Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Roger J. Snow"'
Autor:
Mohammed A. Kashem, Stanley Kugler, Lida Soleymanzadeh, Yunlong Zhang, Jeffery B. Madwed, Xin Guo, Kirrane Thomas M, Roger J. Snow, Alan David Swinamer, Jennifer Burke, Margaret M. O’Neill, Stephen J. Boyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:738-742
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a6710f1742d2d831246aeb83ce910
https://doi.org/10.1016/j.bmcl.2011.10.029
https://doi.org/10.1016/j.bmcl.2011.10.029
Autor:
Zhaoming Xiong, Stephen J. Boyer, Lida Soleymanzadeh, Stanley Kugler, John Westbrook, Yunlong Zhang, Anil Kumar Padyana, Jennifer Burke, Jeffrey B. Madwed, Derek Cogan, Alan David Swinamer, Chris Sarko, Mohammed A. Kashem, Frank M. DiCapua, Kirrane Thomas M, Amy Gao, Roger J. Snow, Xin Guo, Margaret M. O’Neill
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:733-737
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were identified through high throughput screening. An RSK crystal structure and exploratory SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280d6ba59ece0c6b1b215b764b652158
https://doi.org/10.1016/j.bmcl.2011.10.030
https://doi.org/10.1016/j.bmcl.2011.10.030
Autor:
Steven Kerr, Charles L. Cywin, Frank H. Büttner, Frank Wu, Mohammed A. Kashem, Scott Jakes, Zofia Paw, Roger J. Snow, Erick R. R. Young, Eugene R. Hickey, Stanley Kugler, Paul Kaplita, Cheng-Kon Shih, Rhonda Chen, Anthony S. Prokopowicz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3235-3239
Two closely related scaffolds were identified through an uHTS campaign as desirable starting points for the development of Rho-Kinase (ROCK) inhibitors. Here, we describe our hit-to-lead evaluation process which culminated in the rapid discovery of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2d691a0169d6458e981f329be40c8b
https://doi.org/10.1016/j.bmcl.2010.04.070
https://doi.org/10.1016/j.bmcl.2010.04.070
Autor:
Walter Davidson, Scott Jakes, Susan Lukas, Gregory W. Peet, Christopher Pargellis, Roger J. Snow, Rachel R. Kroe, Lee Frego, Mark E. Labadia, Brian Werneburg, Christine A. Grygon
Publikováno v:
Biochemistry. 43:11658-11671
A novel inhibitor of p38 mitogen-activated protein kinase (p38), CMPD1, identified by high-throughput screening, is characterized herein. Unlike the p38 inhibitors described previously, this inhibitor is substrate selective and noncompetitive with AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d621e78115b26c6a3eff01628a61a09
https://doi.org/10.1021/bi0495073
https://doi.org/10.1021/bi0495073
Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase
Autor:
Maret Panzenbeck, Mario G. Cardozo, Robert M. Tolbert, Jeffrey D. Peterson, Susan Lukas, Stephen Jacober, Robert J. Eckner, Gregory W. Peet, Anthony S. Prokopowicz, Carl A. Busacca, Suresh R. Kapadia, Scott Jakes, Tina Morwick, Roger J. Snow, Rosemarie Sellati, Yong Dong, Matt Aaron Tschantz, Neil Moss
Publikováno v:
Journal of Medicinal Chemistry. 45:3394-3405
An imidazo[4,5-h]isoquinolin-7,9-dione (1) was identified as an adenosine 5'-triphosphate competitive inhibitor of lck by high throughput screening. Initial structure-activity relationship studies identified the dichlorophenyl ring and the imide NH a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcb66ed0ff6ce36eb079aaec851fb78a
https://doi.org/10.1021/jm020113o
https://doi.org/10.1021/jm020113o
Autor:
Roger J. Snow, Randall W. Barton, Ulrich L. Günther, Simon J. Coutts, William W. Bachovchin, James L. Sudmeier
Publikováno v:
Magnetic Resonance in Chemistry. 33:959-970
L-Val-L-boroPro, a potent DP IV (CD26) inhibitor, and its non-inhibitory diastereomer L-Val-D-boroPro, were studied by 1D 1H and 11H NMR and by 2D 1H NMR methods in aqueous solution. Complete 1D 1H NMR fine structures were computer analyzed to obtain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4d9533247c1d399ffddce9e5c82719
https://doi.org/10.1002/mrc.1260331204
https://doi.org/10.1002/mrc.1260331204
Autor:
Terence A. Kelly, Randall W. Barton, Simon J. Coutts, Dorothy M. Freeman, William G. Gutheil, Scot J. Campbell, Charles A. Kennedy, Roger J. Snow, William W. Bachovchin
Publikováno v:
Journal of the American Chemical Society. 116:10860-10869
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::180eea2eb64fcbc53fbb5b70744dbbff
https://doi.org/10.1021/ja00103a002
https://doi.org/10.1021/ja00103a002
Two efficient methods for the cleavage of pinanediol boronate esters yielding the free boronic acids
Publikováno v:
Tetrahedron Letters. 35:5109-5112
Two synthetic methods for the preparation of boronic acids from their corresponding pinanediol boronate esters are reported. The key to success of the procedures relies on removal of the liberated pinanediol from the reaction mixture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fcbf9ddc33d59d23b205ebd361e79f1
https://doi.org/10.1016/s0040-4039(00)77040-7
https://doi.org/10.1016/s0040-4039(00)77040-7
Autor:
Akalushi Muthukumarana, Frank M. DiCapua, Stanley Kugler, Fariba Soleymanzadeh, Glenn A. Reinhart, Rong Rhonda Chen, Margaret M. O’Neill, Jennifer Burke, Ryan M. Fryer, Roger J. Snow, Suzanne Nodop Mazurek, Jeffrey B. Madwed, Kirrane Thomas M, Roger M. Dinallo, Paul C. Harrison, Mohammed A. Kashem, Stephen J. Boyer, James D. Smith, Yunlong Zhang, Kyle E. Harrington, Xin Guo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 340(3)
We previously reported the discovery of a novel ribosomal S6 kinase 2 (RSK2) inhibitor, (R)-5-Methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a] indole-8-carboxylic acid [1-(3-dimethylamino-propyl)-1H-benzoimidazol-2-yl]-amide (BIX 02565), with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1053be1edf09cbfc285b06ebeacf7b3c
https://pubmed.ncbi.nlm.nih.gov/22128344
https://pubmed.ncbi.nlm.nih.gov/22128344
Publikováno v:
Tetrahedron. 49:1009-1016
A method for the preparation and resolution of the pinanediol ester of prolineboronic acid is described. The method takes advantage of the ease of both the lithiation and the reduction of boc-pyrrole to generate the desired compound rapidly and in hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f837ab7ed00af510c1d1b9666ee811de
https://doi.org/10.1016/s0040-4020(01)86281-5
https://doi.org/10.1016/s0040-4020(01)86281-5