Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Roger J Colbran"'
Autor:
H Scott Swartzwelder, Mary-Louise Risher, Kelsey M Miller, Roger J Colbran, Danny G Winder, Tiffany A Wills
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155951 (2016)
Adolescent alcohol use is the strongest predictor for alcohol use disorders. In rodents, adolescents have distinct responses to acute ethanol, and prolonged alcohol exposure during adolescence can maintain these phenotypes into adulthood. One brain r
Externí odkaz:
https://doaj.org/article/22f423c351c345c2b9985a880e1df523
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31554 (2012)
Mechanisms underlying age-dependent changes of dendritic spines on striatal medium spiny neurons are poorly understood. Spinophilin is an F-actin- and protein phosphatase 1 (PP1)-binding protein that targets PP1 to multiple downstream effectors to mo
Externí odkaz:
https://doaj.org/article/2655744e521f4dd9907cce742b6fc7ef
Autor:
Jason R Klug, Brian N Mathur, Thomas L Kash, Hui-Dong Wang, Robert T Matthews, A J Robison, Mark E Anderson, Ariel Y Deutch, David M Lovinger, Roger J Colbran, Danny G Winder
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45323 (2012)
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is abundant in striatal medium spiny neurons (MSNs). CaMKII is dynamically regulated by changes in dopamine signaling, as occurs in Parkinson's disease as well as addiction. Although CaMKII has b
Externí odkaz:
https://doaj.org/article/c6e9de7145f7401bbe18de3e0c26e8d7
Clustering of neuronal L-type voltage-gated Ca2+channels (LTCC) in the plasma membrane is increasingly implicated in creating highly localized Ca2+signaling nanodomains. For example, LTCC activation can increase phosphorylation of the nuclear CREB tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0d3ae785061ba8dd0faeb84779405a1
https://doi.org/10.1101/2022.10.21.513252
https://doi.org/10.1101/2022.10.21.513252
Publikováno v:
J Neurochem
Brain endocannabinoids serve as retrograde neurotransmitters, being synthesized in post-synaptic neurons "on demand" and released to bind pre-synaptic cannabinoid receptors and suppress glutamatergic or GABAergic transmission. The most abundant brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab943454c7a2ae427c1690f55aa444e
https://doi.org/10.1111/jnc.14972
https://doi.org/10.1111/jnc.14972
Publikováno v:
Biochem Biophys Res Commun
Protein-protein interactions can be modulated by phosphorylation of either binding partner, thereby altering subcellular localization and/or physiological function. Shank3, a master postsynaptic scaffolding protein that controls the developmental mat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f51ff6ecd5c824760044dfd20d1431f
https://doi.org/10.1016/j.bbrc.2020.01.089
https://doi.org/10.1016/j.bbrc.2020.01.089
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
Autor:
Terunaga Nakagawa, Tyler L. Perfitt, Jason R. Stephenson, Xiaohan Wang, David A. Jacobson, Matthew T. Dickerson, Roger J. Colbran
Publikováno v:
J Neurosci
The activation of neuronal plasma membrane Ca2+channels stimulates many intracellular responses. Scaffolding proteins can preferentially couple specific Ca2+channels to distinct downstream outputs, such as increased gene expression, but the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c039ffaebabbf87c652f2db4f714b696
https://doi.org/10.1523/jneurosci.0893-19.2020
https://doi.org/10.1523/jneurosci.0893-19.2020
Autor:
Richard M. Gustin, Terry Jo Bichell, Michael Bubser, Jennifer Daily, Irina Filonova, Davit Mrelashvili, Ariel Y. Deutch, Roger J. Colbran, Edwin J. Weeber, Kevin F. Haas
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 3, Pp 283-291 (2010)
Angelman syndrome (AS) is a neurogenetic disorder caused by loss of maternal UBE3A expression or mutation-induced dysfunction of its protein product, the E3 ubiquitin–protein ligase, UBE3A. In humans and rodents, UBE3A/Ube3a transcript is maternall
Externí odkaz:
https://doaj.org/article/a3facd51343c42d4bb123b0d1c26e81d
Autor:
Jason R. Stephenson, Xiaohan Wang, Roger J. Colbran, Christian R. Marks, Brian C. Shonesy, Colleen M. Niswender
Publikováno v:
Molecular Pharmacology. 94:1352-1362
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and metabotropic glutamate receptor 5 (mGlu(5)) are critical signaling molecules in synaptic plasticity and learning/memory. Here, we demonstrate that mGlu(5) is present in CaMKIIα complexes iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f5cdb087a6ab1a9f013bfa68a9c160
https://doi.org/10.1124/mol.118.113142
https://doi.org/10.1124/mol.118.113142
Autor:
Oakleigh M. Folkes, Danny G. Winder, Ken Mackie, Shana M. Augustin, Walker P. Parrish, Samuel W. Centanni, Jason R. Stephenson, Roger J. Colbran, David M. Lovinger, Hala K. Haddad, Sachin Patel, Brian C. Shonesy, Keeley L. Spiess, Rebecca J. Bluett, Rita Báldi, Christian R. Marks
Publikováno v:
Biological Psychiatry. 84:304-315
Background Endocannabinoid signaling plays an important role in regulating synaptic transmission in the striatum, a brain region implicated as a central node of dysfunction in autism spectrum disorder. Deficits in signaling mediated by the endocannab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4bdda1437b5ca7db890d38e5a9f033
https://doi.org/10.1016/j.biopsych.2017.11.036
https://doi.org/10.1016/j.biopsych.2017.11.036