Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Roger Cachope"'
Autor:
Tamara Vasilkovska, Marlies Verschuuren, Dorian Pustina, Monica vanden Berg, Johan Van Audekerke, Isabel Pintelon, Roger Cachope, Winnok H. De Vos, Annemie Van der Linden, Mohit H. Adhikari, Marleen Verhoye
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 10, Pp n/a-n/a (2024)
Abstract Background Huntington's disease (HD) is marked by irreversible loss of neuronal function for which currently no availability for disease‐modifying treatment exists. Advances in the understanding of disease progression can aid biomarker dev
Externí odkaz:
https://doaj.org/article/a1e253df09ce4de680b11b9b36934d56
Autor:
Tamara Vasilkovska, Somaie Salajeghe, Verdi Vanreusel, Johan Van Audekerke, Marlies Verschuuren, Lydiane Hirschler, Jan Warnking, Isabel Pintelon, Dorian Pustina, Roger Cachope, Ladislav Mrzljak, Ignacio Muñoz-Sanjuan, Emmanuel L. Barbier, Winnok H. De Vos, Annemie Van der Linden, Marleen Verhoye
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-16 (2024)
Abstract Background Huntington’s disease (HD) is marked by a CAG-repeat expansion in the huntingtin gene that causes neuronal dysfunction and loss, affecting mainly the striatum and the cortex. Alterations in the neurovascular coupling system have
Externí odkaz:
https://doaj.org/article/dd615e2f7fa549b7ab357d5b25a4d85d
Autor:
Nicholas Vidas-Guscic, Joëlle van Rijswijk, Johan Van Audekerke, Ben Jeurissen, Israel Nnah, Haiying Tang, Ignacio Muñoz-Sanjuan, Dorian Pustina, Roger Cachope, Annemie Van der Linden, Daniele Bertoglio, Marleen Verhoye
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106438- (2024)
Huntington's disease (HD) is a progressive neurodegenerative disease affecting motor and cognitive abilities. Multiple studies have found white matter anomalies in HD-affected humans and animal models of HD. The identification of sensitive white-matt
Externí odkaz:
https://doaj.org/article/69ee93a4208c492d9656a48bc1a39c4d
Autor:
Mohit H. Adhikari, Tamara Vasilkovska, Roger Cachope, Haiying Tang, Longbin Liu, Georgios A. Keliris, Ignacio Munoz-Sanjuan, Dorian Pustina, Annemie Van der Linden, Marleen Verhoye
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by expanded (≥ 40) glutamine-encoding CAG repeats in the huntingtin gene, which leads to dysfunction and death of predominantly striatal and cortical neurons. While the gen
Externí odkaz:
https://doaj.org/article/35a3c24ce24144dab776a39042ce305a
Autor:
Tamara Vasilkovska, Mohit H. Adhikari, Johan Van Audekerke, Somaie Salajeghe, Dorian Pustina, Roger Cachope, Haiying Tang, Longbin Liu, Ignacio Muñoz-Sanjuán, Annemie Van der Linden, Marleen Verhoye
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106095- (2023)
Huntington's disease is an autosomal, dominantly inherited neurodegenerative disease caused by an expansion of the CAG repeats in exon 1 of the huntingtin gene. Neuronal degeneration and dysfunction that precedes regional atrophy result in the impair
Externí odkaz:
https://doaj.org/article/719aee6d012d44c6b6c1cda84b72d466
Autor:
Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A. Mejias-Aponte, Jorge A. Gomez, Gabriel E. Mateo-Semidey, Gerard M.J. Beaudoin, Carlos A. Paladini, Joseph F. Cheer, Marisela Morales
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1128-1142.e7 (2019)
Summary: Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area (VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both asymmetric and symmetric synapses on VTA dopamine neurons, but most of t
Externí odkaz:
https://doaj.org/article/defa00d29ee64dc08e3795bccabda37c
Autor:
Tuukka O. Piiponniemi, Teija Parkkari, Taneli Heikkinen, Jukka Puoliväli, Larry C. Park, Roger Cachope, Maksym V. Kopanitsa
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington’s disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder. Therefore, application of max
Externí odkaz:
https://doaj.org/article/d214211a342943adb309c47625f378d5
Autor:
Roger Cachope, Yolanda Mateo, Brian N. Mathur, James Irving, Hui-Ling Wang, Marisela Morales, David M. Lovinger, Joseph F. Cheer
Publikováno v:
Cell Reports, Vol 2, Iss 1, Pp 33-41 (2012)
Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors, and its release dynamics have traditionally been linked to changes in midbrain dopamine neuron activity. Here, we report that selective endogenous cholinergic a
Externí odkaz:
https://doaj.org/article/198238d49aa547f6bbcd69334b4acd23
Autor:
Mohit H. Adhikari, Tamara Vasilkovska, Roger Cachope, Haiying Tang, Longbin Liu, Georgios A. Keliris, Ignacio Munoz-Sanjuan, Dorian Pustina, Annemie Van der Linden, Marleen Verhoye
Huntington’s disease (HD) is a neurodegenerative disorder caused by expanded (≥ 40) glutamine-encoding CAG repeats in the huntingtin gene, which leads to dysfunction and death of predominantly striatal and cortical neurons. While the genetic prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b308cc9130321d842d9570cbd08fe7d
https://doi.org/10.1101/2022.10.09.511485
https://doi.org/10.1101/2022.10.09.511485
Autor:
Tammy Ladduwahetty, Matthew R. Lee, Michel C. Maillard, Roger Cachope, Daniel Todd, Michael Barnes, Vahri Beaumont, Alka Chauhan, Caroline Gallati, Alan F. Haughan, Georg Kempf, Christopher A. Luckhurst, Kim Matthews, George McAllister, Philip Mitchell, Hiral Patel, Mark Rose, Elizabeth Saville-Stones, Stefan Steinbacher, Andrew J. Stott, Emma Thatcher, Jason Tierney, Liudvikas Urbonas, Ignacio Munoz-Sanjuan, Celia Dominguez
Publikováno v:
Journal of medicinal chemistry. 65(14)
The Rho kinase (ROCK) pathway is implicated in the pathogenesis of several conditions, including neurological diseases. In Huntington's disease (HD), ROCK is implicated in mutant huntingtin (HTT) aggregation and neurotoxicity, and members of the ROCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828c256846fb4f8cb363fd87248c71f6
https://pubmed.ncbi.nlm.nih.gov/35816678
https://pubmed.ncbi.nlm.nih.gov/35816678