Zobrazeno 1 - 10
of 693
pro vyhledávání: '"Roger J. Packer"'
Autor:
Debasish Roy, Bavani Subramaniam, Wai Chin Chong, Miriam Bornhorst, Roger J. Packer, Javad Nazarian
Publikováno v:
Cancers, Vol 16, Iss 7, p 1361 (2024)
Pediatric cancers are the leading cause of disease-related deaths in children and adolescents. Most of these tumors are difficult to treat and have poor overall survival. Concerns have also been raised about drug toxicity and long-term detrimental si
Externí odkaz:
https://doaj.org/article/729e1cfcb6b74d95b65479313fda326d
Autor:
Erin R. Bonner, Robin Harrington, Augustine Eze, Miriam Bornhorst, Cassie N. Kline, Heather Gordish-Dressman, Adam Dawood, Biswajit Das, Li Chen, Rini Pauly, P. Mickey Williams, Chris Karlovich, Amanda Peach, D’andra Howell, James Doroshow, Lindsay Kilburn, Roger J. Packer, Sabine Mueller, Javad Nazarian
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-6 (2022)
Abstract Molecular profiling of childhood CNS tumors is critical for diagnosis and clinical management, yet tissue access is restricted due to the sensitive tumor location. We developed a targeted deep sequencing platform to detect tumor driver mutat
Externí odkaz:
https://doaj.org/article/9e314be8330c4153b226c12c059956f7
Autor:
Jonathan M. Payne, Stephen J. C. Hearps, Karin S. Walsh, Iris Paltin, Belinda Barton, Nicole J. Ullrich, Kristina M. Haebich, David Coghill, Gerard A. Gioia, Alan Cantor, Gary Cutter, James H. Tonsgard, David Viskochil, Celiane Rey‐Casserly, Elizabeth K. Schorry, Joseph D. Ackerson, Laura Klesse, Michael J. Fisher, David H. Gutmann, Tena Rosser, Roger J. Packer, Bruce Korf, Maria T. Acosta, Kathryn N. North, the NF Clinical Trials Consortium
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 12, Pp 2555-2565 (2019)
Abstract Objective Rapid developments in understanding the molecular mechanisms underlying cognitive deficits in neurodevelopmental disorders have increased expectations for targeted, mechanism‐based treatments. However, translation from preclinica
Externí odkaz:
https://doaj.org/article/213a2426d5c645e994f7b2496477dbb2
Autor:
Sulgi Lee, Madhuri Kambhampati, M. Isabel Almira-Suarez, Cheng-Ying Ho, Eshini Panditharatna, Seth I. Berger, Joyce Turner, David Van Mater, Lindsay Kilburn, Roger J. Packer, John S. Myseros, Eric Vilain, Javad Nazarian, Miriam Bornhorst
Publikováno v:
Frontiers in Oncology, Vol 9 (2020)
Anaplastic astrocytomas are aggressive glial cancers that present poor prognosis and high recurrence. Heterozygous IDH1 R132H mutations are common in adolescent and young adult anaplastic astrocytomas. In a majority of cases, the IDH1 R132H mutation
Externí odkaz:
https://doaj.org/article/d2bac8e5f1d44d029b2c7bb1a8cc5b82
Autor:
Ben Shofty, Eyal Bergmann, Gil Zur, Jad Asleh, Noam Bosak, Alexandra Kavushansky, F. Xavier Castellanos, Liat Ben-Sira, Roger J. Packer, Gilbert L. Vezina, Shlomi Constantini, Maria T. Acosta, Itamar Kahn
Publikováno v:
Neurobiology of Disease, Vol 130, Iss , Pp 104479- (2019)
Children with the autosomal dominant single gene disorder, neurofibromatosis type 1 (NF1), display multiple structural and functional changes in the central nervous system, resulting in neuropsychological cognitive abnormalities. Here we assessed the
Externí odkaz:
https://doaj.org/article/19bf52b8ac32444e8e7d2519207e66a8
Autor:
Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Diffuse Intrinsic Pontine Gliomas are diagnosed by sampling a small portion of the tumour. Here, using multiple samples from tumours, the authors analyse the spatial and temporal distribution of driver mutations revealing that H3K27M mutations arise
Externí odkaz:
https://doaj.org/article/ca732472c78c4cee9e8f045e01b29088
Publikováno v:
Translational Oncology, Vol 9, Iss 1, Pp 57-63 (2016)
Neuron glia antigen-2 ((NG2), also known as chondroitin sulphate proteoglycan 4, or melanoma-associated chondroitin sulfate proteoglycan) is a type-1 membrane protein expressed by many central nervous system (CNS) cells during development and differe
Externí odkaz:
https://doaj.org/article/76b3914658234cbfab7c40718bd2740b
Autor:
Bernadine eDonahue, n/a en/a, MaryAnne H. Marymont, Sandra eKessel, Matthew K. Iandoli, Thomas eFitzGerald, Emiko eHolmes, Mehmet eKocak, James M. Boyett, Amar eGajjar, Roger J. Packer
Publikováno v:
Frontiers in Oncology, Vol 2 (2012)
Purpose: Associations of RT deviations and outcomes in medulloblastoma have not been defined well, particularly in the era of reduced-dose CSI and chemotherapy. The aim of this study is to evaluate the quality of RT on CCG/POG 9961 and analyze associ
Externí odkaz:
https://doaj.org/article/2b8e7c474273453c9ffbd45b74f0a53e
Autor:
Hasan R. Syed, Lindsay Kilburn, Adriana Fonseca, Javad Nazarian, Chima Oluigbo, John S. Myseros, Roger J. Packer, Robert F. Keating
Publikováno v:
Journal of Neuro-Oncology. 162:449-451
Autor:
Miriam Bornhorst, Augustine Eze, Surajit Bhattacharya, Ethan Putnam, M Isabel Almira‐Suarez, Christopher Rossi, Madhuri Kambhampati, Miguel Almalvez, Mariam Barseghyan, Nicole Del Risco, David Dotson, Joyce Turner, John S Myseros, Eric Vilain, Roger J Packer, Javad Nazarian, Brian Rood, Hayk Barseghyan
Publikováno v:
The Journal of Pathology.