Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Roger J. Griffin"'
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
DNA double-strand breaks (DSB) are the most cytotoxic lesions induced by topoisomerase II poisons. Nonhomologous end joining (NHEJ) is a major pathway for DSB repair and requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK catalytic subuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c9f0d0e3e98828130b4f41f16e3e80
https://doi.org/10.1158/1535-7163.c.6535653.v1
https://doi.org/10.1158/1535-7163.c.6535653.v1
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
PDF file, 316KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3174dc79b3c750b99d9eff50af83dd73
https://doi.org/10.1158/1535-7163.22497552
https://doi.org/10.1158/1535-7163.22497552
Autor:
Nicola J. Curtin, Graeme C.M. Smith, David R. Newell, Niall M.B. Martin, Pia Thommes, Andrew Slade, Keith Menear, Roger J. Griffin, Liam Cornell, Julia Bardos, Jody Barbeau, Michele Tavecchio, Celine Cano, Caroline J. Richardson, Helen Jenkins, Yan Zhao, Michael A. Batey, Joanne M. Munck
PDF file, 112KB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2593b57508ee0ef2270374929c03d884
https://doi.org/10.1158/1535-7163.22497549
https://doi.org/10.1158/1535-7163.22497549
Autor:
Nicola J. Curtin, Bernard T. Golding, Roger J. Griffin, David R. Newell, Marion Barton, Hannah Barlow, Julian S. Northen, Mei-Ju Lin, Lan-Zhen Wang, Kappusamy Saravanan, Huw D. Thomas
Antifolates have been used to treat cancer for the last 50 years and remain the mainstay of many therapeutic regimes. Nucleoside salvage, which depends on plasma membrane transport, can compromise the activity of antifolates. The cardiovascular drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77920703b9bfbb55eab67ef3d2666043
https://doi.org/10.1158/1535-7163.c.6532236
https://doi.org/10.1158/1535-7163.c.6532236
Autor:
Nicola J. Curtin, Bernard T. Golding, Roger J. Griffin, David R. Newell, Marion Barton, Hannah Barlow, Julian S. Northen, Mei-Ju Lin, Lan-Zhen Wang, Kappusamy Saravanan, Huw D. Thomas
Supplementary Fig. S3 from Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fca8588aa26a79a4189b98acd55ca00
https://doi.org/10.1158/1535-7163.22486086.v1
https://doi.org/10.1158/1535-7163.22486086.v1
Autor:
Barbara W. Durkacz, Caroline A. Austin, Ian G. Cowell, Roger J. Griffin, Celine Cano-Soumillac, Andrew R. Pettitt, Robert Harris, Anthony Carter, Christopher Lowe, Fran O'Neill, Graham H. Jackson, Geoffrey P. Summerfield, Tryfonia Mainou-Fowler, Sarah L. Elliott, Elaine Willmore
Purpose: del(17p), del(11q), and associated p53 dysfunction predict for short survival and chemoresistance in B-cell chronic lymphocytic leukemia (CLL). DNA-dependent protein kinase (DNA-PK) is activated by DNA damage and mediates DNA double-strand b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134f47c2cf25b662688cd8883181d12b
https://doi.org/10.1158/1078-0432.c.6517021.v1
https://doi.org/10.1158/1078-0432.c.6517021.v1
Autor:
Barbara W. Durkacz, Caroline A. Austin, Ian G. Cowell, Roger J. Griffin, Celine Cano-Soumillac, Andrew R. Pettitt, Robert Harris, Anthony Carter, Christopher Lowe, Fran O'Neill, Graham H. Jackson, Geoffrey P. Summerfield, Tryfonia Mainou-Fowler, Sarah L. Elliott, Elaine Willmore
Supplementary Data from DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406fd62e571ee5eb98ec0cf9f2b448f4
https://doi.org/10.1158/1078-0432.22439584
https://doi.org/10.1158/1078-0432.22439584
Autor:
Duncan C. Miller, Tristan Reuillon, Lauren Molyneux, Timothy Blackburn, Simon J. Cook, Noel Edwards, Jane A. Endicott, Bernard T. Golding, Roger J. Griffin, Ian Hardcastle, Suzannah J. Harnor, Amy Heptinstall, Pamela Lochhead, Mathew P. Martin, Nick C. Martin, Stephanie Myers, David R. Newell, Richard A. Noble, Nicole Phillips, Laurent Rigoreau, Huw Thomas, Julie A. Tucker, Lan-Zhen Wang, Michael J. Waring, Ai-Ching Wong, Stephen R. Wedge, Martin E. M. Noble, Celine Cano
Publikováno v:
Journal of Medicinal Chemistry. 65:6513-6540
The nonclassical extracellular signal-related kinase 5 (ERK5) mitogen-activated protein kinase pathway has been implicated in increased cellular proliferation, migration, survival, and angiogenesis; hence, ERK5 inhibition may be an attractive approac
Autor:
Benoit Carbain, Keisha Hearn, Ildiko Maria Buck, Burcu Anil, Sarah J. Cully, Gianni Chessari, Jane A. Endicott, John Lunec, Neil T. Thompson, Juan Castro, Roger J. Griffin, Rhian S. Holvey, Karen Haggerty, Charlotte H. Revill, Ruth H. Bawn, Stephen R. Wedge, Christiane Riedinger, Christopher N. Johnson, Bernard T. Golding, Lynsey Fazal, Ian R. Hardcastle, Mladen Vinkovic, Claire E. Jennings, Jong Sook Ahn, Bian Zhang, Pamela A. Williams, Celine Cano, Suzannah J. Harnor, Ben Cons, Stephen J. Hobson, E. Anscombe, Jeffrey D. St. Denis, Steven Howard, David R. Newell, Emiliano Tamanini, Nicola E. Wilsher, Miller Duncan Charles, Huw D. Thomas, Timothy J. Blackburn, Martin E.M. Noble, Judith Reeks, Yan Zhao, Luke Bevan
Publikováno v:
Journal of Medicinal Chemistry. 64:4071-4088
Inhibition of murine double minute 2 (MDM2)-p53 protein-protein interaction with small molecules has been shown to reactivate p53 and inhibit tumor growth. Here, we describe rational, structure-guided, design of novel isoindolinone-based MDM2 inhibit
Autor:
Kathy Boxall, Mangaleswaran Sivaprakasam, David P. Turner, Roger J. Griffin, Corine Mas-Droux, Benoit Carbain, Bernard T. Golding, Richard Bayliss, Ian R. Hardcastle, Mark W. Richards, Andrew M. Fry, Christopher R. Coxon, David R. Newell, Celine Cano, Suzannah J. Harnor, Christopher J. Matheson
Publikováno v:
RSC Medicinal Chemistry
Renewed interest in covalent inhibitors of enzymes implicated in disease states has afforded several agents targeted at protein kinases of relevance to cancers.
Renewed interest in covalent inhibitors of enzymes implicated in disease states has
Renewed interest in covalent inhibitors of enzymes implicated in disease states has