Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Roger Gilabert-Oriol"'
Autor:
Roger Gilabert-Oriol, Mayank Thakur, Benedicta von Mallinckrodt, Cheenu Bhargava, Burkhard Wiesner, Jenny Eichhorst, Matthias F. Melzig, Hendrik Fuchs, Alexander Weng
Publikováno v:
Toxins, Vol 6, Iss 5, Pp 1644-1666 (2014)
Protein-based therapeutics with cytosolic targets are capable of exhibiting their therapeutic effect once they have escaped from the endosomes or lysosomes. In this study, the reporters—horseradish peroxidase (HRP), Alexa Fluor 488 (Alexa) and rici
Externí odkaz:
https://doaj.org/article/56e0e86d132a4591bdaf9cfe44c3e733
Publikováno v:
Toxins, Vol 8, Iss 7, p 200 (2016)
The toxic moiety of almost all protein-based targeted toxins must enter the cytosol of the target cell to mediate its fatal effect. Although more than 500 targeted toxins have been investigated in the past decades, no antibody-targeted protein toxin
Externí odkaz:
https://doaj.org/article/0c3bd0a5541f44459cb4f2867d1cae8e
Autor:
Alexander Weng, Andrew W. Boyd, David L Hare, Brett W. Stringer, Roger Gilabert-Oriol, Angela Kourakis, Mayank Thakur, Sebastian G.B. Furness, Hendrik Fuchs, Terrance Grant Johns, Bryan W. Day, Peter J. Wookey
Publikováno v:
Cancer Immunology, Immunotherapy. 66:1217-1228
We have reported that calcitonin receptor (CTR) is widely expressed in biopsies from the lethal brain tumour glioblastoma by malignant glioma and brain tumour-initiating cells (glioma stem cells) using anti-human CTR antibodies. A monoclonal antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733ee260c4fe59bfd854e61852f448d6
https://doi.org/10.1007/s00262-017-2013-z
https://doi.org/10.1007/s00262-017-2013-z
Publikováno v:
Drug Delivery and Translational Research. 7:544-557
Topotecan is a drug that is under investigation for the treatment of neuroblastoma and has been encapsulated into liposomes to improve its therapeutic efficacy. However, liposomal formulations still need to be optimized for drug retention and new tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de9fbbd7bd8be73bdc2968ff13ef1eb
https://doi.org/10.1007/s13346-017-0380-9
https://doi.org/10.1007/s13346-017-0380-9
Autor:
Heroux Devon, Roger Gilabert-Oriol, Michael J. Abrams, Tom R Redelmier, Marcel B. Bally, Ada Wy Leung, Kent Chen
Publikováno v:
Oncology Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b088fa79d98637b82ababab192039aa
https://doi.org/10.1530/oncolabs.1.p003
https://doi.org/10.1530/oncolabs.1.p003
Publikováno v:
Pharmaceutical Research
Acute myeloid leukemia (AML) is the most common acute leukemia that is becoming more prevalent particularly in the older (65 years of age or older) population. For decades, “7 + 3” remission induction therapy with cytarabine and an anthracycline,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d8b89693f4b363a3ef2958ac064f05
https://doi.org/10.1007/s11095-019-2654-z
https://doi.org/10.1007/s11095-019-2654-z
Autor:
Alessia Pallaoro, Roger Gilabert-Oriol, Brent W. Sutherland, Malathi Anantha, Marcel B. Bally
Publikováno v:
Drug delivery and translational research. 9(6)
OTS964 is an inhibitor of T-lymphokine-activated killer cell-originated protein kinase (TOPK), a protein kinase important for mitosis and highly expressed in ovarian and lung cancers. This compound demonstrated potent anti-proliferative activity in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd644ec9b528eb30d38d32e0eccd8627
https://pubmed.ncbi.nlm.nih.gov/31209826
https://pubmed.ncbi.nlm.nih.gov/31209826
Autor:
Roger Gilabert-Oriol, Nicole Niesler, Cornelia Görick, Hendrik Fuchs, Alexander Weng, Katy Haussmann, Cheenu Bhargava, Mayank Thakur
Publikováno v:
Planta Medica. 82:1525-1531
Triterpenoidal saponins are synthesized in the roots of Saponaria officinalis L. The same plant is also a source for the toxin Saporin, which is a ribosome-inactivating protein. Triterpenoidal saponins are known to increase the cytotoxicity of Sapori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb6ae24e0d5b2b044b5e3aeccb457bb
https://doi.org/10.1055/s-0042-110495
https://doi.org/10.1055/s-0042-110495
Autor:
Marcel B. Bally, Gemma M. Ryan, Kevin L. Bennewith, Ada W. Y. Leung, Roger Gilabert-Oriol, Natalie S. Firmino
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 2922 (2018)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Tumours are complex systems of genetically diverse malignant cells that proliferate in the presence of a heterogeneous microenvironment consisting of host derived microvasculature, stromal, and immune cells. The components of the tumour microenvironm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d49cab0c91948befe50a35e14ff15ca
http://www.mdpi.com/1422-0067/19/10/2922
http://www.mdpi.com/1422-0067/19/10/2922
Neuroblastoma is the most common extracranial solid tumor of infancy and remains a leading cause of childhood cancer-related mortality at the time when this chapter was prepared (end of 2016). It is a highly heterogeneous disease that originates in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a699e50b3918e47e16dc72fd239870c7
https://doi.org/10.1016/b978-0-12-813687-4.00009-8
https://doi.org/10.1016/b978-0-12-813687-4.00009-8
