Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Roger D. Spealman"'
Autor:
Arnar Astradsson, Bruce G. Jenkins, Ji-Kyung Choi, Penelope J. Hallett, Michele A. Levesque, Jack S. McDowell, Anna-Liisa Brownell, Roger D. Spealman, Ole Isacson
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 3, Pp 348-351 (2009)
It has been suggested, based on rodent studies, that levodopa (l-dopa) induced dyskinesia is associated with a disrupted blood–brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2
Externí odkaz:
https://doaj.org/article/a2687b2f0be24c018642711d7c1a614e
Publikováno v:
J Pharmacol Exp Ther
Buprenorphine, a partial agonist at the μ-opioid receptor, is commonly prescribed for the management of opioid addiction. Notwithstanding buprenorphine's clinical popularity, the relationship between its effectiveness in attenuating relapse-related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3246207c20f3e673cbf8b668d64d1
https://pubmed.ncbi.nlm.nih.gov/31413139
https://pubmed.ncbi.nlm.nih.gov/31413139
Autor:
Bríd Á. Nic Dhonnchadha, Kathleen M. Kantak, Roger D. Spealman, Heng-Ye Man, Amy Lin, Jamie M. Gauthier
Publikováno v:
Addiction Biology. 22:152-162
This study investigated the combination of environmental enrichment (EE) with cocaine-cue extinction training on reacquisition of cocaine self-administration. Rats were trained under a second-order schedule for which responses were maintained by coca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f448d07b246601c1ab0afb143a1033c6
https://doi.org/10.1111/adb.12313
https://doi.org/10.1111/adb.12313
Publikováno v:
Psychopharmacology. 232:2959-2968
5-Hydroxytryptamine (5-HT) transport inhibitors can attenuate the abuse-related effects of cocaine, and the mechanisms underlying this attenuation may involve activation of 5-HT2C receptors.The objective of this study was to investigate the consequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9228e72692c85af5c996053d2cbe7c
https://doi.org/10.1007/s00213-015-3932-z
https://doi.org/10.1007/s00213-015-3932-z
Autor:
Eduardo Perez-Torres, James M. Schumacher, Teresia Osborn, Maria Sundberg, Michele A. Moore, Anna-Liisa Brownell, Arnar Astradsson, Ole Isacson, Oliver Cooper, Michela Deleidi, Penelope J. Hallett, Roger D. Spealman, Gaynor A. Smith
Publikováno v:
Cell Stem Cell. 16(3):269-274
SummaryAutologous transplantation of patient-specific induced pluripotent stem cell (iPSC)-derived neurons is a potential clinical approach for treatment of neurological disease. Preclinical demonstration of long-term efficacy, feasibility, and safet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013a0bef50c6d41208e3ba60e045ec0c
Autor:
Joseph G. Wettstein, Bríd Á. Nic Dhonnchadha, Daniela Alberati, Roger D. Spealman, Emmanuel Pinard, Kathleen M. Kantak
Publikováno v:
Drug and Alcohol Dependence. 122:119-126
Combining extinction training with cognitive-enhancing pharmacotherapy represents a novel strategy for improving the efficacy of exposure therapy for drug relapse prevention. We investigated if the selective glycine transporter-1 (GlyT-1) inhibitor R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2542053170302c08751d7748e6301fa
https://doi.org/10.1016/j.drugalcdep.2011.09.017
https://doi.org/10.1016/j.drugalcdep.2011.09.017
Publikováno v:
Journal of Neurochemistry. 115:1643-1654
Amphetamine can improve cognition in healthy subjects and patients with schizophrenia, attention-deficit hyperactivity disorder, and other neuropsychiatric diseases; higher doses, however, can impair cognitive function, especially those mediated by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236cf6082ca8bef992b125a4d38bd7bb
https://doi.org/10.1111/j.1471-4159.2010.07073.x
https://doi.org/10.1111/j.1471-4159.2010.07073.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 332:985-995
Many polydrug abusers combine cocaine with heroin in the form of a "speedball." This study investigated the discriminative stimulus (DS) effects of speedballs in rhesus monkeys trained to discriminate either intravenous cocaine or intravenous heroin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c168f1427ccd5fd246cd49e84e14839
https://doi.org/10.1124/jpet.109.162941
https://doi.org/10.1124/jpet.109.162941
Publikováno v:
Psychopharmacology. 210:169-177
Kappa agonists can attenuate reinstatement of cocaine-seeking behavior induced by cocaine priming. The mechanisms underlying this effect have not been characterized fully but may have a serotonergic component as kappa agonists also increase the relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a62a3155208e609c031fdf927cd7602
https://doi.org/10.1007/s00213-009-1705-2
https://doi.org/10.1007/s00213-009-1705-2
Autor:
Donna M. Platt, Cindy Achat-Mendes, Kathleen M. Kantak, Bríd Á. Nic Dhonnchadha, Roger D. Spealman, Jonathan J. Szalay, Michael Otto
Publikováno v:
Neuropsychopharmacology. 35:357-367
Augmentation of cue exposure (extinction) therapy with cognitive-enhancing pharmacotherapy may offer an effective strategy to combat cocaine relapse. To investigate this possibility at the preclinical level, rats and squirrel monkeys were trained to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcf5a8f419d14941832a67dcb135f41
https://doi.org/10.1038/npp.2009.139
https://doi.org/10.1038/npp.2009.139