Výsledky vyhledávání - "Roger F. Searle"

Quantification of spiral artery remodelling using an Adobe Photoshop-based technique

Autor: Roger F. Searle, Barbara A. Innes, Stephen C. Robson, HA Otun, Gendie E. Lash, Elizabeth Ball, B Schiessl, Judith N. Bulmer

Publikováno v: Reproduction. 158:389-397

Uterine spiral arteries undergo remodelling in normal pregnancy, with replacement of the musculoelastic arterial media by fibrinoid containing extravillous trophoblast cells. Deficient spiral artery remodelling is associated with several adverse preg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aed150e3393c4491075e5ad3aea194
https://doi.org/10.1530/rep-19-0133

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Tomorrow's Doctors: Students' Satisfaction with a Prosection-Based Undergraduate Anatomy Course

Autor: David Hamilton, D Overbeck-Zubrzycka, A Krishnan, Roger F. Searle, Gerard Stansby

Publikováno v: The Bulletin of the Royal College of Surgeons of England. 94:1-4

The undergraduate curriculum is the starting point for the doctors of the future. It should provide a strong foundation for learning and practice as a junior doctor and beyond. In the modern era, anatomy teaching, as with all other areas of the curri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24098fdeecfa399100b7e90a705be767
https://doi.org/10.1308/147363512x13189526437711

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Role of Interleukin 8 in Uterine Natural Killer Cell Regulation of Extravillous Trophoblast Cell Invasion

Autor: Stephen C. Robson, C. Murray-Dunning, Roger F. Searle, Gendie E. Lash, Nelson Sass, Barbara A. Innes, L.G. De Oliveira, Judith N. Bulmer

Publikováno v: Placenta. 31:595-601

Background Extravillous trophoblast cell (EVT) invasion of maternal tissues is critical for successful pregnancy. Decidual factors, including uterine natural killer (uNK) and T cell derived cytokines play a role in regulating this process. Interleuki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e917e1aec21a0ba9ef4799d6d0875e44
https://doi.org/10.1016/j.placenta.2010.04.012

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Effect of Low Oxygen Concentrations on Trophoblast-Like Cell Line Invasion

Autor: A. Brunt, Gendie E. Lash, Stephen C. Robson, M Kirkley, Judith N. Bulmer, Janet Hornbuckle, Roger F. Searle

Publikováno v: Placenta. 28:390-398

The applicability of trophoblast-like cell lines to the study of trophoblast function has been widely debated. The present study investigated the effect of oxygen on the invasiveness, apoptosis, proliferation and secreted proteases of four different

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d953751b1596df39d8f06254021e15
https://doi.org/10.1016/j.placenta.2006.06.001

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Interferon‐γ inhibits extravillous trophoblast cell invasion by a mechanism that involves both changes in apoptosis and protease levels

Autor: Maureen Kirkley, Roger F. Searle, Judith N. Bulmer, Stephen C. Robson, HA Otun, Barbara A. Innes, Leandro Gustavo de Oliveira, Gendie E. Lash

Publikováno v: The FASEB Journal. 20:2512-2518

Extravillous trophoblast cell (EVT) invasion of decidua and inner third of the myometrium is critical for a successful pregnancy. Many decidual factors are likely to play a role in regulating this process, including uterine natural killer (uNK) cell-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb60c499e8d6920498b9e5ae6896982
https://doi.org/10.1096/fj.06-6616com

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Effector Activity of Decidual CD8+ T Lymphocytes in Early Human Pregnancy1

Autor: Barbara A. Innes, Roger F. Searle, Paula J. Scaife, Stephen C. Robson, Judith N. Bulmer

Publikováno v: Biology of Reproduction. 75:562-567

Although CD8+ T lymphocytes are present in human decidua throughout pregnancy, albeit as a minor population in early pregnancy, their role in normal pregnancy is largely unknown. The present study aimed to characterize their effector phenotype, inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b6b587ca0b7607518eb1767fb7e67ca0
https://doi.org/10.1095/biolreprod.106.052654

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Low Oxygen Concentrations Inhibit Trophoblast Cell Invasion from Early Gestation Placental Explants via Alterations in Levels of the Urokinase Plasminogen Activator System1

Autor: Roger F. Searle, Barbara A. Innes, Gendie E. Lash, HA Otun, Judith N. Bulmer, Stephen C. Robson

Publikováno v: Biology of Reproduction. 74:403-409

Extravillous trophoblast cell (EVT) invasion in early pregnancy occurs in a relatively low-oxygen environment. The role of oxygen in regulation of EVT invasion remains controversial. We hypothesized that 1) culture in 3% oxygen inhibits EVT invasion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::278592b58b16db4c9e1d4ba1196c2a5a
https://doi.org/10.1095/biolreprod.105.047332

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Inhibition of Trophoblast Cell Invasion by TGFB1, 2, and 3 Is Associated with a Decrease in Active Proteases1

Autor: Barbara A. Innes, Judith N. Bulmer, HA Otun, Roger F. Searle, Gendie E. Lash, Stephen C. Robson

Publikováno v: Biology of Reproduction. 73:374-381

Invasion of extravillous trophoblast cells into the uterus in human pregnancy is tightly regulated. The transforming growth factor-beta (TGFB) family has been suggested to play a role in controlling this process. We hypothesized that TGFB1, 2, and 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae52a2f732f9f9410e4c672527dde126
https://doi.org/10.1095/biolreprod.105.040337

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