Zobrazeno 1 - 10
of 698
pro vyhledávání: '"Roger J, Hajjar"'
Autor:
Shu-hao Liou, Rajendra Boggavarapu, Noah R. Cohen, Yue Zhang, Ishwari Sharma, Lynn Zeheb, Nidhi Mukund Acharekar, Hillary D. Rodgers, Saadman Islam, Jared Pitts, Cesar Arze, Harish Swaminathan, Nathan Yozwiak, Tuyen Ong, Roger J. Hajjar, Yong Chang, Kurt A. Swanson, Simon Delagrave
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Anelloviruses are nonpathogenic viruses that comprise a major portion of the human virome. Despite being ubiquitous in the human population, anelloviruses (ANVs) remain poorly understood. Basic features of the virus, such as the identity of
Externí odkaz:
https://doaj.org/article/e9feceb20c5447e1933ccba332f71551
Autor:
Sacha V. Kepreotis, Jae Gyun Oh, Mina Park, Jimeen Yoo, Cholong Lee, Mark Mercola, Roger J. Hajjar, Dongtak Jeong
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102174- (2024)
Dystrophic cardiomyopathy is a significant feature of Duchenne muscular dystrophy (DMD). Increased cardiomyocyte cytosolic calcium (Ca2+) and interstitial fibrosis are major pathophysiological hallmarks that ultimately result in cardiac dysfunction.
Externí odkaz:
https://doaj.org/article/1cc3305bec1144ec93e2670c9a1ac745
Autor:
Min Ho Song, Jimeen Yoo, Do-A Kwon, Elena Chepurko, Sunghye Cho, Anthony Fargnoli, Roger J. Hajjar, Woo Jin Park, Lior Zangi, Dongtak Jeong
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6262 (2024)
Modified mRNAs (modRNAs) are an emerging delivery method for gene therapy. The success of modRNA-based COVID-19 vaccines has demonstrated that modRNA is a safe and effective therapeutic tool. Moreover, modRNA has the potential to treat various human
Externí odkaz:
https://doaj.org/article/b4c1c528d555464bb8c9ffd860c1ad36
Autor:
Manuel Ramos-Kuri, Sri Harika Meka, Fabio Salamanca-Buentello, Roger J. Hajjar, Larissa Lipskaia, Elie R. Chemaly
Publikováno v:
Biological Research, Vol 54, Iss 1, Pp 1-14 (2021)
Highlights The Ras (Rat Sarcoma) gene family is a group of small G proteins Ras is regulated by growth factors and neurohormones affecting cardiomyocyte growth and hypertrophy Ras directly affects cardiomyocyte physiological and pathological hypertro
Externí odkaz:
https://doaj.org/article/504865b60c394a5b8a209fd43584e51d
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
Myocardial delivery of human c-kit+ cardiac interstitial cells (hCICs) and human mesenchymal stem cells (hMSCs), an emerging approach for treating the failing heart, has been limited by an incomplete understanding of the effects on host myocardium. T
Externí odkaz:
https://doaj.org/article/6aa6604fbc764ca5a9907d20aeb66e24
Autor:
Mohit Kumar, Kobra Haghighi, Sheryl Koch, Jack Rubinstein, Francesca Stillitano, Roger J. Hajjar, Evangelia G. Kranias, Sakthivel Sadayappan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2675 (2023)
Phospholamban (PLN) is a major regulator of cardiac contractility, and human mutations in this gene give rise to inherited cardiomyopathies. The deletion of Arginine 14 is the most-prevalent cardiomyopathy-related mutation, and it has been linked to
Externí odkaz:
https://doaj.org/article/c3e75532ebfe4737b2a1a4a70797679d
Autor:
Jack F. Murphy, Joshua Mayourian, Francesca Stillitano, Sadek Munawar, Kathleen M. Broughton, Esperanza Agullo-Pascual, Mark A. Sussman, Roger J. Hajjar, Kevin D. Costa, Irene C. Turnbull
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-19 (2019)
Abstract Background Delivery of stem cells to the failing heart is a promising therapeutic strategy. However, the improvement in cardiac function in animal studies has not fully translated to humans. To help bridge the gap between species, we investi
Externí odkaz:
https://doaj.org/article/9a9bde06e28e4ec3b138f70b770bbe62
Autor:
Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J. McArdle, Louis J. Dell’Italia, Jerry R. Mendell, Lai-Hua Xie, Roger J. Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J. Babu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Sarcolipin is an inhibitor of the ATP dependent calcium pump SERCA, and is abnormally elevated in Duchenne muscular dystrophy. The authors show that reducing sarcolipin expression ameliorates skeletal muscle pathology and cardiomyopathy and extends l
Externí odkaz:
https://doaj.org/article/201501e20c1241caab7a1010c329171a
Autor:
Delaine K. Ceholski, Irene C. Turnbull, Venu Pothula, Laura Lecce, Andrew A. Jarrah, Changwon Kho, Ahyoung Lee, Lahouaria Hadri, Kevin D. Costa, Roger J. Hajjar, Sima T. Tarzami
Publikováno v:
Stem Cell Research, Vol 23, Iss C, Pp 77-86 (2017)
CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adren
Externí odkaz:
https://doaj.org/article/11c97dd43e1a49a3bf1a34fac3717cdb
Autor:
Lukas J. Motloch, MD, PhD, Kiyotake Ishikawa, MD, Chaoqin Xie, MD, Jun Hu, PhD, Jaume Aguero, MD, Kenneth M. Fish, PhD, Roger J. Hajjar, MD, Fadi G. Akar, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 3, Pp 258-269 (2017)
Summary: Although the pathophysiological significance of resistant hypertension in postâmyocardial infarction (MI) patients is established, the mechanisms by which increased afterload in that setting worsens outcome are unclear. With regard to sudde
Externí odkaz:
https://doaj.org/article/567e3ad87774479d87bf53f3def6720d