Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Roger A. Pedersen"'
Autor:
Dorota Zawada, Jessica Kornherr, Anna B. Meier, Gianluca Santamaria, Tatjana Dorn, Monika Nowak-Imialek, Daniel Ortmann, Fangfang Zhang, Mark Lachmann, Martina Dreßen, Mariaestela Ortiz, Victoria L. Mascetti, Stephen C. Harmer, Muriel Nobles, Andrew Tinker, Maria Teresa De Angelis, Roger A. Pedersen, Phillip Grote, Karl-Ludwig Laugwitz, Alessandra Moretti, Alexander Goedel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying h
Externí odkaz:
https://doaj.org/article/10a747d5fcc140e6a38c4095415e2a1f
Allele-specific RNA-seq expression profiling of imprinted genes in mouse isogenic pluripotent states
Autor:
René A. M. Dirks, Guido van Mierlo, Hindrik H. D. Kerstens, Andreia S. Bernardo, Julianna Kobolák, István Bock, Julien Maruotti, Roger A. Pedersen, András Dinnyés, Martijn A. Huynen, Alice Jouneau, Hendrik Marks
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-21 (2019)
Abstract Background Genomic imprinting, resulting in parent-of-origin specific gene expression, plays a critical role in mammalian development. Here, we apply allele-specific RNA-seq on isogenic B6D2F1 mice to assay imprinted genes in tissues from ea
Externí odkaz:
https://doaj.org/article/ccab5f203e284c20b12ae65e88095907
Autor:
Matthias Pawlowski, Daniel Ortmann, Alessandro Bertero, Joana M. Tavares, Roger A. Pedersen, Ludovic Vallier, Mark R.N. Kotter
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 803-812 (2017)
Summary: The isolation or in vitro derivation of many human cell types remains challenging and inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression of transcription factors provides a potential alternative. Howe
Externí odkaz:
https://doaj.org/article/594d5418d1c949c7875666a1d7d874ca
Autor:
Aster H. Juan, Stan Wang, Kyung Dae Ko, Hossein Zare, Pei-Fang Tsai, Xuesong Feng, Karinna O. Vivanco, Anthony M. Ascoli, Gustavo Gutierrez-Cruz, Jordan Krebs, Simone Sidoli, Adam L. Knight, Roger A. Pedersen, Benjamin A. Garcia, Rafael Casellas, Jizhong Zou, Vittorio Sartorelli
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1369-1382 (2016)
Summary: The polycomb repressive complex 2 (PRC2) methylates lysine 27 of histone H3 (H3K27) through its catalytic subunit Ezh2. PRC2-mediated di- and tri-methylation (H3K27me2/H3K27me3) have been interchangeably associated with gene repression. Howe
Externí odkaz:
https://doaj.org/article/4790dc579ba94415bc2378a7c18b3b48
Autor:
Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Platelets are blood circulating corpuscles generated from megakaryocytes that initiate wound healing. Here, Moreau et al. describe a way of producing large quantities of megakaryocytes from human pluripotent stem cells in the laboratory, moving us a
Externí odkaz:
https://doaj.org/article/b82350820ade4d9ab86b9baef9fb56db
Autor:
Andreia S. Bernardo, Alice Jouneau, Hendrik Marks, Philip Kensche, Julianna Kobolak, Kristine Freude, Vanessa Hall, Anita Feher, Zsuzsanna Polgar, Chiara Sartori, Istvan Bock, Claire Louet, Tiago Faial, Hindrik H. D. Kerstens, Camille Bouissou, Gregory Parsonage, Kaveh Mashayekhi, James C. Smith, Giovanna Lazzari, Poul Hyttel, Hendrik G. Stunnenberg, Martijn Huynen, Roger A. Pedersen, Andras Dinnyes
Publikováno v:
Biology Open, Vol 7, Iss 8 (2018)
During early mammalian development, transient pools of pluripotent cells emerge that can be immortalised upon stem cell derivation. The pluripotent state, ‘naïve’ or ‘primed’, depends on the embryonic stage and derivation conditions used. He
Externí odkaz:
https://doaj.org/article/c7dcadce61d94f648a649a416ee01f36
Autor:
Michele Bertacchi, Giuseppe Lupo, Luca Pandolfini, Simona Casarosa, Mara D’Onofrio, Roger A. Pedersen, William A. Harris, Federico Cremisi
Publikováno v:
Stem Cell Reports, Vol 5, Iss 4, Pp 532-545 (2015)
Retinal progenitors are initially found in the anterior neural plate region known as the eye field, whereas neighboring areas undertake telencephalic or hypothalamic development. Eye field cells become specified by switching on a network of eye field
Externí odkaz:
https://doaj.org/article/3e650a27161a4010b717039edbea4010
Autor:
Thomas Moreau, Amanda L. Evans, Louella Vasquez, Marloes R. Tijssen, Ying Yan, Matthew W. Trotter, Daniel Howard, Maria Colzani, Meera Arumugam, Wing Han Wu, Amanda Dalby, Riina Lampela, Guenaelle Bouet, Catherine M. Hobbs, Dean C. Pask, Holly Payne, Tatyana Ponomaryov, Alexander Brill, Nicole Soranzo, Willem H. Ouwehand, Roger A. Pedersen, Cedric Ghevaert
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 7 Article number: 11208 (2016) Published 7 April 2016; Updated 28 July 2017 This Article contains an error in the author contributions section that has resulted in incorrect credit for preparation and critical analysis of the ma
Externí odkaz:
https://doaj.org/article/daa5e8c7f4144c119108ee825b318bf2
Autor:
Giuseppe Lupo, Claire Novorol, Joseph R. Smith, Ludovic Vallier, Elena Miranda, Morgan Alexander, Stefano Biagioni, Roger A. Pedersen, William A. Harris
Publikováno v:
Open Biology, Vol 3, Iss 4 (2013)
Several studies have successfully produced a variety of neural cell types from human embryonic stem cells (hESCs), but there has been limited systematic analysis of how different regional identities are established using well-defined differentiation
Externí odkaz:
https://doaj.org/article/1c9ccafab46245569a154766c82cb05c
Autor:
Yuliang Feng, Liuyang Cai, Wanzi Hong, Chunxiang Zhang, Ning Tan, Mingyang Wang, Cheng Wang, Feng Liu, Xiaohong Wang, Jianyong Ma, Chen Gao, Mohit Kumar, Yuanxi Mo, Qingshan Geng, Changjun Luo, Yan Lin, Haiyang Chen, Shuang-Yin Wang, Michael J. Watson, Anil G. Jegga, Roger A. Pedersen, Ji-dong Fu, Zhao V. Wang, Guo-Chang Fan, Sakthivel Sadayappan, Yigang Wang, Siim Pauklin, Feng Huang, Wei Huang, Lei Jiang
Publikováno v:
Circulation
Background: Transcriptional reconfiguration is central to heart failure, the most common cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin topology on transcriptional dysregulation and pathogenesis in human DCM rem