Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Roger G. Ulrich"'
Autor:
Xudong Dai, Angus T De Souza, Hongyue Dai, David L Lewis, Chang-kyu Lee, Andy G Spencer, Hans Herweijer, Jim E Hagstrom, Peter S Linsley, Douglas E Bassett, Roger G Ulrich, Yudong D He
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 3, p e30 (2007)
Uncovering pathways underlying drug-induced toxicity is a fundamental objective in the field of toxicogenomics. Developing mechanism-based toxicity biomarkers requires the identification of such novel pathways and the order of their sufficiency in ca
Externí odkaz:
https://doaj.org/article/4bbedddb2b9044bea8ea3ca7ee5ebb5e
Autor:
Michael B. Raizman, Francis S. Mah, Roger G. Ulrich, Pedram Hamrah, Terry Kim, Christopher J. Rapuano, Edward J. Holland
Publikováno v:
Survey of Ophthalmology. 62:286-301
Drugs across many pharmacologic classes induce corneal epithelial changes. Many of these drugs have cationic amphiphilic structures, with a hydrophobic ring and hydrophilic cationic amine side chain that allow them to cross cell membranes. These drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5e1028a2863f683ba3ded38925254a
https://doi.org/10.1016/j.survophthal.2016.11.008
https://doi.org/10.1016/j.survophthal.2016.11.008
Publikováno v:
The Control of Aggression ISBN: 9781315080390
The Control of Aggression
The Control of Aggression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ddcad8159d78cdf8069f7b47455c168
https://doi.org/10.4324/9781315080390-4
https://doi.org/10.4324/9781315080390-4
Autor:
Dennis Demont, Roger G. Ulrich, Tjeerd Barf, Raquel Izumi, Allard Kaptein, Bart Van Lith, Edwin de Zwart, Michael Gulrajani, Todd Covey, Saskia Verkaik, Paul G. Pearson, Diana Mittag, Bas van de Kar, Fanny Krantz, Maaike van Hoek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(2)
Several small-molecule Bruton tyrosine kinase (BTK) inhibitors are in development for B cell malignancies and autoimmune disorders, each characterized by distinct potency and selectivity patterns. Herein we describe the pharmacologic characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2c688d3e7529373fba9017b6688ca0
https://pubmed.ncbi.nlm.nih.gov/28882879
https://pubmed.ncbi.nlm.nih.gov/28882879
Autor:
Fanny Krantz, Dolors Colomer, Raquel Izumi, Jennifer A. Woyach, Bonnie K. Harrington, Arnau Montraveta, Sarah E. M. Herman, Carsten Utoft Niemann, Fabienne McClanahan, Amy J. Johnson, Lisa L. Smith, Todd Covey, Brian J. Lannutti, Roger G. Ulrich, Helena Mora-Jensen, Rose Mantel, Adrian Wiestner, Allard Kaptein, Michael Gulrajani, John C. Byrd
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 23(11)
Purpose: Acalabrutinib (ACP-196) is a novel, potent, and highly selective Bruton tyrosine kinase (BTK) inhibitor, which binds covalently to Cys481 in the ATP-binding pocket of BTK. We sought to evaluate the antitumor effects of acalabrutinib treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea08a03b712302cd7c1896073b6f12ef
https://pubmed.ncbi.nlm.nih.gov/27903679
https://pubmed.ncbi.nlm.nih.gov/27903679
Autor:
Amy J. Johnson, Sarah E. M. Herman, Jeffrey W. Tyner, Sarah A. Meadows, Adam Kashishian, Bart Steiner, Brian J. Lannutti, Brian J. Druker, Kamal D. Puri, John C. Byrd, Neill A. Giese, Mike Deininger, Marc M. Loriaux, Roger G. Ulrich
Publikováno v:
Blood. 117:591-594
Phosphatidylinositol-3-kinase p110δ serves as a central integration point for signaling from cell surface receptors known to promote malignant B-cell proliferation and survival. This provides a rationale for the development of small molecule inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34aea9a4e821facb44aee255ca627137
https://doi.org/10.1182/blood-2010-03-275305
https://doi.org/10.1182/blood-2010-03-275305
Publikováno v:
Journal of Applied Physiology. 107:605-612
Muscle responses to exercise are complex and include acute responses to exercise-induced injury, as well as longer term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38848db81b34b9f6ad47b08e73b84eec
https://doi.org/10.1152/japplphysiol.91347.2008
https://doi.org/10.1152/japplphysiol.91347.2008
Autor:
Paul D. Cornwell, Roger G. Ulrich
Publikováno v:
Toxicologic Pathology. 35:576-588
A compendium of hepatic gene expression signatures was used to identify a mechanistic basis for the hepatic toxicity of an experimental CCR5 antagonist (MrkA). Development of MrkA, a potential HIV therapeutic, was discontinued due to hepatotoxicity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb24913b90dcff927d80399d4abac4b
https://doi.org/10.1080/01926230701383194
https://doi.org/10.1080/01926230701383194
Autor:
Angus T. De Souza, Tom W. Reppen, Xudong Dai, Hans Herweijer, Paula L. Roesch, Michelle J. Caguyong, Sherri Bloomer, Roger G. Ulrich, A.M. Menzie, Peter S. Linsley, James E. Hagstrom, David L. Lewis, Andrew G Spencer, Yudong He, Jon A. Wolff
Publikováno v:
Nucleic Acids Research
RNA interference (RNAi) has great potential as a tool for studying gene function in mammals. However, the specificity and magnitude of the in vivo response to RNAi remains to be fully characterized. A molecular and phenotypic comparison of a genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3615dd64f1ae3cf5dd51b92e63d1ceab
https://doi.org/10.1093/nar/gkl609
https://doi.org/10.1093/nar/gkl609
Publikováno v:
Toxicological Sciences. 92:578-586
In rodents, treatment with peroxisome proliferator-activated receptor alpha (PPARalpha) agonists results in peroxisome proliferation, hepatocellular hypertrophy, and hepatomegaly. Drugs in the fibrate class of PPARalpha agonists have also been report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527c045dd00f7a0ea19a1b196ad28d13
https://doi.org/10.1093/toxsci/kfl019
https://doi.org/10.1093/toxsci/kfl019