Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Roger C. Whitehead"'
Autor:
Megan A. Eadsforth, Linghan Kong, George Whitehead, Iñigo J. Vitórica-Yrezábal, Raymond T. O'Keefe, Richard A. Bryce, Roger C. Whitehead
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 80, Iss 8, Pp 857-862 (2024)
The X-ray crystal structure data of 12-α-fluoro-3β-hydroxyolean-28,13β-olide methanol hemisolvate, 2C30H47FO3·CH3OH, (1), and 12-α-fluoro-3β-hydroxytaraxer-28,14β-olide methanol hemisolvate, 2C30H47FO3·CH3OH, (2), are described. The fluorolac
Externí odkaz:
https://doaj.org/article/d55563e07688471a886ae4307909b127
Autor:
Vanessa Harawa, Thomas W. Thorpe, James R. Marshall, Jack J. Sangster, Amelia K. Gilio, Lucian Pirvu, Rachel S. Heath, Antonio Angelastro, James D. Finnigan, Simon J. Charnock, Jordan W. Nafie, Gideon Grogan, Roger C. Whitehead, Nicholas J. Turner
Publikováno v:
Journal of the American Chemical Society. 144:21088-21095
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally
Autor:
Simon J. Charnock, James Finnigan, Gideon Grogan, Vanessa Harawa, Roger C. Whitehead, Amelia Kay Gilio, Antonio Angelastro, James R. Marshall, Rachel S. Heath, Thomas W. Thorpe, Nicholas J. Turner
The development of efficient and sustainable methods for the synthesis of nitrogen heterocycles is an important goal for the chemical industry. In particular, substituted chiral piperidines are prominent targets due to their prevalence in medicinally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86904dd65faa4487bcbb9ff11d6f754
https://doi.org/10.33774/chemrxiv-2021-bdgqd
https://doi.org/10.33774/chemrxiv-2021-bdgqd
Autor:
Gregory Koningstein, Adolfo Cavalié, Julia Oswald, Joen Luirink, Maurice Steenhuis, Tillman Pick, Roger C. Whitehead, Sarah O'Keefe, Eileithyia Swanton, Hans-Georg Koch, Stephen High
Publikováno v:
Molecular Microbiology, 115(1):32798330, 28-40. Wiley-Blackwell
Molecular Microbiology
Steenhuis, M, Koningstein, G M, Oswald, J, Pick, T, O’Keefe, S, Koch, H G, Cavalié, A, Whitehead, R C, Swanton, E, High, S & Luirink, J 2021, ' Eeyarestatin 24 impairs SecYEG-dependent protein trafficking and inhibits growth of clinically relevant pathogens ', Molecular Microbiology, vol. 115, no. 1, 32798330, pp. 28-40 . https://doi.org/10.1111/mmi.14589
Steenhuis, M, Koningstein, G M, Oswald, J, Pick, T, O'Keefe, S, Koch, H-G, Cavalie, A, Whitehead, R, Swanton, E, High, S & Luirink, J 2020, ' Eeyarestatin 24 Impairs SecYEG-dependent Protein Trafficking and Inhibits Growth of Clinically Relevant Pathogens ', Molecular Microbiology . https://doi.org/10.1111/mmi.14589
Molecular Microbiology
Steenhuis, M, Koningstein, G M, Oswald, J, Pick, T, O’Keefe, S, Koch, H G, Cavalié, A, Whitehead, R C, Swanton, E, High, S & Luirink, J 2021, ' Eeyarestatin 24 impairs SecYEG-dependent protein trafficking and inhibits growth of clinically relevant pathogens ', Molecular Microbiology, vol. 115, no. 1, 32798330, pp. 28-40 . https://doi.org/10.1111/mmi.14589
Steenhuis, M, Koningstein, G M, Oswald, J, Pick, T, O'Keefe, S, Koch, H-G, Cavalie, A, Whitehead, R, Swanton, E, High, S & Luirink, J 2020, ' Eeyarestatin 24 Impairs SecYEG-dependent Protein Trafficking and Inhibits Growth of Clinically Relevant Pathogens ', Molecular Microbiology . https://doi.org/10.1111/mmi.14589
Eeyarestatin 1 (ES1) is an inhibitor of endoplasmic reticulum (ER) associated protein degradation, Sec61‐dependent Ca2+ homeostasis and protein translocation into the ER. Recently, evidence was presented showing that a smaller analog of ES1, ES24,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf86b09944bd43755fd331784f1f6d7
https://research.vu.nl/en/publications/990f177a-afcd-4c8a-aaf0-8a5809e2d955
https://research.vu.nl/en/publications/990f177a-afcd-4c8a-aaf0-8a5809e2d955
Autor:
Karen A. Nolan, Hoda Abdel-Aal Bettley, M. Clare Caraher, Thomas A. Jowitt, Ian J. Stratford, Katherine A. Scott, David J. Timson, Clare F. Megarity, Aldo Gutierrez, Roger C. Whitehead, Richard A. Bryce
Publikováno v:
Megarity, C F, Abdel-Aal Bettley, H, Caraher, M C, Scott, K A, Whitehead, R C, Jowitt, T A, Gutierrez, A, Bryce, R A, Nolan, K A, Stratford, I J & Timson, D J 2019, ' Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1) ', CHEMBIOCHEM, vol. 20, no. 22, pp. 2841-2849 . https://doi.org/10.1002/cbic.201900313
NAD(P)H quinone oxidoreductase-1 (NQO1) is a homodimeric protein that acts as a detoxifying enzyme or as a chaperone protein. Dicourmarol interacts with NQO1 at the NAD(P)H binding site and can both inhibit enzyme activity and modulate the interactio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a75211354ea9abe34071dc859c22ca9
https://www.research.manchester.ac.uk/portal/en/publications/negative-cooperativity-in-nadph-quinone-oxidoreductase-1-nqo1(b19365fc-677f-4182-bbe6-16aac8fb102b).html
https://www.research.manchester.ac.uk/portal/en/publications/negative-cooperativity-in-nadph-quinone-oxidoreductase-1-nqo1(b19365fc-677f-4182-bbe6-16aac8fb102b).html
Autor:
Timofey, Skvortsov, Patrick, Hoering, Ksenia, Arkhipova, Roger C, Whitehead, Derek R, Boyd, Christopher C R, Allen
Publikováno v:
Genome Announcements
Here, we present draft genome sequences of Pseudomonas putida strains UV4 and UV4/95, which demonstrate an ability to conduct a wide range of industrially important biotransformations of arenes, alkenes, and phenols.
Autor:
Christopher C. R. Allen, Patrick Hoering, Roger C. Whitehead, Timofey Skvortsov, Derek R. Boyd, Ksenia Arkhipova
Publikováno v:
Skvortsov, T, Hoering, P, Arkhipova, K, Whitehead, R C, Boyd, D R & Allen, C C R 2018, ' Draft genome sequences of Pseudomonas putida UV4 and UV4/95, toluene dioxygenaseexpressing producers of cis-1,2-dihydrodiols ', Genome Announcements, vol. 6, no. 1, e01419-17, pp. 1-2 . https://doi.org/10.1128/genomeA.01419-17
Skvortsov, T, Hoering, P, Arkhipova, K, Whitehead, R, Boyd, D R & Allen, C C R 2018, ' Draft Genome Sequences of Pseudomonas putida UV4 and UV4/95, Toluene Dioxygenase-Expressing Producers of cis-1,2-Dihydrodiols ', Genome Announcements, vol. 4, no. 1, e01419-17 . https://doi.org/10.1128/genomeA.01419-17
Skvortsov, T, Hoering, P, Arkhipova, K, Whitehead, R, Boyd, D R & Allen, C C R 2018, ' Draft Genome Sequences of Pseudomonas putida UV4 and UV4/95, Toluene Dioxygenase-Expressing Producers of cis-1,2-Dihydrodiols ', Genome Announcements, vol. 4, no. 1, e01419-17 . https://doi.org/10.1128/genomeA.01419-17
Here, we present draft genome sequences of Pseudomonas putida strains UV4 and UV4/95, which demonstrate an ability to conduct a wide range of industrially important biotransformations of arenes, alkenes, and phenols.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5e762ab771dfaa7673462a972134e9
https://pure.qub.ac.uk/en/publications/draft-genome-sequences-of-pseudomonas-putida-uv4-and-uv495-toluene-dioxygenaseexpressing-producers-of-cis12dihydrodiols(934c289e-874e-46a1-92ee-927302a71b73).html
https://pure.qub.ac.uk/en/publications/draft-genome-sequences-of-pseudomonas-putida-uv4-and-uv495-toluene-dioxygenaseexpressing-producers-of-cis12dihydrodiols(934c289e-874e-46a1-92ee-927302a71b73).html
Autor:
Robin G. Pritchard, Laurence M. Harwood, Alyn C. Edwards, Udo Müllich, Roger C. Whitehead, Clint A. Sharrad, Andreas Geist
Publikováno v:
Edwards, A, Geist, A, Müllich, U, Sharrad, C, Pritchard, R, Whitehead, R & Harwood, L M 2017, ' Transition Metal-Free, Visible-Light Mediated Synthesis of 1,10-Phenanthroline Derived Ligand Systems ', Chemical Communications-Royal Society of Chemistry, vol. 53, pp. 8160-8163 . https://doi.org/10.1039/C7CC03903D
A broad range of 1,10-phenanthroline substrates was efficiently C–H functionalised, providing rapid, gram-scale access to substituted heteroaromatic cores of broad utility. Furthermore, this C–H functionalisation pathway was extended to the synth
Autor:
Andreas Geist, Clint A. Sharrad, Alyn C. Edwards, Melissa A. Denecke, Roger C. Whitehead, Pavle Mocilac, Laurence M. Harwood, Neil A. Burton
Publikováno v:
Edwards, A, Mocilac, P, Geist, A, Harwood, L M, Sharrad, C, Burton, N, Whitehead, R & Denecke, M A 2017, ' Hydrophilic 2,9-bis-triazolyl-1,10-phenanthroline ligands enable selective Am(III) separation: a step further towards sustainable nuclear energy ', Chemical Communications, vol. 53, pp. 5001-5004 . https://doi.org/10.1039/C7CC01855J
The first hydrophilic, 1,10-phenanthroline derived ligands consisting of only C, H, O and N atoms for the selective extraction of Am(iii) from spent nuclear fuel are reported herein. One of these 2,9-bis-triazolyl-1,10-phenanthroline (BTrzPhen) ligan
Autor:
Stephania Christou, Alyn C. Edwards, Ian J. Stratford, Robin G. Pritchard, Roger C. Whitehead, Peter Quayle
Publikováno v:
Synlett. 25:1263-1266
The unexpected discovery of an eliminative deprotection and cyclodimerization cascade reaction sequence led to the preparation of a series of perhydrodibenzofuranones that bear a structural resemblance to the natural product incarviditone. One of the