Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Roger J. Brideau"'
Autor:
John D. Knafels, Chris Limberakis, Paul J. Pagano, Murphy Sean T, Joseph S. Warmus, Sandra Lightle, Daniel F. Ortwine, Joel C. Bronstein, Terry Podoll, Clarke Taylor, Igor Mochalkin, Johnson Timothy Allan, Cheryl L. Quinn, Roger J. Brideau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:2536-2543
Lipid A is an essential component of the Gram negative outer membrane, which protects the bacterium from attack of many antibiotics. The Lipid A biosynthesis pathway is essential for Gram negative bacterial growth and is unique to these bacteria. The
Autor:
Mark C. Sulavik, Ji-Young Kim, Rose Kelly, Allison Laura Choy, Roger J. Brideau, Poel Toni-Jo, Joanne Brodfuehrer, Gary E. Zurenko, Tong Zhu, Michael Dority, Cai Hongliang, Barbachyn Michael R, Joan K. Brieland, Thomas Richard C, Frederick E. Boyer, Michael R. Dermyer, Martin Joseph P, Michael D. Huband, Alan P. Brown, Daniel E. Ross, Debra Hanna, Laura A. Skerlos, Robert C. Gadwood, Wade J. Adams, Paul J. Pagano, Aristoff Paul A, Christopher Huber, J.V.N. Vara Prasad, Charles W. Ford
Publikováno v:
Journal of Medicinal Chemistry. 50:5886-5889
Oxazolidinones possessing a C-5 carboxamide functionality (reverse amides) represent a new series of compounds that block bacterial protein synthesis. These reverse amides also exhibited less potency against monoamine oxidase (MAO) enzymes and thus p
Autor:
Mary L. Knechtel, Michael W. Wathen, Fred L. Homa, Janet L. Wieber, Michele M. Cudahy, Thomas W. Pitts, Roger A. Poorman, Nancee L. Oien, Mark E. Schnute, Todd A. Hopkins, Roger J. Brideau
Publikováno v:
Journal of Medicinal Chemistry. 48:5794-5804
A novel series of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potential antivirals against human herpesvirus infections resulting from human cytomegalovirus (HCMV), herpes simplex virus type 1 (HSV-1), and varicella-
Autor:
Nancee L. Oien, Janet L. Wieber, Vaillancourt Valerie A, Ellen E. Vera, Michael W. Wathen, Todd A. Hopkins, Mary L. Knechtel, Karen F. Wilkinson, Bob D. Rush, Roger J. Brideau, Francis J. Schwende, Audris Huang
Publikováno v:
Antiviral Research. 54:19-28
We identified a novel class of 4-oxo-dihydroquinolines represented by PNU-183792 which specifically inhibit herpesvirus polymerases. PNU-183792 was highly active against human cytomegalovirus (HCMV, IC(50) value 0.69 microM), varicella zoster virus (
Autor:
John A. Tucker, Roger A. Poorman, Nancee L. Oien, Roger J. Brideau, Todd A. Hopkins, John A. Shelly, Janet L. Wieber, Michael W. Wathen, Mary L. Knechtel, Audris Huang, Robert A. Anstadt, Peter A. Wells, Vallerie A. Vaillancourt, Terrance L. Clayton
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:724-730
Through broad screening of the compound library at Pharmacia, a naphthalene carboxamide was identified as a nonnucleoside inhibitor of human cytomegalovirus (HCMV) polymerase. Structure-activity relationship studies demonstrated that a quinoline ring
Autor:
Stephen Buxser, Colin J. Dunn, Douglas Decker, Steven M. Vroegop, Louise A. Galinet, Darryl L. Chapman, Kathleen A. Ready, Roger J. Brideau
Publikováno v:
International Journal of Immunopharmacology. 21:391-409
In murine severe experimental autoimmune encephalomyelitis (EAE), an animal model for the human disease multiple sclerosis (MS), we tested the efficacy of a 5-halo-6-phenyl pyrimidinone compound, bropirimine (PNU-54461). We observed that the compound
Autor:
Roger J Brideau
Publikováno v:
Expert Opinion on Investigational Drugs. 6:1753-1756
The 10th Annual International Conference on Antiviral Research held in Atlanta, GA was attended by nearly 500 participants representing 23 countries. The next meeting will be held in San Diego, CA in April 1998. The web site for additional informatio
Publikováno v:
Vaccine. 12:731-735
Local IgA and IgG antibodies against respiratory syncytial virus (RSV) were induced in the respiratory tract of mice following intranasal vaccination with an RSV chimeric FG glycoprotein and cholera toxin B (CTB) as a mucosal adjuvant. Local antibody
Publikováno v:
Journal of Medical Virology. 68:234-236
The susceptibility of human cytomegalovirus (CMV) and varicella zoster virus (VZV) clinical isolates to PNU-183792, a 4-oxo-dihydroquinoline, was examined. The antiviral potency of PNU-183792, a non-nucleoside inhibitor, was compared to the licensed
Autor:
Robert A. Olmsted, Michael W. Wathen, Fred L. Homa, Roger J. Brideau, Darrell R. Thomsen, Donna J. Lehman
Publikováno v:
Journal of General Virology. 74:1995-1999
A cotton rat model of experimental human respiratory syncytial virus (RSV) and human parainfluenza virus type 3 (PIV-3) infection was used to examine the efficacy of FRHNP, a novel chimeric glycoprotein which contains the extracellular regions of the