Zobrazeno 1 - 10 of 195 pro vyhledávání: '"Roger Chung"'
1
Akademický článek
Cyclin F can alter the turnover of TDP-43
Autor: Stephanie L. Rayner, Alison Hogan, Jennilee M. Davidson, Tyler Chapman, Flora Cheng, Luan Luu, Sharlynn Wu, Selina Zhang, Shu Yang, Ian Blair, Marco Morsch, Roger Chung, Albert Lee
Publikováno v: Neurobiology of Disease, Vol 192, Iss , Pp 106421- (2024)
Previously, we demonstrated that the SCFcyclin F complex directly mediates the poly-ubiquitylation of TDP-43, raising the question of whether cyclin F can be used to enhance the turnover of TDP-43. A hurdle to the use of cyclin F, however, is that th
Externí odkaz: https://doaj.org/article/938a323b072b422dbb397509b51afada
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4
Akademický článek
TDP-43 is a ubiquitylation substrate of the SCFcyclin F complex
Autor: Stephanie L. Rayner, Shu Yang, Natalie E. Farrawell, Cyril J. Jagaraj, Flora Cheng, Jennilee M. Davidson, Luan Luu, Alberto G. Redondo, Alberto Rábano, Daniel Borrego-Hernández, Julie D. Atkin, Marco Morsch, Ian P. Blair, Justin J. Yerbury, Roger Chung, Albert Lee
Publikováno v: Neurobiology of Disease, Vol 167, Iss , Pp 105673- (2022)
Background: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by the loss of upper and lower motor neurons in the brain and spinal cord. ALS and frontotemporal dementia (FTD) are overlapping diseases with shared p
Externí odkaz: https://doaj.org/article/8b0375252ae3453588b0ea1234e98d29
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6
Akademický článek
Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin
Autor: Vivek Gupta, Mehdi Mirzaei, Veer Bala Gupta, Nitin Chitranshi, Yogita Dheer, Roshana Vander Wall, Mojdeh Abbasi, Yuyi You, Roger Chung, Stuart Graham
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Neuroserpin is a serine protease inhibitor that regulates the activity of plasmin and its activators in the neuronal tissues. This study provides novel evidence of regulatory effect of the neuroserpin on plasmin proteolytic activity in the r
Externí odkaz: https://doaj.org/article/e9b70b9ed1e54766a0cc9a682a0c7d4e
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7
Akademický článek
Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease
Autor: Kathryn Goozee, Pratishtha Chatterjee, Ian James, Kaikai Shen, Hamid R. Sohrabi, Prita R. Asih, Preeti Dave, Bethany Ball, Candice ManYan, Kevin Taddei, Roger Chung, Manohar L. Garg, Ralph N. Martins
Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Brain and blood fatty acids (FA) are altered in Alzheimer’s disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current st
Externí odkaz: https://doaj.org/article/5fb81ae1caec4113ad4d2005ed84ba84
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8
Aspect Ratio of PEGylated Upconversion Nanocrystals Affects the Cellular Uptake In Vitro and In Vivo
Autor: Libing Fu, Bingyang Shi, Shihui Wen, Marco Morsch, Guoying Wang, Zhiguang Zhou, Chao Mi, Mohammad Sadraeian, Gungun Lin, Yiqing Lu, Dayong Jin, Roger Chung
Publikováno v: Acta Biomaterialia. 147:403-413
The central nervous system (CNS) is protected by the blood-brain barrier (BBB), which acts as a physical barrier to regulate and prevent the uptake of endogenous metabolites and xenobiotics. However, the BBB prevents most non-lipophilic drugs from re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b42fbe2b6c7f82d2391c1ad8520d2be
https://doi.org/10.1016/j.actbio.2022.05.029
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