Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Roger G Ptak"'
Autor:
Elizabeth R Wonderlich, Krupa Subramanian, Bryan Cox, Ann Wiegand, Carol Lackman-Smith, Michael J Bale, Mars Stone, Rebecca Hoh, Mary F Kearney, Frank Maldarelli, Steven G Deeks, Michael P Busch, Roger G Ptak, Deanna A Kulpa
Publikováno v:
PLoS Pathogens, Vol 15, Iss 10, p e1008074 (2019)
Studies have demonstrated that intensive ART alone is not capable of eradicating HIV-1, as the virus rebounds within a few weeks upon treatment interruption. Viral rebound may be induced from several cellular subsets; however, the majority of provira
Externí odkaz:
https://doaj.org/article/b946644f3bfc4fa590e2e7f8db0f9f8c
Autor:
Daniel I S Rosenbloom, Peter Bacchetti, Mars Stone, Xutao Deng, Ronald J Bosch, Douglas D Richman, Janet D Siliciano, John W Mellors, Steven G Deeks, Roger G Ptak, Rebecca Hoh, Sheila M Keating, Melanie Dimapasoc, Marta Massanella, Jun Lai, Michele D Sobolewski, Deanna A Kulpa, Michael P Busch, Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006849 (2019)
Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4+ T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing HIV-1. Efforts to reduce the reservoir require assays that can reliably quantify its size
Externí odkaz:
https://doaj.org/article/b5955aac1a054bdaae557617f2bee089
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0192512 (2018)
The HIV-1 Nef accessory protein is essential for viral pathogenicity and AIDS progression. Nef forms complexes with multiple host cell factors to facilitate viral replication and promote immune escape of HIV-infected cells. Previous X-ray crystal str
Externí odkaz:
https://doaj.org/article/564aed6d3abd4a31b9cd553127b94b80
Autor:
Olga A Nikolaitchik, Kari A Dilley, William Fu, Robert J Gorelick, S-H Sheldon Tai, Ferri Soheilian, Roger G Ptak, Kunio Nagashima, Vinay K Pathak, Wei-Shau Hu
Publikováno v:
PLoS Pathogens, Vol 9, Iss 3, p e1003249 (2013)
How retroviruses regulate the amount of RNA genome packaged into each virion has remained a long-standing question. Our previous study showed that most HIV-1 particles contain two copies of viral RNA, indicating that the number of genomes packaged is
Externí odkaz:
https://doaj.org/article/6c5193d48ad84355b3127114444ac64a
Autor:
Natalia Pripuzova, Richard Wang, Shien Tsai, Bingjie Li, Guo-Chiuan Hung, Roger G Ptak, Shyh-Ching Lo
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43246 (2012)
BACKGROUND: Real-time PCR array for rapid detection of multiple viral pathogens should be highly useful in cases where the sample volume and the time of testing are limited, i.e. in the eligibility testing of tissue and organ donors. FINDINGS: We dev
Externí odkaz:
https://doaj.org/article/a686f36df7084695a1a5c3c2ff3981d4
Autor:
Yury V. Kuzmichev, Carol Lackman-Smith, Sonia Bakkour, Ann Wiegand, Michael J. Bale, Andrew Musick, Wendy Bernstein, Naomi Aronson, Julie Ake, Sodsai Tovanabutra, Mars Stone, Roger G. Ptak, Mary F. Kearney, Michael P. Busch, Elizabeth R. Wonderlich, Deanna A. Kulpa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The advent of combined antiretroviral therapy (cART) has been instrumental in controlling HIV-1 replication and transmission and decreasing associated morbidity and mortality. However, cART alone is not able to cure HIV-1 due to the presence
Externí odkaz:
https://doaj.org/article/545480fa87244f56b8e17d09e2796b5a
Publikováno v:
Advances in Virology, Vol 2020 (2020)
Approximately 257 million people chronically infected with hepatitis B virus (HBV) worldwide are at risk of developing hepatocellular carcinoma (HCC). However, despite the availability of potent nucleoside/tide inhibitors, currently there are no cura
Externí odkaz:
https://doaj.org/article/c98647cde287425a892e25fb46e2df04
Autor:
Lori A. Emert-Sedlak, Omar Moukha-Chafiq, Haibin Shi, Shoucheng Du, John J. Alvarado, Vibha Pathak, Samuel G. Tanner, Robert N. Hunter, Miranda Nebane, Li Chen, Tatiana V. Ilina, Rieko Ishima, Sixue Zhang, Yury V. Kuzmichev, Elizabeth R. Wonderlich, Susan M. Schader, Corinne E. Augelli-Szafran, Roger G. Ptak, Thomas E. Smithgall
Publikováno v:
ACS Infect Dis
HIV-1 Nef is an attractive target for antiretroviral drug discovery because of its roles promoting HIV-1 infectivity, replication, and host immune system avoidance. Here we applied a screening strategy in which recombinant HIV-1 Nef protein was coupl
Publikováno v:
RSC Medicinal Chemistry. 12:804-808
The substantial impact of acyclic nucleoside phosphonates (ANPs) on human medicine encourages the synthesis of new ANP analogues with a potentially differentiated antiviral spectrum. Herein, we demonstrate the functionalization of the 2-position of t
Publikováno v:
Advances in Virology
Advances in Virology, Vol 2020 (2020)
Advances in Virology, Vol 2020 (2020)
Approximately 257 million people chronically infected with hepatitis B virus (HBV) worldwide are at risk of developing hepatocellular carcinoma (HCC). However, despite the availability of potent nucleoside/tide inhibitors, currently there are no cura