Zobrazeno 1 - 10
of 420
pro vyhledávání: '"Roger J Summers"'
Autor:
Jean-Francois Gautier, Nicolas Venteclef, Assam El-Osta, Andrew J Murphy, Darren M Riddy, Helene L Kammoun, Sanja Bosnyak-Gladovic, Rocio De la Fuente Gonzalez, Jon Merlin, Mark Ziemann, Stewart Fabb, Tracie L Pierce, Natalie Diepenhorst, Patricia Rueda, William N Charman, Arthur Christopoulos, Patrick M Sexton, Roger J Summers, Mark A Febbraio, Philippe Delerive, Christopher J Langmead
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/4720f931b7654da0bb23e3c27d888fd0
Autor:
Darren M Riddy, Emily Goy, Philippe Delerive, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197177 (2018)
Monocyte-like cell lines (MCLCs), including THP-1, HL-60 and U-937 cells, are used routinely as surrogates for isolated human peripheral blood mononuclear cells (PBMCs). To systematically evaluate these immortalised cells and PBMCs as model systems t
Externí odkaz:
https://doaj.org/article/06eea1bb862d4727bf7f9a4135f38567
Autor:
Patricia Rueda, Elizabeth Harley, Yao Lu, Gregory D Stewart, Stewart Fabb, Natalie Diepenhorst, Béatrice Cremers, Marie-Hélène Rouillon, Isabelle Wehrle, Anne Geant, Gwladys Lamarche, Katie Leach, William N Charman, Arthur Christopoulos, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146846 (2016)
Phenotyping of Gprc6a KO mice has shown that this promiscuous class C G protein coupled receptor is variously involved in regulation of metabolism, inflammation and endocrine function. Such effects are described as mediated by extracellular calcium,
Externí odkaz:
https://doaj.org/article/b658292f3cbd438ca68f91442b0499b5
Autor:
Emanuela Talamonti, Jelena Davegardh, Anastasia Kalinovich, Sten M.M. van Beek, Nodi Dehvari, Carina Halleskog, Hamza M. Bokhari, Dana S. Hutchinson, Seungmin Ham, Laura J. Humphrys, Nicola C. Dijon, Aikaterini Motso, Anna Sandstrom, Evelyn Zacharewicz, Ilga Mutule, Edgars Suna, Jana Spura, Karolina Ditrychova, Leigh A. Stoddart, Nicholas D. Holliday, Shane C. Wright, Volker M. Lauschke, Soren Nielsen, Camilla Scheele, Elizabeth Cheesman, Joris Hoeks, Peter Molenaar, Roger J. Summers, Benjamin Pelcman, Gopala K. Yakala, Tore Bengtsson
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101931- (2024)
Objective: Simultaneous activation of β2- and β3-adrenoceptors (ARs) improves whole-body metabolism via beneficial effects in skeletal muscle and brown adipose tissue (BAT). Nevertheless, high-efficacy agonists simultaneously targeting these recept
Externí odkaz:
https://doaj.org/article/3d4a3a5490234ea7a397025d54414624
Autor:
Arhamatoulaye Maïga, Jon Merlin, Elodie Marcon, Céline Rouget, Maud Larregola, Bernard Gilquin, Carole Fruchart-Gaillard, Evelyne Lajeunesse, Charles Marchetti, Alain Lorphelin, Laurent Bellanger, Roger J Summers, Dana S Hutchinson, Bronwyn A Evans, Denis Servent, Nicolas Gilles
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68841 (2013)
ρ-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the α1A-adrenoceptor. This toxin has atypical pharmacological properties, including incomplete inhibition of (3)H-prazosin or (125)I-HEAT binding and insurmount
Externí odkaz:
https://doaj.org/article/ea1b5de2a53b4c798bdec40a54b07f16
Autor:
Seungmin Ham, Saori Mukaida, Masaaki Sato, Peter Keov, Tore Bengtsson, Sebastian Furness, Nicholas D. Holliday, Bronwyn A. Evans, Roger J. Summers, Dana S. Hutchinson
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract Truncation of the C‐terminal tail of the β2‐AR, transfection of βARKct or over‐expression of a kinase‐dead GRK mutant reduces isoprenaline‐stimulated glucose uptake, indicating that GRK is important for this response. We explored
Externí odkaz:
https://doaj.org/article/8b05f72e8cfe40dba5549ad1377f554f
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/90f0215f02cc403bb4eb8738d20fc4bf
Autor:
Patricia Rueda, Jon Merlin, Stefano Chimenti, Michel Feletou, Jerome Paysant, Paul J. White, Arthur Christopoulos, Patrick M. Sexton, Roger J. Summers, William N. Charman, Lauren T. May, Christopher J. Langmead
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Adenosine A1 receptors (A1R) are a potential target for cardiac injury treatment due to their cardioprotective/antihypertrophic actions, but drug development has been hampered by on-target side effects such as bradycardia and altered renal hemodynami
Externí odkaz:
https://doaj.org/article/76be888ff9584388bd20cd56e08b4643
Autor:
Jon Merlin, Julia Park, Teresa H. Vandekolk, Stewart A. Fabb, Jeanne Allinne, Roger J. Summers, Christopher J. Langmead, Darren M. Riddy
Publikováno v:
Molecular Pharmacology. 101:246-256
Specialized proresolving mediators (SPMs) and their cognate G protein-coupled receptors are implicated in autoimmune disorders, including chronic inflammation, rheumatoid arthritis, systemic scleroderma, and lupus erythematosus. To date, six G protei
Autor:
Nigel J. M. Birdsall, Stephen J Lolait, Hans-Jürgen Wester, Paul L. Chazot, Sadashiva S. Karnik, Simon D. Harding, Celine Valant, Stephen P.H. Alexander, Olivier Civelli, Zsolt Csaba, Mastgugu Horiuchi, Khuraijam Dhanachandra Singh, Theodore L. Goodfriend, Morley D. Hollenberg, Duuamene Nyimanu, Shlomo Melmed, G. Enrico Rovati, Xavier Norel, Leigh A. Stoddart, Klemens Kaupmann, Robyn Macrae, Nicholas D. Holliday, Deborah L. Segaloff, Justo P. Castaño, Tony Ngo, Gordon Dent, Jean-Martin Beaulieu, Thomas L Williams, Antonia Cianciulli, Paweł Kozielewicz, Xaria X. Li, Jyrki P. Kukkonen, Craig A. McArdle, John D. Lee, Philippe Rondard, Steven D. Douglas, Hubert Vaudry, Khaled A. Al-Hosaini, Nan Chiang, Bernhard Bettler, Giovanni Tulipano, Corinne Bousquet, Karen J. Gregory, Craig Gerard, Robert T. Jensen, Stefan Schulz, Rithwik Ramachandran, Ross A. D. Bathgate, Deepa Jonnalagadda, David M. Thal, Takio Kitazawa, Manisha Ray, Bice Chini, Thomas Unger, Marta Fumagalli, Jean-Pierre Vilardaga, Donald T. Ward, Roger G. Pertwee, Stefan Offermanns, Marvin C. Gershengorn, Marc Parmentier, Pieter Timmermans, Eamonn Kelly, Yukihiko Sugimoto, Hamiyet Unal, Vincenzo Mitolo, Alistair Mathie, Emma L. Veale, Andrew L. Gundlach, Anthony P. Davenport, Mark T. Quinn, Jérôme Leprince, Christa E. Müller, Geoffrey Burnstock, Akos Heinemann, Jacqueline R. Kemp, Richard D. Ye, Bernard Mouillac, Roger J. Summers, Raul R. Gainetdinov, Girolamo Calò, Philip N. Murphy, Amelie Lupp, Kalyan C. Tirupula, Walter G. Thomas, Julien Hanson, Ahsan Husain, Katie Leach, Lucie H. Clapp, Hans Bräuner-Osborne, Gunnar Schulte, Kenneth E. Bernstein, Jean Mazella, Torsten Schöneberg, Satoru Eguchi, Martin C. Michel, Maria Antonietta Panaro, Kevin J. Catt, Rainer K. Reinscheid, Hans-Jürgen Kreienkamp, Wayne R. Alexander, Emanuel Escher, Anne Marie O'Carroll, Magnus Bäck, Laurence J. Miller, Jane F. Armstrong, Chiara Ruzza, Trent M. Woodruff, Daniel Hoyer, Chengcan Yao, Maria P. Abbracchio, John A. Peters, Gary B. Willars, Jean-Philippe Pin, David Vaudry, Debbie L. Hay, François Boulay, Davide Lecca, Eric R. Prossnitz, Arthur Christopoulos, Victoria A. Blaho, Yasuyuki Kihara, Charles Kennedy, Christopher Southan, László Hunyady, Pascal Dournaud, Fernand Gobeil, Cyril Goudet, Charles N. Serhan, Claes Dahlgren, Jörg Hamann, Tobias Langenhan, Ralf Jockers, Nicholas M. Barnes, Jean-Louis Nahon, Richard L. Hauger, Adam J. Pawson, Gareth J. Sanger, Tung Fong, Susan E. Leeman, Elena Faccenda, Edward J. Filardo, Valerie P. Tan, Marc de Gasparo, Ji Ming Wang, Jamie A. Davies, Jerold Chun, Stefania Ceruti, Tadashi Inagami, Réjean Couture, Kenneth A. Jacobson, Patrick Vanderheyden, Adriaan P. IJzerman, Janet J. Maguire, Christopher S. Walker
Publikováno v:
British Journal of Pharmacology, 178, S27-S156. Wiley
Alexander, S P, Christopoulos, A, Davenport, A P, Kelly, E, Mathie, A, Peters, J A, Veale, E L, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Abbracchio, M P, Alexander, W, Al-Hosaini, K, Bäck, M, Barnes, N M, Bathgate, R, Beaulieu, J-M, Bernstein, K E, Bettler, B, Birdsall, N J M, Blaho, V, Boulay, F, Bousquet, C, Bräuner-Osborne, H, Burnstock, G, Caló, G, Castaño, J P, Catt, K J, Ceruti, S, Chazot, P, Chiang, N, Chini, B, Chun, J, Cianciulli, A, Civelli, O, Clapp, L H, Couture, R, Csaba, Z, Dahlgren, C, Dent, G, Singh, K D, Douglas, S D, Dournaud, P, Eguchi, S, Escher, E, Filardo, E J, Fong, T, Fumagalli, M, Gainetdinov, R R, Gasparo, M D, Gerard, C, Gershengorn, M, Gobeil, F, Goodfriend, T L, Goudet, C, Gregory, K J, Gundlach, A L, Hamann, J, Hanson, J, Hauger, R L, Hay, D L, Heinemann, A, Hollenberg, M D, Holliday, N D, Horiuchi, M, Hoyer, D, Hunyady, L, Husain, A, IJzerman, A P, Inagami, T, Jacobson, K A, Jensen, R T, Jockers, R, Jonnalagadda, D, Karnik, S, Kaupmann, K, Kemp, J, Kennedy, C, Kihara, Y, Kitazawa, T, Kozielewicz, P, Kreienkamp, H-J, Kukkonen, J P, Langenhan, T, Leach, K, Lecca, D, Lee, J D, Leeman, S E, Leprince, J, Li, X X, Williams, T L, Lolait, S J, Lupp, A, Macrae, R, Maguire, J, Mazella, J, McArdle, C A, Melmed, S, Michel, M C, Miller, L J, Mitolo, V, Mouillac, B, Müller, C E, Murphy, P, Nahon, J-L, Ngo, T, Norel, X, Nyimanu, D, O'Carroll, A-M, Offermanns, S, Panaro, M A, Parmentier, M, Pertwee, R G, Pin, J-P, Prossnitz, E R, Quinn, M, Ramachandran, R, Ray, M, Reinscheid, R K, Rondard, P, Rovati, G E, Ruzza, C, Sanger, G J, Schöneberg, T, Schulte, G, Schulz, S, Segaloff, D L, Serhan, C N, Stoddart, L A, Sugimoto, Y, Summers, R, Tan, V P, Thal, D, Thomas, W W, Timmermans, P B M W M, Tirupula, K, Tulipano, G, Unal, H, Unger, T, Valant, C, Vanderheyden, P, Vaudry, D, Vaudry, H, Vilardaga, J-P, Walker, C S, Wang, J M, Ward, D T, Wester, H-J, Willars, G B, Woodruff, T M, Yao, C & Ye, R D 2021, ' THE CONCISE GUIDE TO PHARMACOLOGY 2021/22 : G protein-coupled receptors ', British Journal of Pharmacology, vol. 178 Suppl 1, no. S1, pp. S27-S156 . https://doi.org/10.1111/bph.15538
British journal of pharmacology, 178(S1), S27-S156. Wiley-Blackwell
Alexander, S P, Christopoulos, A, Davenport, A P, Kelly, E, Mathie, A, Peters, J A, Veale, E L, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Abbracchio, M P, Alexander, W, Al-Hosaini, K, Bäck, M, Barnes, N M, Bathgate, R, Beaulieu, J-M, Bernstein, K E, Bettler, B, Birdsall, N J M, Blaho, V, Boulay, F, Bousquet, C, Bräuner-Osborne, H, Burnstock, G, Caló, G, Castaño, J P, Catt, K J, Ceruti, S, Chazot, P, Chiang, N, Chini, B, Chun, J, Cianciulli, A, Civelli, O, Clapp, L H, Couture, R, Csaba, Z, Dahlgren, C, Dent, G, Singh, K D, Douglas, S D, Dournaud, P, Eguchi, S, Escher, E, Filardo, E J, Fong, T, Fumagalli, M, Gainetdinov, R R, Gasparo, M D, Gerard, C, Gershengorn, M, Gobeil, F, Goodfriend, T L, Goudet, C, Gregory, K J, Gundlach, A L, Hamann, J, Hanson, J, Hauger, R L, Hay, D L, Heinemann, A, Hollenberg, M D, Holliday, N D, Horiuchi, M, Hoyer, D, Hunyady, L, Husain, A, IJzerman, A P, Inagami, T, Jacobson, K A, Jensen, R T, Jockers, R, Jonnalagadda, D, Karnik, S, Kaupmann, K, Kemp, J, Kennedy, C, Kihara, Y, Kitazawa, T, Kozielewicz, P, Kreienkamp, H-J, Kukkonen, J P, Langenhan, T, Leach, K, Lecca, D, Lee, J D, Leeman, S E, Leprince, J, Li, X X, Williams, T L, Lolait, S J, Lupp, A, Macrae, R, Maguire, J, Mazella, J, McArdle, C A, Melmed, S, Michel, M C, Miller, L J, Mitolo, V, Mouillac, B, Müller, C E, Murphy, P, Nahon, J-L, Ngo, T, Norel, X, Nyimanu, D, O'Carroll, A-M, Offermanns, S, Panaro, M A, Parmentier, M, Pertwee, R G, Pin, J-P, Prossnitz, E R, Quinn, M, Ramachandran, R, Ray, M, Reinscheid, R K, Rondard, P, Rovati, G E, Ruzza, C, Sanger, G J, Schöneberg, T, Schulte, G, Schulz, S, Segaloff, D L, Serhan, C N, Stoddart, L A, Sugimoto, Y, Summers, R, Tan, V P, Thal, D, Thomas, W W, Timmermans, P B M W M, Tirupula, K, Tulipano, G, Unal, H, Unger, T, Valant, C, Vanderheyden, P, Vaudry, D, Vaudry, H, Vilardaga, J-P, Walker, C S, Wang, J M, Ward, D T, Wester, H-J, Willars, G B, Woodruff, T M, Yao, C & Ye, R D 2021, ' THE CONCISE GUIDE TO PHARMACOLOGY 2021/22 : G protein-coupled receptors ', British Journal of Pharmacology, vol. 178, no. S1, pp. S27-S156 . https://doi.org/10.1111/bph.15538
Alexander, S P, Christopoulos, A, Davenport, A P, Kelly, E, Mathie, A, Peters, J A, Veale, E L, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Abbracchio, M P, Alexander, W, Al-Hosaini, K, Bäck, M, Barnes, N M, Bathgate, R, Beaulieu, J-M, Bernstein, K E, Bettler, B, Birdsall, N J M, Blaho, V, Boulay, F, Bousquet, C, Bräuner-Osborne, H, Burnstock, G, Caló, G, Castaño, J P, Catt, K J, Ceruti, S, Chazot, P, Chiang, N, Chini, B, Chun, J, Cianciulli, A, Civelli, O, Clapp, L H, Couture, R, Csaba, Z, Dahlgren, C, Dent, G, Singh, K D, Douglas, S D, Dournaud, P, Eguchi, S, Escher, E, Filardo, E J, Fong, T, Fumagalli, M, Gainetdinov, R R, Gasparo, M D, Gerard, C, Gershengorn, M, Gobeil, F, Goodfriend, T L, Goudet, C, Gregory, K J, Gundlach, A L, Hamann, J, Hanson, J, Hauger, R L, Hay, D L, Heinemann, A, Hollenberg, M D, Holliday, N D, Horiuchi, M, Hoyer, D, Hunyady, L, Husain, A, IJzerman, A P, Inagami, T, Jacobson, K A, Jensen, R T, Jockers, R, Jonnalagadda, D, Karnik, S, Kaupmann, K, Kemp, J, Kennedy, C, Kihara, Y, Kitazawa, T, Kozielewicz, P, Kreienkamp, H-J, Kukkonen, J P, Langenhan, T, Leach, K, Lecca, D, Lee, J D, Leeman, S E, Leprince, J, Li, X X, Williams, T L, Lolait, S J, Lupp, A, Macrae, R, Maguire, J, Mazella, J, McArdle, C A, Melmed, S, Michel, M C, Miller, L J, Mitolo, V, Mouillac, B, Müller, C E, Murphy, P, Nahon, J-L, Ngo, T, Norel, X, Nyimanu, D, O'Carroll, A-M, Offermanns, S, Panaro, M A, Parmentier, M, Pertwee, R G, Pin, J-P, Prossnitz, E R, Quinn, M, Ramachandran, R, Ray, M, Reinscheid, R K, Rondard, P, Rovati, G E, Ruzza, C, Sanger, G J, Schöneberg, T, Schulte, G, Schulz, S, Segaloff, D L, Serhan, C N, Stoddart, L A, Sugimoto, Y, Summers, R, Tan, V P, Thal, D, Thomas, W W, Timmermans, P B M W M, Tirupula, K, Tulipano, G, Unal, H, Unger, T, Valant, C, Vanderheyden, P, Vaudry, D, Vaudry, H, Vilardaga, J-P, Walker, C S, Wang, J M, Ward, D T, Wester, H-J, Willars, G B, Woodruff, T M, Yao, C & Ye, R D 2021, ' THE CONCISE GUIDE TO PHARMACOLOGY 2021/22 : G protein-coupled receptors ', British Journal of Pharmacology, vol. 178 Suppl 1, no. S1, pp. S27-S156 . https://doi.org/10.1111/bph.15538
British journal of pharmacology, 178(S1), S27-S156. Wiley-Blackwell
Alexander, S P, Christopoulos, A, Davenport, A P, Kelly, E, Mathie, A, Peters, J A, Veale, E L, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Abbracchio, M P, Alexander, W, Al-Hosaini, K, Bäck, M, Barnes, N M, Bathgate, R, Beaulieu, J-M, Bernstein, K E, Bettler, B, Birdsall, N J M, Blaho, V, Boulay, F, Bousquet, C, Bräuner-Osborne, H, Burnstock, G, Caló, G, Castaño, J P, Catt, K J, Ceruti, S, Chazot, P, Chiang, N, Chini, B, Chun, J, Cianciulli, A, Civelli, O, Clapp, L H, Couture, R, Csaba, Z, Dahlgren, C, Dent, G, Singh, K D, Douglas, S D, Dournaud, P, Eguchi, S, Escher, E, Filardo, E J, Fong, T, Fumagalli, M, Gainetdinov, R R, Gasparo, M D, Gerard, C, Gershengorn, M, Gobeil, F, Goodfriend, T L, Goudet, C, Gregory, K J, Gundlach, A L, Hamann, J, Hanson, J, Hauger, R L, Hay, D L, Heinemann, A, Hollenberg, M D, Holliday, N D, Horiuchi, M, Hoyer, D, Hunyady, L, Husain, A, IJzerman, A P, Inagami, T, Jacobson, K A, Jensen, R T, Jockers, R, Jonnalagadda, D, Karnik, S, Kaupmann, K, Kemp, J, Kennedy, C, Kihara, Y, Kitazawa, T, Kozielewicz, P, Kreienkamp, H-J, Kukkonen, J P, Langenhan, T, Leach, K, Lecca, D, Lee, J D, Leeman, S E, Leprince, J, Li, X X, Williams, T L, Lolait, S J, Lupp, A, Macrae, R, Maguire, J, Mazella, J, McArdle, C A, Melmed, S, Michel, M C, Miller, L J, Mitolo, V, Mouillac, B, Müller, C E, Murphy, P, Nahon, J-L, Ngo, T, Norel, X, Nyimanu, D, O'Carroll, A-M, Offermanns, S, Panaro, M A, Parmentier, M, Pertwee, R G, Pin, J-P, Prossnitz, E R, Quinn, M, Ramachandran, R, Ray, M, Reinscheid, R K, Rondard, P, Rovati, G E, Ruzza, C, Sanger, G J, Schöneberg, T, Schulte, G, Schulz, S, Segaloff, D L, Serhan, C N, Stoddart, L A, Sugimoto, Y, Summers, R, Tan, V P, Thal, D, Thomas, W W, Timmermans, P B M W M, Tirupula, K, Tulipano, G, Unal, H, Unger, T, Valant, C, Vanderheyden, P, Vaudry, D, Vaudry, H, Vilardaga, J-P, Walker, C S, Wang, J M, Ward, D T, Wester, H-J, Willars, G B, Woodruff, T M, Yao, C & Ye, R D 2021, ' THE CONCISE GUIDE TO PHARMACOLOGY 2021/22 : G protein-coupled receptors ', British Journal of Pharmacology, vol. 178, no. S1, pp. S27-S156 . https://doi.org/10.1111/bph.15538
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef5f3d1320e3d9fb87604fe0e7987c5
https://cris.maastrichtuniversity.nl/en/publications/e6053af4-7c66-44a3-97bc-f7b87d1745a9
https://cris.maastrichtuniversity.nl/en/publications/e6053af4-7c66-44a3-97bc-f7b87d1745a9