Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Roger H Brookes"'
Autor:
Bing Li, Irina V. Ustyugova, Lisa Szymkowicz, Shaolong Zhu, Marin Ming, Karen Y. Y. Fung, Guadalupe Cortés, D. Andrew James, Michael Hrynyk, Nausheen Rahman, Roger H. Brookes, Salvador F. Ausar
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
ABSTRACTCurrent influenza vaccines could be augmented by including recombinant neuraminidase (rNA) protein antigen to broaden protective immunity and improve efficacy. Toward this goal, we investigated formulation conditions to optimize rNA physicoch
Externí odkaz:
https://doaj.org/article/b9a83ae88c824934944cdcb2de84a9be
Autor:
Roger H Brookes, Philip C Hill, Patrick K Owiafe, Hannah B Ibanga, David J Jeffries, Simon A Donkor, Helen A Fletcher, Abdulrahman S Hammond, Christian Lienhardt, Richard A Adegbola, Helen McShane, Adrian V S Hill
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2921 (2008)
Vaccination with a recombinant modified vaccinia Ankara expressing antigen 85A from Mycobacterium tuberculosis, MVA85A, induces high levels of cellular immune responses in UK volunteers. We assessed the safety and immunogenicity of this new vaccine i
Externí odkaz:
https://doaj.org/article/697f4bd9c458402b84d34e49123f0eb1
Autor:
Philip C Hill, Dolly J Jackson-Sillah, Annette Fox, Roger H Brookes, Bouke C de Jong, Moses D Lugos, Ifedayo M Adetifa, Simon A Donkor, Alex M Aiken, Stephen R Howie, Tumani Corrah, Keith P McAdam, Richard A Adegbola
Publikováno v:
PLoS ONE, Vol 3, Iss 1, p e1379 (2008)
Studies of Tuberculosis (TB) case contacts are increasingly being utilised for understanding the relationship between M. tuberculosis and the human host and for assessing new interventions and diagnostic tests. We aimed to identify the incidence rate
Externí odkaz:
https://doaj.org/article/1451d781c28c4d5c80ccf001cecc3dbd
Autor:
Philip C Hill, Roger H Brookes, Annette Fox, Dolly Jackson-Sillah, David J Jeffries, Moses D Lugos, Simon A Donkor, Ifedayo M Adetifa, Bouke C de Jong, Alex M Aiken, Richard A Adegbola, Keith P McAdam
Publikováno v:
PLoS Medicine, Vol 4, Iss 6, p e192 (2007)
Very little longitudinal information is available regarding the performance of T cell-based tests for Mycobacterium tuberculosis infection. To address this deficiency, we conducted a longitudinal assessment of the enzyme-linked immunosorbent spot tes
Externí odkaz:
https://doaj.org/article/7bf66ab6438d4702bb4500652f062723
Autor:
Philip C Hill, David J Jeffries, Roger H Brookes, Annette Fox, Dolly Jackson-Sillah, Moses D Lugos, Simon A Donkor, Bouke C de Jong, Tumani Corrah, Richard A Adegbola, Keith P McAdam
Publikováno v:
PLoS ONE, Vol 2, Iss 1, p e183 (2007)
BACKGROUND:Repeat tuberculin skin tests may be false positive due to boosting of waned immunity to past mycobacterial exposure. We evaluated whether an ELISPOT test could identify tuberculosis (TB) contacts with boosting of immunity to non-tuberculou
Externí odkaz:
https://doaj.org/article/08b9fcd029894f1bb38c382bc87a2d8f
Autor:
Philip C Hill, Roger H Brookes, Annette Fox, Dolly Jackson-Sillah, Moses D Lugos, David J Jeffries, Simon A Donkor, Richard A Adegbola, Keith P W J McAdam
Publikováno v:
PLoS ONE, Vol 1, p e68 (2006)
Options for intervention against Mycobacterium tuberculosis infection are limited by the diagnostic tools available. The Purified Protein Derivative (PPD) skin test is thought to be non-specific, especially in tropical settings. We compared the PPD s
Externí odkaz:
https://doaj.org/article/cf8f283980074e4ea82f550460d33182
Autor:
Jalil Hakimi, Ali Azizi, Salvador F. Ausar, Stephen M. Todryk, Nausheen Rahman, Roger H. Brookes
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 13, Iss 9, Pp 2130-2134 (2017)
The restimulation of an immune memory response by in vitro culture of blood cells with a specific antigen has been used as a way to gauge immunity to vaccines for decades. In this commentary we discuss a less appreciated application to support vaccin
Externí odkaz:
https://doaj.org/article/f6f1a91cb79943e586555a225487715d
Autor:
Javier R. Jaldin‐Fincati, Serene Moussaoui, Maria Cecilia Gimenez, Cheuk Y. Ho, Charlene E. Lancaster, Roberto J. Botelho, Salvador F. Ausar, Roger H. Brookes, Mauricio R. Terebiznik
Publikováno v:
Molecular Microbiology. 117:1173-1195
Aluminum salts have been successfully utilized as adjuvants to enhance the immunogenicity of vaccine antigens since the 1930s. However, the cellular mechanisms behind the immune adjuvanticity effect of these materials in antigen-presenting cells are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dd9e31a0d41f55b76218b10ec2b67
https://doi.org/10.1111/mmi.14900
https://doi.org/10.1111/mmi.14900
Autor:
Derek J. Wilson, Stephen Li, Salvador F. Ausar, Thomas Bertrand, Jessica Duprez, Roger H. Brookes, Alexey Rak, D. Andrew James, Artur Pedyczak, Shaolong Zhu, Valerie Steier, Anthony Sheung, Michael X Cohen
Publikováno v:
Communications Biology
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)
The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein structure and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c21e5acfc882add69441d72d08636b
http://europepmc.org/articles/PMC7406505
http://europepmc.org/articles/PMC7406505
Autor:
Jessica Duprez, Stephen Li, Roger H. Brookes, Michael S. Cohen, Derek J. Wilson, D. Andrew James
Publikováno v:
Journal of Immunological Methods. 495:113083
The ability to measure immunomodulatory effects of a vaccine is crucial for novel vaccine design. While traditional animal models have been effective, a better understanding of the response in humans to new vaccines in pre-clinical development is cri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7063a480f5905bdcf140ab6c1df562d
https://doi.org/10.1016/j.jim.2021.113083
https://doi.org/10.1016/j.jim.2021.113083