d
Autor:
Mark M. Hughes, Alexander Hooftman, Stefano Angiari, Padmaja Tummala, Zbigniew Zaslona, Marah C. Runtsch, Anne F. McGettrick, Caroline E. Sutton, Ciana Diskin, Melissa Rooke, Shuhei Takahashi, Srinivasan Sundararaj, Marco G. Casarotto, Jane E. Dahlstrom, Eva M. Palsson-McDermott, Sinead C. Corr, Kingston H.G. Mills, Roger J.S. Preston, Nouri Neamati, Yiyue Xie, Jonathan B. Baell, Philip G. Board, Luke A.J. O’Neill
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 151-161.e5 (2019)
Summary: The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyropto
Externí odkaz:
https://doaj.org/article/655fe3fa8e5148bd966bc89b672d9785
Autor:
Eimear M. Gleeson, James S. O’Donnell, Emily Hams, Fionnuala Ní Áinle, Bridget-Ann Kenny, Padraic G. Fallon, Roger J.S. Preston
Publikováno v:
Haematologica, Vol 99, Iss 1 (2014)
Vitamin K-dependent proteases generated in response to vascular injury and infection enable fibrin clot formation, but also trigger distinct immuno-regulatory signaling pathways on myeloid cells. Factor Xa, a protease crucial for blood coagulation, a
Externí odkaz:
https://doaj.org/article/91f0053230c64f8b85d081993a77f96e
Autor:
Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G. Fallon, Roger J.S. Preston, John Gormley, Kevin Ryan, Niamh M. O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P. Crowley, Susan I. O'Shea, Birgit M. Reipert, Jill M. Johnsen, Steven W. Pipe, Jorge Di Paola, Peter L. Turecek, James S. O'Donnell
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:1123-1134
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:453-455
Autor:
Helen Fogarty, Soracha E. Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M. O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Ross I. Baker, Cliona Ni Cheallaigh, James S. O'Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2429-2438
Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute
Autor:
Aisling M. Rehill, Gemma Leon, Sean McCluskey, Ingmar Schoen, Yasmina Hernandez-Santana, Stephanie Annett, Paula Klavina, Tracy Robson, Annie M. Curtis, Thomas Renné, Seamus Hussey, James S. O’Donnell, Patrick T. Walsh, Roger J.S. Preston
Myeloid cell metabolic reprogramming is a hallmark of inflammatory disease, however, its role in inflammation-induced hypercoagulability is poorly understood. Using novel myeloid cell-based global haemostasis assays and murine models of immunometabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d51e3d197882398705f001c6b46a1a3
https://doi.org/10.1101/2023.04.20.537683
https://doi.org/10.1101/2023.04.20.537683
Autor:
Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, Claire Comerford, Ellie Karampini, Hanna Englert, Mary Byrne, Colm Bergin, Jamie M. O’Sullivan, Ignacio Martin‐Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Dennis McGonagle, Cliona Ni Cheallaigh, Ross I. Baker, Thomas Renné, Soracha E. Ward, James S. O’Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Persistent symptoms including breathlessness, fatigue, and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this “long COVID” syndrome remain unknown. Ho
Publikováno v:
Clinical science (London, England : 1979). 136(24)
Inflammatory disease is often associated with an increased incidence of venous thromboembolism in affected patients, although in most instances, the mechanistic basis for this increased thrombogenicity remains poorly understood. Acute infection, as e
Publikováno v:
Current opinion in hematology. 29(5)
To provide an overview of the state-of-the-art in protein C (PC) pathway research.The PC pathway is crucial for maintaining hemostasis to prevent venous thromboembolism. This is evident from genetic mutations that result in impaired PC pathway activi