Výsledky vyhledávání - "Roger G, Spragg"

Akademický článek

Association Between Acute Kidney Injury During Invasive Mechanical Ventilation and ICU Outcomes and Respiratory System Mechanics

Autor: Sneha V. Vemuri, MBChB, Mark L. Rolfsen, MD, Alexandra V. Sykes, MD, Puja G. Takiar, MD, Austin J. Leonard, BA, Atul Malhotra, MD, Roger G. Spragg, MD, Etienne Macedo, MD, PhD, Mark L. Hepokoski, MD

Publikováno v: Critical Care Explorations, Vol 4, Iss 7, p e0720 (2022)

OBJECTIVES:. Compare ICU outcomes and respiratory system mechanics in patients with and without acute kidney injury during invasive mechanical ventilation. DESIGNS:. Retrospective cohort study. SETTINGS:. ICUs of the University of California, San Die

Externí odkaz: https://doaj.org/article/033cb83ceec444f69abb41970cbc4c5e

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Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions

Publikováno v: American journal of physiology. Lung cellular and molecular physiology. 323(1)

Increased plasma mitochondrial DNA concentrations are associated with poor outcomes in multiple critical illnesses, including COVID-19. However, current methods of cell-free mitochondrial DNA quantification in plasma are time-consuming and lack repro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fefc7fffd83c44a696b0b0d3ccdf365
https://pubmed.ncbi.nlm.nih.gov/35699291

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Surfactant Activity and the Pressure-Volume Curve of the Respiratory System

Autor: Atul Malhotra, Roger G. Spragg, C. Corey Hardin

Publikováno v: Cardiopulmonary Monitoring ISBN: 9783030733865

To a significant extent, the existence of an air-liquid interface at the alveolar surface determines the macroscopic mechanical behavior of the lung. The mechanical properties of the air-liquid interface, in turn, result from the complex behavior and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5997bd03488ae1dcf511c4ef6b5e86cf
https://doi.org/10.1007/978-3-030-73387-2_17

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Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria

Autor: Jeremy R. Beitler, Robert L. Owens, Scott A. Sands, Michael A. Matthay, Stephen H. Loring, B. Taylor Thompson, Daniel Talmor, Roger G. Spragg, Atul Malhotra

Publikováno v: Beitler, JR; Sands, SA; Loring, SH; Owens, RL; Malhotra, A; Spragg, RG; et al.(2016). Quantifying unintended exposure to high tidal volumes from breath stacking dyssynchrony in ARDS: the BREATHE criteria. INTENSIVE CARE MEDICINE, 42(9), 1427-1436. doi: 10.1007/s00134-016-4423-3. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/3qv5j1tp
Intensive care medicine, vol 42, iss 9

PurposeBreath stacking dyssynchrony generates higher tidal volumes than intended, potentially increasing lung injury risk in acute respiratory distress syndrome (ARDS). Lack of validated criteria to quantify breath stacking dyssynchrony contributes t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998728d983df779e2ca25d8ed1c5eca6
http://www.escholarship.org/uc/item/3qv5j1tp

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Recombinant Surfactant Protein C–based Surfactant for Patients with Severe Direct Lung Injury

Autor: Andreas Günther, James F. Lewis, Kenneth Krell, Roger G. Spragg, Nathan C. Dean, Peter Schenk, Andreas Karabinis, Clemens Ruppert, Friedemann J.H. Taut

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 183:1055-1061

Patients with acute lung injury have impaired function of the lung surfactant system. Prior clinical trials have shown that treatment with exogenous recombinant surfactant protein C (rSP-C)-based surfactant results in improvement in blood oxygenation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59199a36b8c6fec94cc2790eb2879db0
https://doi.org/10.1164/rccm.201009-1424oc

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A Search for Subgroups of Patients With ARDS Who May Benefit From Surfactant Replacement Therapy

Autor: Andreas Günther, Roger G. Spragg, G. P. Findlay, Wilhelm Wurst, Gerd Rippin, Friedemann J.H. Taut, Peter Schenk, James F. Lewis, Dietrich Häfner, Werner Seeger

Publikováno v: Chest. 134:724-732

Background Studies to date have shown no survival benefit for the use of exogenous surfactant to treat patients with the ARDS. To identify specific patient subgroups for future study, we performed an exploratory post hoc analysis of clinical trials o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::980dad5c1f62c54050b3dcfec08df4d8
https://doi.org/10.1378/chest.08-0362

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Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials

Autor: Michael A. Matthay, Kathleen D. Liu, Hanjing Zhuo, Jeremy R. Beitler, B. Taylor Thompson, Roger G. Spragg, Daniel Talmor, Douglas Hayden, Atul Malhotra

Publikováno v: Beitler, JR; Thompson, BT; Matthay, MA; Talmor, D; Liu, KD; Zhuo, H; et al.(2015). Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Critical Care Medicine, 43(5), 1026-1035. doi: 10.1097/CCM.0000000000000921. UCSF: Retrieved from: http://www.escholarship.org/uc/item/3pv7h3h2
Critical care medicine, vol 43, iss 5

Author(s): Beitler, Jeremy R; Thompson, B Taylor; Matthay, Michael A; Talmor, Daniel; Liu, Kathleen D; Zhuo, Hanjing; Hayden, Douglas; Spragg, Roger G; Malhotra, Atul | Abstract: ObjectivesPulmonary dead-space fraction is one of few lung-specific ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfeba495b9fd59cf9e5b197ab006c5d
http://www.escholarship.org/uc/item/3pv7h3h2

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Pulmonary Surfactant-Update on Function, Molecular Biology and Clinical Implications

Autor: Ulrich Pison, Joanna Floros, David S. Phelps, Roger G. Spragg

Publikováno v: Current Respiratory Medicine Reviews. 1:77-84

This review is based on the contents of an international congress entitled, "Surfactant 2004", organized by Drs. B. Lachmann and L.M.G. van Golde and held in Berlin, Germany. This is the fourth meeting of its kind; the first one was held in 1989. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12edb0d7109a418ee6a118eed14f8f9f
https://doi.org/10.2174/1573398052953631

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Effect of Recombinant Surfactant Protein C–Based Surfactant on the Acute Respiratory Distress Syndrome

Autor: Michael C Witte, Werner Seeger, James F. Lewis, Jay A. Johannigman, Roger G. Spragg, Friedemann J.H. Taut, Pierre-François Laterre, Gerd Rippin, Hans-Dieter Walmrath, Guy A. Richards, Dietrich Häfner, Frank Rathgeb, Geoff Bellingan

Publikováno v: New England Journal of Medicine. 351:884-892

BACKGROUND: Preclinical studies suggest that exogenous surfactant may be of value in the treatment of the acute respiratory distress syndrome (ARDS), and two phase 2 clinical trials have shown a trend toward benefit. We conducted two phase 3 studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708bf7aea8f078d83cbaba2d7ad4d38
https://doi.org/10.1056/nejmoa033181

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The Future of Surfactant Therapy for Patients with Acute Lung Injury – New Requirements and New Surfactants

Autor: Roger G. Spragg

Publikováno v: Neonatology. 81:20-24

New requirements must be considered when designing trials of new lung surfactants for patients with acute lung injury (ALI). Radiographic inclusion criteria must be carefully applied if they are to generate reproducible patient groups. Strategies for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a774f525b256ef4deda9bd80bc49eb
https://doi.org/10.1159/000056767

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