Molecular Mechanisms of 5-Fluorocytosine Resistance in Yeasts and Filamentous Fungi

Autor: Fatima Zohra Delma, Abdullah M. S. Al-Hatmi, Roger J. M. Brüggemann, Willem J. G. Melchers, Sybren de Hoog, Paul E. Verweij, Jochem B. Buil

Publikováno v: Journal of Fungi, Vol 7, Iss 11, p 909 (2021)

Effective management and treatment of fungal diseases is hampered by poor diagnosis, limited options for antifungal therapy, and the emergence of antifungal drug resistance. An understanding of molecular mechanisms contributing to resistance is essen

Externí odkaz: https://doaj.org/article/3c6d6b39361d4dd599a285366b1341d7

Cyclosporine A trough concentrations are associated with acute GvHD after non-myeloablative allogeneic hematopoietic cell transplantation.

Autor: Elizabeth A de Kort, Heleen S de Lil, Manita E J Bremmers, Lenneke F J van Groningen, Nicole M A Blijlevens, Gerwin Huls, Roger J M Brüggemann, Suzanne van Dorp, Walter J F M van der Velden

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213913 (2019)

Low plasma CsA concentrations (

Externí odkaz: https://doaj.org/article/cf4555ffb54548dab6403ae5c2c1e22d

Ciprofloxacin Pharmacokinetics After Oral and Intravenous Administration in (Morbidly) Obese and Non-obese Individuals: A Prospective Clinical Study

Autor: Koen P. van Rhee, Cornelis Smit, Roeland E. Wasmann, Paul D. van der Linden, Rene Wiezer, Eric P. A. Van Dongen, Elke H. J. Krekels, Roger J. M. Brüggemann, Catherijne A. J. Knibbe

Publikováno v: Clinical Pharmacokinetics, 61, 1167-1175
Clinical Pharmacokinetics, 61, 8, pp. 1167-1175
Clinical Pharmacokinetics, 61(8), 1167-1175. ADIS INT LTD

Contains fulltext : 283110.pdf (Publisher’s version ) (Open Access) BACKGROUND AND OBJECTIVE: Ciprofloxacin is a fluoroquinolone used for empirical and targeted therapy of a wide range of infections. Despite the increase in obesity prevalence, only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c222b1c0890d19cb9afd5a76e83f206f
https://doi.org/10.1007/s40262-022-01130-5

A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology

Autor: Nico A. F. Janssen, Roger J. M. Brüggemann, Monique H. Reijers, Stefanie S. V. Henriet, Jaap ten Oever, Quirijn de Mast, Yvonne Berk, Elizabeth A. de Kort, Bart Jan Kullberg, Mihai G. Netea, Jochem B. Buil, Janette C. Rahamat-Langendoen, Didi Bury, Eline W. Muilwijk, Jacques F. Meis, Paul E. Verweij, Frank L. van de Veerdonk

Publikováno v: Journal of Fungi, Vol 6, Iss 4, p 274 (2020)

Invasive fungal diseases (IFDs) often represent complicated infections in complex patient populations. The Center of Expertise in Mycology Radboudumc/CWZ (EMRC) organizes a biweekly multidisciplinary mycology meeting to discuss patients with severe f

Externí odkaz: https://doaj.org/article/39b6af471081466c979734ba58264804

Multinational Observational Cohort Study of COVID-19–Associated Pulmonary Aspergillosis1

Autor: Josje Altenburg, Roger J. M. Brüggemann, Yves Debavaye, Joost Wauters, Saad Nseir, Catherine S. C. Bouman, Julien Maizel, Taieb Chouaki, Albert Dunbar, Niels Van Regenmortel, Lynn Rutsaert, Bart J. A. Rijnders, Boualem Sendid, Damien Costa, Jeroen Schouten, Marijke Reynders, Fabienne Tamion, Simon Feys, Lore Vanderbeke, Hervé Dupont, Katrien Lagrou, Nico A F Janssen, Rémy Nyga, Paul E. Verweij, Karin van Dijk, Marc Bourgeois, Cato Jacobs, Hans I van der Spoel, Frank L. van de Veerdonk, Jochem B. Buil, Mehmet Ergün, Piet Lormans

Publikováno v: Emerging Infectious Diseases, 27(11), 2892-2898. Centers for Disease Control and Prevention (CDC)
Emerging Infectious Diseases
Emerging Infectious Diseases, 2021, 27 (11), pp.2892-2898. ⟨10.3201/eid2711.211174⟩
Emerging Infectious Diseases, 27, 11, pp. 2892-2898
Emerging Infectious Diseases, 27, 2892-2898
Janssen, N A F, Nyga, R M, Vanderbeke, L, Jacobs, C, Ergün, M, Buil, J B, van Dijk, K, Altenburg, J, Bouman, C S C, van der Spoel, H I, Rijnders, B J A, Dunbar, A, Schouten, J A, Lagrou, K, Bourgeois, M, Reynders, M, van Regenmortel, N, Rutsaert, L, Lormans, P, Feys, S, Debavaye, Y, Tamion, F, Costa, D, Maizel, J, Dupont, H, Chouaki, T, Nseir, S, Sendid, B, Brüggemann, R J M, van de Veerdonk, F L, Wauters, J & Verweij, P E 2021, ' Multinational observational cohort study of covid-19-associated pulmonary aspergillosis1 ', Emerging Infectious Diseases, vol. 27, no. 11, pp. 2892-2898 . https://doi.org/10.3201/eid2711.211174

We performed an observational study to investigate intensive care unit incidence, risk factors, and outcomes of coronavirus disease-associated pulmonary aspergillosis (CAPA). We found 10%-15% CAPA incidence among 823 patients in 2 cohorts. Several fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c487d54a479f8d5385efc81e2c0cd508
https://doi.org/10.3201/eid2711.211174