Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Roger D. Tung"'
Autor:
Roger D Tung
Publikováno v:
Future Medicinal Chemistry. 8:491-494
Deuterium is gaining increased appreciation and utilization as a component of active pharmaceutical ingredients. Deuteriummodified or -deuterated compounds retain the potency and selectivity of their hydrogen analogs. However, in certain cases, the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5086525cf89042d0474146307c9d79cf
https://doi.org/10.4155/fmc-2016-0032
https://doi.org/10.4155/fmc-2016-0032
Autor:
Scott L. Harbeson, Christopher L. Brummel, Dario Doller, Julie F. Liu, Robert H. Silverman, Roger D. Tung
The use of deuterium substitution in an effort to produce kinetic isotope effects (KIEs) that favorably alter pharmacokinetics and metabolism in drug discovery has accelerated in the last decade. While the effects of deuteration remain highly experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2fbe425fc282af194b33f639572cfb
https://doi.org/10.1016/bs.armc.2017.08.010
https://doi.org/10.1016/bs.armc.2017.08.010
Autor:
Lijun Wu, Sunanda Vedananda, Roger D. Tung, Virginia Braman, Scott L. Harbeson, Changfu Cheng
Publikováno v:
Journal of Mass Spectrometry. 48:1019-1031
Atazanavir (Reyataz(®)) is an important member of the HIV protease inhibitor class. Because of the complexity of its chemical structure, metabolite identification and structural elucidation face serious challenges. So far, only seven non-conjugated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31883216dbcc782c73aa4b625b8cb731
https://doi.org/10.1002/jms.3247
https://doi.org/10.1002/jms.3247
Autor:
Lijun Wu, Roger D. Tung, Changfu Cheng, Scott L. Harbeson, Robert E. Zelle, Gary W. Bridson, Richard Gallegos
Publikováno v:
Journal of Mass Spectrometry. 48:640-650
Atazanavir (marketed as Reyataz®) is an important member of the human immunodeficiency virus protease inhibitor class. LC-UV-MSn experiments were designed to identify metabolites of atazanavir after incubations in human hepatocytes. Five major (M1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::663e7fe540ac0380e05d4780b0c1ab61
https://doi.org/10.1002/jms.3201
https://doi.org/10.1002/jms.3201
Autor:
Craig E. Masse, Adam J. Morgan, Gary W. Bridson, Vinita Uttamsingh, Roger D. Tung, Sophia Nguyen, Scott L. Harbeson
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:613-624
As part of an ongoing effort to apply the Deuterated Chemical Entity Platform (DCE Platform™) to clinically validated drugs,the synthesis of deuterated analogs of the hepatitis C virus protease inhibitor boceprevir was carried out. The devisedsynth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3865237bb64bcc428f7e9f854545df19
https://doi.org/10.1002/jlcr.1905
https://doi.org/10.1002/jlcr.1905
Autor:
Gary W. Bridson, Roger D. Tung, Richard Gallegos, Vinita Uttamsingh, David S. Wells, Changfu Cheng, Robert E. Zelle, Julie F. Liu, Philip B. Graham, Scott L. Harbeson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(1)
Selective deuterium substitution as a means of ameliorating clinically relevant pharmacokinetic drug interactions is demonstrated in this study. Carbon-deuterium bonds are more stable than corresponding carbon-hydrogen bonds. Using a precision deuter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4bf7f0aecd4e0c0159fc76ce407e69
https://pubmed.ncbi.nlm.nih.gov/25943764
https://pubmed.ncbi.nlm.nih.gov/25943764
Autor:
Tom Knapp, Victor Panchenko, Paul A. Negulescu, Ashvani K. Singh, Roger D. Tung, James A. Rader, Timothy Neuberger, Fredrick Van Goor, Kimberly Straley, Jeffrey H. Stack, Jesus E. Gonzalez, Eric R. Olson, John Joubran, Dong Cao, Mark Miller, Peter D. J. Grootenhuis, Sabine Hadida, Anna R. Hazlewood, Lewis R. Makings
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 290:L1117-L1130
Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in cftr, a gene encoding a PKA-regulated Cl−channel. The most common mutation results in a deletion of phenylalanine at position 508 (ΔF508-CFTR) that impairs protein folding, tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fbd5a9130d1b6a77b6165a012ea7fa0
https://doi.org/10.1152/ajplung.00169.2005
https://doi.org/10.1152/ajplung.00169.2005
Autor:
Robert B. Perni, Yu-Ping Luong, Scott L. Harbeson, Pravin Chaturvedi, Gurudatt Chandorkar, John A. Thomson, Susan J. Almquist, Yunyi Wei, Randal Byrn, B. Govinda Rao, Gururaj Kalkeri, Kirk Dinehart, Ann D. Kwong, William P. Taylor, Cynthia A. Gates, Roger D. Tung, Kai Lin, Chao Lin, Lawrence F. Courtney, Angela D. Heiser, Caroline Decker, Elaine Kolaczkowski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:899-909
VX-950 is a potent, selective, peptidomimetic inhibitor of the hepatitis C virus (HCV) NS3-4A serine protease, and it demonstrated excellent antiviral activity both in genotype 1b HCV replicon cells (50% inhibitory concentration [IC 50 ] = 354 nM) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8312c14c93b23f42d439bf096feffe4
https://doi.org/10.1128/aac.50.3.899-909.2006
https://doi.org/10.1128/aac.50.3.899-909.2006
Autor:
Cynthia A. Gates, John A. Thomson, Kevin M. Cottrell, Yu P. Luong, Scott L. Harbeson, Robert B. Perni, John H. Van Drie, David D. Deininger, Roger D. Tung, Shawn D. Britt, Chao Lin, Janos Pitlik, Luc J. Farmer, John J. Court, Yunyi Wei, John Maxwell, Kai Lin, Bhisetti Govinda Rao, Lawrence F. Courtney, Wayne C. Schairer
Publikováno v:
Letters in Drug Design & Discovery. 2:497-502
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d420d4ea1640c769a11c7300ffa8634
https://doi.org/10.2174/157018005774479203
https://doi.org/10.2174/157018005774479203
Autor:
Kai Lin, Joseph L. Kim, Yu-Ping Luong, Janos Pitlik, Wayne C. Schairer, Chao Lin, Roger D. Tung, Robert B. Perni, John A. Thomson, John Maxwell, Luc J. Farmer, Kevin M. Cottrell, Murcko Mark A, Lawrence F. Courtney, Cynthia A. Gates, John J. Court, John H. Van Drie, David D. Deininger, Wilson Keith P, B. Govinda Rao, Scott L. Harbeson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1939-1942
We recently described the identification of an optimized α-ketoamide warhead for our series of HCV NS3·4A inhibitors. We report herein a series of HCV protease inhibitors incorporating 3-alkyl-substituted prolines in P2. These compounds show except
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee870e2ad12957f02ea4352f74bcbb2
https://doi.org/10.1016/j.bmcl.2004.01.078
https://doi.org/10.1016/j.bmcl.2004.01.078