Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Roger J W, Truscott"'
Publikováno v:
Nutrients, Vol 14, Iss 12, p 2495 (2022)
(1) Background: Changes in phospholipid (phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine, i.e., PC, PE and PS) composition with age in the mitochondrial and microsomal membranes of the human cerebellum and motor cortex were exami
Externí odkaz:
https://doaj.org/article/05ef5eb257c64936b142cf852607ed29
Autor:
Michael G. Friedrich, Amanda Skora, Sarah E. Hancock, Todd W. Mitchell, Paul L. Else, Roger J. W. Truscott
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3521 (2021)
The truncation of Tau is thought to be important in promoting aggregation, with this feature characterising the pathology of dementias such as Alzheimer disease. Antibodies to the C-terminal and N-terminal regions of Tau were employed to examine Tau
Externí odkaz:
https://doaj.org/article/afdd761f19554590a1f46cf13b234256
Autor:
Roger J. W. Truscott
This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain mo
Autor:
Richard M. Lambrecht, Keiryn L. Bennett, Margaret M. Sheil, and Roger J. W. Truscott, Suzanne V. Smith
Publikováno v:
Bioconjugate Chemistry. 7:16-22
Electrospray mass spectrometry (ESI-MS) has been used to examine monoclonal antibodies (MAbs), antibody fragments (Fab and Fc), modified fragments, and a range of other chemically-modified proteins as part of a study aimed at establishing ESI-MS as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4d178940e3e83df37544371c7d440c
https://doi.org/10.1021/bc950064c
https://doi.org/10.1021/bc950064c
Publikováno v:
The Journal of biological chemistry. 287(46)
Long-lived proteins exist in a number of tissues in the human body; however, little is known about the reactions involved in their degradation over time. Lens proteins, which do not turn over, provide a useful system to examine such processes. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce91600c8de2c6bc178e8bbc4e25e2c0
https://pubmed.ncbi.nlm.nih.gov/22995907
https://pubmed.ncbi.nlm.nih.gov/22995907
Autor:
Shih-Ping, Su, Brian, Lyons, Michael, Friedrich, Jason D, McArthur, Xiaomin, Song, Dylan, Xavier, Roger J W, Truscott, John A, Aquilina
Publikováno v:
Aging cell. 11(6)
The centre of the human lens, which is composed of proteins that were synthesized prior to birth, is an ideal model for the evaluation of long-term protein stability and processes responsible for the degradation of macromolecules. By analysing the se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9f879c51bdccb64e31b8c8a8256f948
https://pubmed.ncbi.nlm.nih.gov/22805275
https://pubmed.ncbi.nlm.nih.gov/22805275
Publikováno v:
Aging cell. 6(6)
Presbyopia, the inability to focus up close, affects everyone by age 50 and is the most common eye condition. It is thought to result from changes to the lens over time making it less flexible. We present evidence that presbyopia may be the result of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ad12072c08fdb4bb386ba9a741206b9
https://pubmed.ncbi.nlm.nih.gov/17973972
https://pubmed.ncbi.nlm.nih.gov/17973972
Publikováno v:
Biochemistry. 45(6)
The alpha-, beta-, and gamma-crystallins are the major structural proteins of mammalian lenses. The human lens also contains tryptophan-derived UV filters, which are known to spontaneously deaminate at physiological pH and covalently attach to lens p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a36a4c5358c04e6f693bc4365c78b856
https://pubmed.ncbi.nlm.nih.gov/16460031
https://pubmed.ncbi.nlm.nih.gov/16460031
Publikováno v:
Advances in experimental medicine and biology. 527
Tryptophan-derived UV filters (kynurenine and 3-hydroxylkynurenine glucoside) have recently been shown to bind to human lens proteins. These UV filter adducts increase in amount with age and appear to be mainly responsible for the yellowing of the le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4af7134b3503d1ce762bc38e475a147e
https://pubmed.ncbi.nlm.nih.gov/15206741
https://pubmed.ncbi.nlm.nih.gov/15206741
Autor:
Andrew C, Terentis, Shane R, Thomas, Osamu, Takikawa, Tamantha K, Littlejohn, Roger J W, Truscott, Robert S, Armstrong, Syun-Ru, Yeh, Roland, Stocker
Publikováno v:
The Journal of biological chemistry. 277(18)
Indoleamine 2,3-dioxygenase is a heme enzyme that catalyzes the oxidative degradation of L-Trp and other indoleamines. We have used resonance Raman spectroscopy to characterize the heme environment of purified recombinant human indoleamine 2,3-dioxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3c3079c4e077b96d5452e1003de3fcd
https://pubmed.ncbi.nlm.nih.gov/11867636
https://pubmed.ncbi.nlm.nih.gov/11867636