Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Roger J. Ponsford"'
Autor:
J. Sydney Davies, Michael Anthony Harris, David J. Merrikin, Richard Keith Anderson, Roger J. Ponsford, Trevor J. Grinter, Carol F. Smith, Christina A. Mitchell, Suzanne C. Cosham, Andrew V. Stachulski, Pauline C. A. Chapman
Publikováno v:
The Journal of Antibiotics. 46:331-342
Syntheses are described for penicillins (4b approximately 4i, 5a and 5b) which possess a 6 beta-(2-heteroaryl-3-substituted)-propenamido side-chain of fixed geometry. In vitro results for these compounds against a range of Gram-positive and Gram-nega
Autor:
Roger J. Ponsford, J. Lowther, A. J. Eglington, P. Brown, S. C. Cosham, R. L. Elliot, D. J. Merrikin, P. C. A. Chapman, J. V. Syms, S. H. Calvert, J. D. Hinks, Michael J. Pearson, M. A. Harris
Publikováno v:
ChemInform. 22
Autor:
J. D. Hinks, Richard L. Elliot, Michael J. Pearson, Suzanne C. Cosham, A. John Eglington, John Lowther, John V. Syms, Pauline C. A. Chapman, Roger J. Ponsford, Michael Anthony Harris, David J. Merrikin, Pamela Brown, Stephen H. Calvert
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :881-891
A series of (Z)-2-alkyloxyimino-2-(2-aminothiazol-4-yl)acetamidopenicillins has been prepared. New methodology has been developed to prepare tertiary alkyl oximes. High stability to β-lactamases and potent antibacterial activity have been achieved a
Publikováno v:
The Journal of antibiotics. 46(2)
Publikováno v:
Tetrahedron Letters. 24:2693-2696
Investigation into the chemistry of benzyl clavulanate under a variety of reaction conditions has led to acid catalysed one-step conversion to ether and thioether derivatives. Generation of nitrogen-containing displacement products proceeds via the r
Autor:
Roger J. Ponsford, Stephen Christopher Finch, Terence C. Smale, Michael J. Pearson, Clive Leslie Branch, Peter H. Milner, Angela W. Guest, Michael J. Basker
Publikováno v:
The Journal of Antibiotics. 39:1788-1791
Publikováno v:
Tetrahedron Letters. 21:5071-5074
3-(2-Pyrimidinylthio-) substituted olivanic acid analogues, with and without a C-6 hydroxyethyl substituent, have been synthesised in high yield using an intramolecular Wittig reaction followed by deprotection to afford zwitterions with high antibact
Autor:
Clive Leslie Branch, Stephen Christopher Finch, Michael J. Pearson, Roger J. Ponsford, Angela W. Guest, Peter H. Milner, Terence C. Smale, Arun C. Kaura
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :45-55
The preparation of novel antibacterially active 7α-formamido cephalosporins from the corresponding 7α-(methylthio) analogues by mercury (II)-mediated displacement with ammonia and subsequent formylation is described. The amine (2), a versatile inte
Autor:
Peter H. Milner, Brian Slocombe, A. W. Guest, Terence C. Smale, Roger J. Ponsford, Andrew V. Stachulski, Frank P. Harrington, Michael J. Basker
Publikováno v:
The Journal of Antibiotics. 39:1498-1501
Publikováno v:
Journal of Antimicrobial Chemotherapy. 18:399-405
BRL 20330 is the o-methyl phenyl ester of temocillin which is well absorbed after oral administration and converted to temocillin in the body. BRL 20330 was administered to healthy subjects in a three-part cross-over study with single doses equivalen