Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Roger B. Dodd"'
Autor:
Stacey E. Chin, Christina Schindler, Lisa Vinall, Roger B. Dodd, Lisa Bamber, Sandrine Legg, Anna Sigurdardottir, D. Gareth Rees, Tim I. M. Malcolm, Samantha J. Spratley, Cecilia Granéli, Jonathan Sumner, Natalie J. Tigue
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant interest within the synthetic biology community in identifying novel CID systems. To
Externí odkaz:
https://doaj.org/article/1c4fb2f0a98149f7bb083c8fbced398e
Publikováno v:
Methods. 180:111-126
Complex integral membrane proteins, which are embedded in the cell surface lipid bilayer by multiple transmembrane spanning helices, encompass families of proteins which are important target classes for drug discovery. These protein families include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853ae41aab44e96dc6fdd25d2569eae1
https://doi.org/10.1016/j.ymeth.2020.05.006
https://doi.org/10.1016/j.ymeth.2020.05.006
Autor:
Lisa-Maria Needham, Masahiro Enomoto, Yalun Zhang, Arturas Bruzas, Roger B. Dodd, Kanayo Satoh, David Klenerman, Fusheng Chen, Paul E. Fraser, Jean Sevalle, Steven F. Lee, Seema Qamar, Peter St George-Hyslop, Jochen Walter, David H. Allendorf, James Henderson, Jennifer K. Griffin, Guy C. Brown, Miguel Angel Burguillos, Suman De, Ye Zhou, Anna Vilalta, Mar Puigdellívol, Patrick Flagmeier
Missense mutations (e.g. R47H) of the microglial receptor TREM2 increase risk of Alzheimer’s disease (AD), and the soluble ectodomain of wild-type TREM2 (sTREM2) appears to protect in vivo, but the underlying mechanisms are unclear. We show that A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b68e4a017607189fee2054e1aa314424
https://doi.org/10.1101/2020.12.03.409995
https://doi.org/10.1101/2020.12.03.409995
Publikováno v:
BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 32(4)
Cell surface membrane proteins comprise a wide array of structurally and functionally diverse proteins involved in a variety of important physiological and homeostatic processes. Complex integral membrane proteins, which are embedded in the lipid bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f13c7f25224e62454466d291191fca
https://pubmed.ncbi.nlm.nih.gov/29934752
https://pubmed.ncbi.nlm.nih.gov/29934752
Autor:
F-F Chen, Roger B. Dodd, Gerold Schmitt-Ulms, PH St George-Hyslop, Yi Li, Seema Qamar, Christopher Bohm, Jean Sevalle, Paul E. Fraser
Publikováno v:
Molecular and Cellular Neurosciences
Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid β-peptide (Aβ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc080f87770d972e8594c14790c4a94
Autor:
Roger B. Dodd
Publikováno v:
Journal of Biological Chemistry. 293:12647-12648
Partial loss-of-function variants in the TREM2 immune receptor are associated with increased risk for Alzheimer's disease (AD) and other forms of neurodegenerative disease, but the molecular bases for these connections are unknown. Three new structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc9b9f668c36f6ba6056d474e61e63e
https://doi.org/10.1074/jbc.h118.004271
https://doi.org/10.1074/jbc.h118.004271
Autor:
Nora Cronin, David Barford, Andrew J. Thompson, Ioannis Manolaridis, Kiran Kulkarni, Ziguo Zhang, Sarah Hanrahan, Ganka Bineva, Roger B. Dodd, Satoshi Ogasawara, So Iwata, Nicola O’Reilly
Publikováno v:
Nature
CAAX proteins have essential roles in multiple signalling pathways, controlling processes such as proliferation, differentiation and carcinogenesis. The ∼120 mammalian CAAX proteins function at cellular membranes and include the Ras superfamily of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b97b0001a09954ebb22ada54c51c18
https://doi.org/10.1038/nature12754
https://doi.org/10.1038/nature12754
Autor:
David Barford, Ziguo Zhang, Kiran Kulkarni, Ioannis Manolaridis, Corine Mas-Droux, Jing Yang, Roger B. Dodd
Publikováno v:
Molecular Cell. 44:997-1004
Summary The posttranslational modification of C-terminal CAAX motifs in proteins such as Ras, most Rho GTPases, and G protein γ subunits, plays an essential role in determining their subcellular localization and correct biological function. An integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053e5da888eab1fa83c86a4fe87d412d
https://doi.org/10.1016/j.molcel.2011.10.020
https://doi.org/10.1016/j.molcel.2011.10.020
Autor:
Paul E. Fraser, Roger B. Dodd, Christopher Bohm, Fusheng Chen, Peter St George-Hyslop, Yi Li, Seema Qamar, Gerold Schmitt-Ulms
Publikováno v:
Molecular Neurodegeneration
The presenilin genes were first identified as the site of missense mutations causing early onset autosomal dominant familial Alzheimer's disease. Subsequent work has shown that the presenilin proteins are the catalytic subunits of a hetero-tetrameric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8bedb217bce3341781204b4046631c
https://doi.org/10.1186/1750-1326-9-59
https://doi.org/10.1186/1750-1326-9-59
Autor:
Mark Bycroft, Paul J. Lehner, Lidia M. Duncan, Mark D. Allen, Christopher M. Sanderson, Stephanie Brown, Randy J. Read, Roger B. Dodd
Publikováno v:
Journal of Biological Chemistry. 279:53840-53847
RING domains are found in a large number of eukaryotic proteins. Most function as E3 ubiquitin-protein ligases, catalyzing the terminal step in the ubiquitination process. Structurally, these domains have been characterized as binding two zinc ions i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9796f8df105d028e959c247b78b3e12e
https://doi.org/10.1074/jbc.m409662200
https://doi.org/10.1074/jbc.m409662200