Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Roger C, Wiggins"'
Autor:
Abhijit S. Naik, Su Q. Wang, Mahboob Chowdhury, Jawad Aqeel, Christopher L. O’Connor, Jocelyn E. Wiggins, Markus Bitzer, Roger C. Wiggins
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Increasing evidence suggests that single in kidney states (e.g., kidney transplantation and living donation) progressive glomerulosclerosis limits kidney lifespan. Modeling shows that post-nephrectomy compensatory glomerular volume (GV) incr
Externí odkaz:
https://doaj.org/article/64cee3c1b04e483891ea2275a2fe847c
Autor:
Markus Bitzer, Wenjun Ju, Lalita Subramanian, Jonathan P. Troost, Joseph Tychewicz, Becky Steck, Roger C. Wiggins, Debbie S. Gipson, Crystal A. Gadegbeku, Frank C. Brosius, Matthias Kretzler, Subramaniam Pennathur
Publikováno v:
American Journal of Physiology-Renal Physiology. 323:F401-F410
Research on kidney diseases is being transformed by the rapid expansion and innovations in omics technologies. The analysis, integration, and interpretation of big data, however, have been an impediment to the growing interest in applying these techn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ca435a66e6bcf076b69f40c3cea9fa
https://doi.org/10.1152/ajprenal.00091.2022
https://doi.org/10.1152/ajprenal.00091.2022
Autor:
Roger C. Wiggins, Christopher L. O’Connor, Jennifer A. Schaub, Jian Shi, Kerby Shedden, Markus Bitzer, Jeffrey B. Hodgin
Publikováno v:
J Clin Pathol
AimsDetection of one segmentally sclerosed glomerulus (SSG) identifies patients with focal segmental glomerulosclerosis (FSGS) but rare SSGs may be missed in kidney biopsies. It is unknown whether alterations of unaffected glomeruli in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f574902166b94a858c3601fc1cfba0c5
https://doi.org/10.1136/jclinpath-2020-207149
https://doi.org/10.1136/jclinpath-2020-207149
Autor:
Larysa Wickman, Jeffrey B Hodgin, Su Q Wang, Farsad Afshinnia, David Kershaw, Roger C Wiggins
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155255 (2016)
The proximate genetic cause of both Thin GBM and Alport Syndrome (AS) is abnormal α3, 4 and 5 collagen IV chains resulting in abnormal glomerular basement membrane (GBM) structure/function. We previously reported that podocyte detachment rate measur
Externí odkaz:
https://doaj.org/article/f541cf8e5ee6451c8bd6615ecc9c2eb4
Autor:
Rajasree Menon, Edgar A. Otto, Celine C. Berthier, Viji Nair, Evan A. Farkash, Jeffrey B. Hodgin, Yingbao Yang, Jinghui Luo, Kenneth J. Woodside, Haniyeh Zamani, Silas P. Norman, Roger C. Wiggins, Matthias Kretzler, Abhijit S. Naik
Publikováno v:
Kidney Int
Increased podocyte detachment begins immediately after kidney transplantation and is associated with long-term allograft failure. We hypothesized that cell-specific transcriptional changes in podocytes and glomerular endothelial cells after transplan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140b6a11b5dcd444d173855af1a99836
https://europepmc.org/articles/PMC9067613/
https://europepmc.org/articles/PMC9067613/
Publikováno v:
Clin Transplant
Long-term kidney transplant (KT) survival has remained relatively stagnant. Protocol biopsy studies suggest that glomerulosclerosis is a significant contributor to long-term graft failure. We previously demonstrated that podocyte loss in the 1st year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8107c391e2bb392a26f7ac87705e9cc
https://doi.org/10.1111/ctr.14457
https://doi.org/10.1111/ctr.14457
Autor:
Masao Kikuchi, Yuji Sato, Roger C. Wiggins, Kazuo Kitamura, Akihiro Minakawa, Shouichi Fujimoto, Akihiro Fukuda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Type2 diabetes-associated nephropathy is the commonest cause of renal failure. Mechanisms responsible are controversial. Leptin-deficient hyperphagic Zucker (fa/fa) rats were modeled to test the hypothesis that glomerular enlargement drives podocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4c10375e2bd2cdf05aa3ad6436e68f
http://link.springer.com/article/10.1038/s41598-019-54692-z
http://link.springer.com/article/10.1038/s41598-019-54692-z
Autor:
Jawad Aqeel, Abhijit S. Naik, Su Q. Wang, Mahboob Chowdhury, Roger C. Wiggins, Christopher L. O’Connor, Jocelyn Wiggins, Markus Bitzer
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Increasing evidence suggests that single in kidney states (e.g., kidney transplantation and living donation) progressive glomerulosclerosis limits kidney lifespan. Modeling shows that post-nephrectomy compensatory glomerular volume (GV) increase driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025dde63c74f882455704995328d9fa5
https://pubmed.ncbi.nlm.nih.gov/34599260
https://pubmed.ncbi.nlm.nih.gov/34599260
Autor:
Yuji Sato, Akihiro Fukuda, Abhijit S. Naik, Akihiro Minakawa, Tetsu Mizoguchi, Shuji Nakamura, Shouichi Fujimoto, Hirotaka Shibata, Roger C. Wiggins, Masao Kikuchi, Masanao Nagatomo, Naoya Fukunaga
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Earlier detection of progression risk in diabetic nephropathy will allow earlier intervention to reduce progression. The hypothesis that urinary pellet podocyte mRNA is a more sensitive progression risk marker than microalbuminuria was tested. A cros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab4402b0833a0af673bd22c2e40b91e
https://pubmed.ncbi.nlm.nih.gov/33097787
https://pubmed.ncbi.nlm.nih.gov/33097787
Autor:
Edgar A. Otto, Santhi K. Ganesh, Roger C. Wiggins, Alan V. Smrcka, Douglas K. Atchison, Christopher L. O’Connor, Markus Bitzer, Rajasree Menon
Publikováno v:
Am J Physiol Renal Physiol
Loss-of-function mutations in phospholipase C-ε1 (PLCE1) have been detected in patients with nephrotic syndrome, but other family members with the same mutation were asymptomatic, suggesting additional stressor are required to cause the full phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd48c4ec99daa384e68913ac542de66
https://europepmc.org/articles/PMC7294338/
https://europepmc.org/articles/PMC7294338/