Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Roger A. Rajewski"'
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Akademický článek
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
Autor: Anuradha Illendula, Jane Gilmour, Jolanta Grembecka, Venkata Sesha Srimath Tirumala, Adam Boulton, Aravinda Kuntimaddi, Charles Schmidt, Lixin Wang, John A. Pulikkan, Hongliang Zong, Mahmut Parlak, Cem Kuscu, Anna Pickin, Yunpeng Zhou, Yan Gao, Lauren Mishra, Mazhar Adli, Lucio H. Castilla, Roger A. Rajewski, Kevin A. Janes, Monica L. Guzman, Constanze Bonifer, John H. Bushweller
Publikováno v: EBioMedicine, Vol 8, Iss C, Pp 117-131 (2016)
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewa
Externí odkaz: https://doaj.org/article/850cfca578ff44cc88f4d9d260010cb6
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5
Data from A Second-Generation 2-Methoxyestradiol Prodrug Is Effective against Barrett's Adenocarcinoma in a Mouse Xenograft Model
Autor: Sushanta K. Banerjee, Peter J. Van Veldhuizen, Emma Borrego-Diaz, Douglas Burns, Saheli Jha, Snigdha Banerjee, Amlan Das, Inamul Haque, Mehmet Tanol, Roger A. Rajewski, Suman Kambhampati
2-Methoxyestradiol (2-ME2) is an endogenous metabolite of estradiol. In preclinical models, 2-ME2 is effective against different types of tumors. Unfortunately, only low systemic concentrations of 2-ME2 can be achieved following oral administration,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b59b8ee75a277902dad405b0ca682a
https://doi.org/10.1158/1535-7163.c.6535956
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6
Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition
Autor: John H. Bushweller, Yan Gao, Roger A. Rajewski, Anant Shah, Adam Boulton, Anne L. Carlton, Anuradha Illendula, David Wotton, Danielle C. Llaneza, Charles N. Landen
Publikováno v: Gynecologic Oncology. 149:350-360
Objective Ovarian cancer survival and treatment have improved minimally in the past 20years. Novel treatment strategies are needed to combat this disease. This study investigates the effects of chemical inhibition of the CBFβ/RUNX protein-protein in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b90919992db9b5f4b63c7de97672aeb
https://doi.org/10.1016/j.ygyno.2018.03.005
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7
A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells
Autor: Isaura M. Frost, Roger A. Rajewski, John H. Bushweller, Trista E. North, Charles Schmidt, Anuradha Illendula, Zaw Min Oo, Wanda Kwan, Yunpeng Zhou, Jolanta Grembecka, Virginie Esain, Nancy A. Speck
Publikováno v: Leukemia & Lymphoma. 59:2188-2200
The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including t(8;21) in acute myeloid leukemia (AML). Normal CBF function is essential for activity of AML1-ETO, product of the t(8;21), and for survival of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae6c9a8efff6ff1311ccec6a1b1578d9
https://doi.org/10.1080/10428194.2017.1410882
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8
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers
Autor: Lauren Mishra, Mahmut Parlak, Adam Boulton, Cem Kuscu, Venkata Sesha Srimath Tirumala, Mazhar Adli, Yunpeng Zhou, John H. Bushweller, Anuradha Illendula, Yan Gao, Anna Pickin, Charles Schmidt, Jane Gilmour, Kevin A. Janes, John Anto Pulikkan, Roger A. Rajewski, Aravinda Kuntimaddi, Jolanta Grembecka, Lucio H. Castilla, Hongliang Zong, Constanze Bonifer, Monica L. Guzman, Lixin Wang
Publikováno v: EBioMedicine, Vol 8, Iss C, Pp 117-131 (2016)
Scipedia Open Access
Scipedia SL
Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc437935f8e8d7537d744c3567746b60
http://www.sciencedirect.com/science/article/pii/S235239641630175X
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9
Sulfobutylether-β-cyclodextrin
Autor: Roger A. Rajewski, Valentino J. Stella
Publikováno v: International Journal of Pharmaceutics
Graphical abstract
This review presents the early history, the motivation, the research and some of the backstories behind the discovery and development of sulfobutylether-β-cyclodextrin as a novel parenterally safe solubilizer and stabilizer.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38d45756fdeb07aa12778b6660816ff
https://doi.org/10.1016/j.ijpharm.2020.119396
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10
A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice
Autor: Roger A. Rajewski, Hongliang Zong, Adam Boulton, Yunpeng Zhou, John Anto Pulikkan, Aravinda Kuntimaddi, Anuradha Illendula, John H. Bushweller, Yan Gao, Liting Xue, Monica L. Guzman, Siddhartha Sen, Jolanta Grembecka, Lucio H. Castilla
Publikováno v: Science. 347:779-784
Toward drugging the undruggable in cancer Many human cancers are characterized by inappropriate activity of transcription factors. These proteins are attractive drug targets in principle, but normalizing their function requires drugs that modulate sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef2ac529ed66a037c3e2cab48b02492
https://doi.org/10.1126/science.aaa0314
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