Výsledky vyhledávání - "Roger D. Zühlke"

Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels

Autor: Howard Schulman, Richard W. Tsien, Harald Reuter, Roger D. Zühlke, Geoffrey S. Pitt, Andy Hudmon

Publikováno v: Journal of Biological Chemistry. 276:30794-30802

Ca(2+)-dependent inactivation (CDI) of L-type Ca(2+) channels plays a critical role in controlling Ca(2+) entry and downstream signal transduction in excitable cells. Ca(2+)-insensitive forms of calmodulin (CaM) act as dominant negatives to prevent C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccbcce3c303396eb4ca52bbcd752adba
https://doi.org/10.1074/jbc.m104959200

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Ca2+-sensitive Inactivation and Facilitation of L-type Ca2+ Channels Both Depend on Specific Amino Acid Residues in a Consensus Calmodulin-binding Motif in theα1C subunit

Autor: Roger D. Zühlke, Richard W. Tsien, Geoffrey S. Pitt, Harald Reuter

Publikováno v: Journal of Biological Chemistry. 275:21121-21129

L-type Ca(2+) channels are unusual in displaying two opposing forms of autoregulatory feedback, Ca(2+)-dependent inactivation and facilitation. Previous studies suggest that both involve direct interactions between calmodulin (CaM) and a consensus Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9e35ea84f0c1f7b1384b0bcefc7574
https://doi.org/10.1074/jbc.m002986200

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Calmodulin supports both inactivation and facilitation of L-type calcium channels

Autor: Karl Deisseroth, Richard W. Tsien, Geoffrey S. Pitt, Harald Reuter, Roger D. Zühlke

Publikováno v: Nature. 399:159-162

L-type Ca2+ channels support Ca2+ entry into cells, which triggers cardiac contraction, controls hormone secretion from endocrine cells and initiates transcriptional events that support learning and memory. These channels are examples of molecular si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d7e9c5f96918dfce174e932d9cc23a54
https://doi.org/10.1038/20200

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Molecular Structures Involved in L-type Calcium Channel Inactivation

Autor: Roger D. Zühlke, Harald Reuter, Alexandre Bouron, Nikolai M. Soldatov

Publikováno v: Journal of Biological Chemistry. 272:3560-3566

The pore-forming α1C subunit is the principal component of the voltage-sensitive L-type Ca2+ channel. It has a long cytoplasmic carboxyl-terminal tail playing a critical role in channel gating. The expression of α1C subunits is characterized by alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb25774448cc858e48d3504268257c2b
https://doi.org/10.1074/jbc.272.6.3560

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Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene

Autor: Nikolai M. Soldatov, Roger D. Zühlke, Alexandre Bouron, Harald Reuter

Publikováno v: FEBS letters. 427(2)

L-type Ca2+ channels are important targets for drugs, such as dihydropyridines (DHPs), in the treatment of cardiovascular diseases. Channel expression is regulated by alternative splicing. It has been suggested that in the cardiovascular system tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219fba393fb867cb0f78fe5e8944a89f
https://pubmed.ncbi.nlm.nih.gov/9607315

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Ca2+-sensitive inactivation of L-type Ca2+ channels depends on multiple cytoplasmic amino acid sequences of the α1C subunit

Autor: Roger D. Zühlke, Harald Reuter

Ca 2+ -dependent inactivation of Ca 2+ currents is a physiological phenomenon widely associated with L-type Ca 2+ channels. Although the pore-forming α 1C subunit of the channel is the target for Ca 2+ binding, the amino acid sequences involved in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c41d266e63f08f8757f1446a5efa159
https://europepmc.org/articles/PMC19734/

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[4] Xenopus oocytes: A system for expression cloning and structure-function studies of ion channels and receptors

Autor: Roger D. Zühlke, Rolf H. Joho, Hui-Juan Zhang

Publikováno v: Methods in Neurosciences ISBN: 9780121852955

Publisher Summary This chapter discusses Xenopus oocytes, which is a system for expression cloning and structure–function studies of ion channels and receptors. The advantages of the Xenopus oocyte compared to other expression systems are severalfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5e81a527abb37ebd63c8f63fc029f1c
https://doi.org/10.1016/s1043-9471(05)80034-5

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Heterologous expression of the human potassium channel Kv2.1 in clonal mammalian cells by direct cytoplasmic microinjection of cRNA

Autor: Roger D. Zühlke, Deborah L. Lewis, Stephen R. Ikeda, Fernando Soler, Rolf H. Joho

Publikováno v: Pflugers Archiv : European journal of physiology. 422(2)

The cloned human delayed rectifying K+ channel Kv2.1 (drk1) was expressed in clonal mouse fibroblasts (L-cells) and rat basophilic leukemia cells (RBL-1) by direct cytoplasmic microinjection of complementary RNA (cRNA). Within six hours, cells microi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7e71ed1e79897077744a5312863642
https://pubmed.ncbi.nlm.nih.gov/1283219

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