Brain reserve and physical disability in secondary progressive multiple sclerosis

Autor: Nevin John, Jeremy Chataway, Jacqueline Palace, Gavin Giovannoni, David Paling, Frederik Barkhof, Floriana De Angelis, Lorraine Smith, Thomas Williams, Martin Duddy, James Overell, Basil Sharrack, Sebastien Ourselin, Allan Walker, Siddharthan Chandran, Richard Nicholas, Shuna Colville, Peter Connick, Carolyn Young, Jeremy Hobart, Anisha Doshi, Sharmilee Gnanapavan, Helen Ford, Baljean Dhillon, Thanh Phan, Arman Eshaghi, Julia Aram, Nigel Stallard, James Cameron, Brendan McLean, Matthew Craner, Domenico Plantone, Jonathan Stutters, Ferran Prados Carrasco, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Clive Hawkins, Roger Bastow, Daisy Mollison, Waqar Rashid, Joe Guadagno, Nikolaos Evangelou, Seema Kalra, Alberto Calvi, Yingtong Li, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, Heinke Arndt

Publikováno v: BMJ Neurology Open, Vol 6, Iss 2 (2024)

Background The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain reserve, has been associated with reduced p

Externí odkaz: https://doaj.org/article/03779c5cc9264a67966bb74f4a5ef24d

Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

Autor: Jeremy Chataway, Floriana De Angelis, Peter Connick, Richard A Parker, Domenico Plantone, Anisha Doshi, Nevin John, Jonathan Stutters, David MacManus, Ferran Prados Carrasco, Frederik Barkhof, Sebastien Ourselin, Marie Braisher, Moira Ross, Gina Cranswick, Sue H Pavitt, Gavin Giovannoni, Claudia Angela Gandini Wheeler-Kingshott, Clive Hawkins, Basil Sharrack, Roger Bastow, Christopher J Weir, Nigel Stallard, Siddharthan Chandran, Claudia A.M. Gandini Wheeler-Kingshott, Thomas Williams, Tiggy Beyene, Vanessa Bassan, Alvin Zapata, Dawn Lyle, James Cameron, Daisy Mollison, Shuna Colville, Baljean Dhillon, Christopher J. Weir, Richard A. Parker, Sharmilee Gnanapavan, Richard Nicholas, Waqar Rashid, Julia Aram, Helen Ford, James Overell, Carolyn Young, Heinke Arndt, Martin Duddy, Joe Guadagno, Nikolaos Evangelou, Matthew Craner, Jacqueline Palace, Jeremy Hobart, David Paling, Seema Kalra, Brendan McLean

Publikováno v: Chataway, J, De Angelis, F, Connick, P, Parker, R A, Plantone, D, Doshi, A, John, N, Stutters, J, Macmanus, D, Prados Carrasco, F, Barkhof, F, Ourselin, S, Braisher, M, Ross, M, Cranswick, G, Pavitt, S H, Giovannoni, G, Gandini Wheeler-kingshott, C A, Hawkins, C, Sharrack, B, Bastow, R, Weir, C J & Stallard, N & Chandran, S 2020, ' Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART) : a phase 2b, multiarm, double-blind, randomised placebo-controlled trial ', The Lancet Neurology, vol. 19, no. 3, pp. 214-225 . https://doi.org/10.1016/S1474-4422(19)30485-5
O2, repositorio institucional de la UOC
Universitat Oberta de Catalunya (UOC)
Chataway, J, De Angelis, F, Connick, P, Parker, R A, Plantone, D, Doshi, A, John, N, Stutters, J, MacManus, D, Prados Carrasco, F, Barkhof, F, Ourselin, S, Braisher, M, Ross, M, Cranswick, G, Pavitt, S H, Giovannoni, G, Gandini Wheeler-Kingshott, C A, Hawkins, C, Sharrack, B, Bastow, R, Weir, C J, Stallard, N, Chandran, S & MS-SMART Investigators 2020, ' Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART) : a phase 2b, multiarm, double-blind, randomised placebo-controlled trial ', The Lancet Neurology, vol. 19, no. 3, pp. 214-225 . https://doi.org/10.1016/S1474-4422(19)30485-5
The Lancet Neurology, 19(3), 214-225. Lancet Publishing Group

Background:\ud Neurodegeneration is the pathological substrate that causes major disability in secondary progressive multiple sclerosis. A synthesis of preclinical and clinical research identified three neuroprotective drugs acting on different axona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f581bddcf3bd1c8dee8246962ef8a8
https://doi.org/10.1016/s1474-4422(19)30485-5

Concept for a vertical maintenance remote handling system for multi module blanket segments in DEMO

Autor: N. Sykes, D. Iglesias, Jon Harman, A. Loving, Roger Bastow, David Cooper, M. Coleman

Publikováno v: Fusion Engineering and Design. 89:2347-2351

The anticipated high neutron flux, and the consequent damage to plasma-facing components in DEMO, results in the need to regularly replace the tritium breeding and radiation shielding blanket. The current European multi module segment (MMS) blanket c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0786207c92cfd54bf31b098533b8efea
https://doi.org/10.1016/j.fusengdes.2014.02.047

Remote handling assessment of attachment concepts for DEMO blanket segments

Autor: Oliver Crofts, Romain Sibois, Robert Crowe, D. Iglesias, A. Loving, Dave Cooper, Dave Middleton-Gear, Z. Vizvary, Roger Bastow, Jon Harman, D. Carloni

Publikováno v: Iglesias, D, Bastow, R, Cooper, D, Crowe, R, Middleton-Gear, D, Sibois, R, Carloni, D, Vizvary, Z, Crofts, O, Harman, J & Loving, A 2015, ' Remote handling assessment of attachment concepts for DEMO blanket segments ', Fusion Engineering and Design, vol. 98-99, pp. 1500-1504 . https://doi.org/10.1016/j.fusengdes.2015.06.176

The replacement strategy of the massive Multi-Module Blanket Segments (MMS) is a key driver in the design of several DEMO systems. These include the blankets themselves, the vacuum vessel (VV) and its ports and the Remote Maintenance System (RMS). Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9685e4044dc3afe0eef9e9fcf2504a
https://cris.vtt.fi/en/publications/ffd49943-217a-4434-abda-9a62868675c4