Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Roger B. Slee"'
Autor:
Murray Korc, Brittney-Shea Herbert, Riccardo Colombo, Keith L. March, Jose Victorino, Jaesik Jeong, Rachel Gasaway, Lyndsey Brown, Corinne Blackburn, Jesse Gore, Ruchi Bansal, Brenda R. Grimes, Roger B. Slee
PDF - 1019K, Figure S1 The CIN70 signature predicts survival in PDAC patients. Figure S2 Murine PDAC KRC cells exhibit chromosome instability and evidence of a weakened SAC. Figure S3 Clonogenic survival of PANC-1 and BxPC3 cells treated with NMS-P71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e3cdeeafabfe46ea6e105727a39fea
https://doi.org/10.1158/1535-7163.22500747
https://doi.org/10.1158/1535-7163.22500747
Autor:
Murray Korc, Brittney-Shea Herbert, Riccardo Colombo, Keith L. March, Jose Victorino, Jaesik Jeong, Rachel Gasaway, Lyndsey Brown, Corinne Blackburn, Jesse Gore, Ruchi Bansal, Brenda R. Grimes, Roger B. Slee
Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b23d77188bf5b3b19e363caa90ed77
https://doi.org/10.1158/1535-7163.c.6536565.v1
https://doi.org/10.1158/1535-7163.c.6536565.v1
Autor:
Brenda R. Grimes, Roger B. Slee, Nazmul Huda, David Gilley, LiRen Tu, Liang Cheng, Alison M. Bates
Publikováno v:
Molecular Carcinogenesis. 55:842-852
A critical function of the telomere is to disguise chromosome ends from cellular recognition as double strand breaks, thereby preventing aberrant chromosome fusion events. Such chromosome end-to-end fusions are known to initiate genomic instability v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e94e64e52bb2c00893e89a5f0f4cb51
https://doi.org/10.1002/mc.22326
https://doi.org/10.1002/mc.22326
Autor:
Roger B. Slee, Milan Radovich, Gail H. Vance, Brittney-Shea Herbert, D. Schindelhauer, Brenda R. Grimes, S. Christan, Robert J. Hickey, Camie M. Steiner, T. Schwarz, Bryan P. Schneider
Publikováno v:
Oncogene. 31:3244-3253
Many tumors exhibit elevated chromosome mis-segregation termed chromosome instability (CIN), which is likely to be a potent driver of tumor progression and drug resistance. Causes of CIN are poorly understood but probably include prior genome tetrapl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9596f423b2bc2c81dbe42fe9cea4ddf0
https://doi.org/10.1038/onc.2011.502
https://doi.org/10.1038/onc.2011.502
Autor:
Virginia C. Thurston, Brian Johnstone, Camie M. Steiner, Amy M. Breman, Stephanie Merfeld-Clauss, Angela Reese, Danielle Smith, Brenda R. Grimes, Keith L. March, Gail H. Vance, Dmitry O. Traktuev, Roger B. Slee
Publikováno v:
Stem Cells and Development. 18:717-724
Human adipose stromal cells (ASCs) reside within the stromal-vascular fraction (SVF) in fat tissue, can be readily isolated, and include stem-like cells that may be useful for therapy. An important consideration for clinical application and functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9f4dc499fb0644d4243a63100daff0
https://doi.org/10.1089/scd.2008.0255
https://doi.org/10.1089/scd.2008.0255
Autor:
Michael J. Klemsz, Brandon A. Mann, Roger B. Slee, Mark H. Kaplan, Julia H. Huang, Audrey O’Sullivan, Mathur Anita, Ping Li, Hua-Chen Chang, Randy R. Brutkiewicz, Janice S. Blum, Norman Yeh
Publikováno v:
Journal of Interferon & Cytokine Research. 28:367-380
Blocking the function of Stat (signal transducer and activator of transcription) proteins, which are critical for antiviral responses, has evolved as a common mechanism for pathogen immune evasion. The poxvirus-encoded phosphatase H1 is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8606012077214cfadbfb4abb8e99c237
https://doi.org/10.1089/jir.2007.0113
https://doi.org/10.1089/jir.2007.0113
Publikováno v:
Molecular Therapy. 16:315-323
Human artificial chromosomes (ACs) are non-integrating vectors that may be useful for gene therapy. They assemble in cultured cells following transfection of human centromeric alpha -satellite DNA and segregate efficiently alongside the host genome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1465438ea2ce285a2b86353f4ad873d0
https://doi.org/10.1038/sj.mt.6300361
https://doi.org/10.1038/sj.mt.6300361
Autor:
LiRen, Tu, Nazmul, Huda, Brenda R, Grimes, Roger B, Slee, Alison M, Bates, Liang, Cheng, David, Gilley
Publikováno v:
Molecular carcinogenesis. 55(5)
A critical function of the telomere is to disguise chromosome ends from cellular recognition as double strand breaks, thereby preventing aberrant chromosome fusion events. Such chromosome end-to-end fusions are known to initiate genomic instability v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c87c904af006df9a2985fcde0d955530
https://pubmed.ncbi.nlm.nih.gov/25917938
https://pubmed.ncbi.nlm.nih.gov/25917938
Autor:
Riccardo Colombo, Brenda R. Grimes, Roger B. Slee, Lyndsey Brown, Corinne Blackburn, Keith L. March, Jaesik Jeong, Murray Korc, Rachel Gasaway, Jesse Gore, Jose F. Victorino, Brittney-Shea Herbert, Ruchi Bansal
Publikováno v:
Molecular cancer therapeutics. 13(2)
Most solid tumors, including pancreatic ductal adenocarcinoma (PDAC), exhibit structural and numerical chromosome instability (CIN). Although often implicated as a driver of tumor progression and drug resistance, CIN also reduces cell fitness and pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a65685856102ac554e5912b4b98436
https://pubmed.ncbi.nlm.nih.gov/24282275
https://pubmed.ncbi.nlm.nih.gov/24282275
Autor:
Vivian T. Thieu, Roger B. Slee, Shangming Zhang, Heather A. Bruns, Hua Chen Chang, Mark H. Kaplan, Michael J. Klemsz, R. Nicholas Laribee
Publikováno v:
Immunity. 22(6)
SummaryPrimary T helper 2 cells are heterogeneous, expressing subsets of cytokines at varying levels. Mechanisms controlling this spectrum of phenotypes are still unclear. The ETS family transcription factor PU.1 is expressed in Th2 but not Th1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67eef4212a57f04c6468afe2def53a2f
https://pubmed.ncbi.nlm.nih.gov/15963784
https://pubmed.ncbi.nlm.nih.gov/15963784