Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Roger H Johnson"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009949 (2022)
Automatic characterization of fluorescent labeling in intact mammalian tissues remains a challenge due to the lack of quantifying techniques capable of segregating densely packed nuclei and intricate tissue patterns. Here, we describe a powerful deep
Externí odkaz:
https://doaj.org/article/5044be5b25b447c88f08881c256a3156
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e75365 (2013)
Cellular heterogeneity plays a pivotal role in a variety of functional processes in vivo including carcinogenesis. However, our knowledge about cell-to-cell diversity and how differences in individual cells manifest in alterations at the population l
Externí odkaz:
https://doaj.org/article/476dc4e1f2cc428494d89b53d1668589
Autor:
Fengyu Su, Ruhaniyah Alam, Qian Mei, Yanqing Tian, Cody Youngbull, Roger H Johnson, Deirdre R Meldrum
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33390 (2012)
Hydrophobic platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) was physically incorporated into micelles formed from poly(ε-caprolactone)-block-poly(ethylene glycol) to enable the application of PtTFPP in aqueous solut
Externí odkaz:
https://doaj.org/article/9091ab81ad3e457588a380885f620c49
Autor:
Vivek Nandakumar, Laimonas Kelbauskas, Kathryn F Hernandez, Kelly M Lintecum, Patti Senechal, Kimberly J Bussey, Paul C W Davies, Roger H Johnson, Deirdre R Meldrum
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29230 (2012)
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with features that are i
Externí odkaz:
https://doaj.org/article/6d241f2238ac4f4b90a7364b6123a1db
Autor:
Sherry-Ann Brown, Rodney Sparapani, Kristen Osinski, Jun Zhang, Jeffrey Blessing, Feixiong Cheng, Abdulaziz Hamid, Mehri Bagheri MohamadiPour, Jessica Castrillon Lal, Anai N. Kothari, Pedro Caraballo, Peter Noseworthy, Roger H. Johnson, Kathryn Hansen, Louise Y. Sun, Bradley Crotty, Yee Chung Cheng, Gift Echefu, Krishna Doshi, Jessica Olson
Publikováno v:
American Heart Journal Plus, Vol 32, Iss , Pp 100306- (2023)
Interdisciplinary research teams can be extremely beneficial when addressing difficult clinical problems. The incorporation of conceptual and methodological strategies from a variety of research disciplines and health professions yields transformativ
Externí odkaz:
https://doaj.org/article/210eeffc0f48419c8be57ee588ef4c77
Autor:
Xueliang Gao, Yongxia Wu, Joel M. Chick, Andrea Abbott, Baishan Jiang, David J. Wang, Susana Comte-Walters, Roger H. Johnson, Nathaniel Oberholtzer, Michael I. Nishimura, Steven P. Gygi, Anand Mehta, Denis C. Guttridge, Lauren Ball, Shikhar Mehrotra, Piotr Sicinski, Xue-Zhong Yu, Haizhen Wang
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112314- (2023)
Summary: Elucidating the mechanisms of resistance to immunotherapy and developing strategies to improve its efficacy are challenging goals. Bioinformatics analysis demonstrates that high CDK6 expression in melanoma is associated with poor progression
Externí odkaz:
https://doaj.org/article/d8061c0240544238ba7cf4290e1b4efe
Autor:
Sherry-Ann Brown, Rodney Sparapani, Kristen Osinski, Jun Zhang, Jeffrey Blessing, Feixiong Cheng, Abdulaziz Hamid, Generika Berman, Kyla Lee, Mehri BagheriMohamadiPour, Jessica Castrillon Lal, Anai N. Kothari, Pedro Caraballo, Peter Noseworthy, Roger H. Johnson, Kathryn Hansen, Louise Y. Sun, Bradley Crotty, Yee Chung Cheng, Jessica Olson
Publikováno v:
American Heart Journal Plus, Vol 13, Iss , Pp 100094- (2022)
Study objective: A multi-institutional interdisciplinary team was created to develop a research group focused on leveraging artificial intelligence and informatics for cardio-oncology patients. Cardio-oncology is an emerging medical field dedicated t
Externí odkaz:
https://doaj.org/article/23aaf375d1e947bc830a313861b4815b
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, 2022, 18 (3), pp.e1009949. ⟨10.1371/journal.pcbi.1009949⟩
PLoS Computational Biology, 2022, 18 (3), pp.e1009949. ⟨10.1371/journal.pcbi.1009949⟩
Automatic characterization of fluorescent labeling in intact mammalian tissues remains a challenge due to the lack of quantifying techniques capable of segregating densely packed nuclei and intricate tissue patterns. Here, we describe a powerful deep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af73215fb61fa1650fc850432c4a7eb
https://hal.science/hal-03632329/document
https://hal.science/hal-03632329/document
Autor:
Chen Chu, Kenneth D. Tew, Xue-Zhong Yu, Gustavo Leone, Xueliang Gao, Shenghui Qin, Jie Zhang, Haizhen Wang, Xi Wang, Anand Mehta, Dong Kuang, Baishan Jiang, Yongxia Wu, Roger H. Johnson
Publikováno v:
Journal of Clinical Investigation. 131
PFKP (phosphofructokinase, platelet), the major isoform of PFK1 expressed in T cell acute lymphoblastic leukemia (T-ALL), is predominantly expressed in the cytoplasm to carry out its glycolytic function. Our study showed that PFKP is a nucleocytoplas
Publikováno v:
Crit Rev Biochem Mol Biol
The fragile X-related (FXR) family proteins FMRP, FXR1, and FXR2 are RNA binding proteins that play a critical role in RNA metabolism, neuronal plasticity, and muscle development. These proteins share significant homology in their protein domains, wh