Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Roger A. Johns"'
Autor:
Li Gao, John Skinner, Tanmay Nath, Qing Lin, Megan Griffiths, Rachel L. Damico, Michael W. Pauciulo, William C. Nichols, Paul M. Hassoun, Allen D. Everett, Roger A. Johns
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Abnormal remodeling of distal pulmonary arteries in patients with pulmonary arterial hypertension (PAH) leads to progressively increased pulmonary vascular resistance, followed by right ventricular hypertrophy and failure. Despite
Externí odkaz:
https://doaj.org/article/6ca03ee34a4e496ca26a6aba6d9e3633
Autor:
Qing Lin, Santosh Kumar, Udeshika Kariyawasam, Xiaomei Yang, Wei Yang, John T. Skinner, Wei Dong Gao, Roger A. Johns
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 6 (2023)
Background Cardiac failure is the primary cause of death in most patients with pulmonary arterial hypertension (PH). As pleiotropic cytokines, human resistin (Hresistin) and its rodent homolog, resistin‐like molecule α, are mechanistically critica
Externí odkaz:
https://doaj.org/article/e68e55d438bc4e53bd260e3a5ed84a22
Autor:
Taejoon Won, Megan K. Wood, David M. Hughes, Monica V. Talor, Zexu Ma, Jowaly Schneider, John T. Skinner, Beejan Asady, Erin Goerlich, Marc K. Halushka, Allison G. Hays, Deok-Ho Kim, Chirag R. Parikh, Avi Z. Rosenberg, Isabelle Coppens, Roger A. Johns, Nisha A. Gilotra, Jody E. Hooper, Andrew Pekosz, Daniela Čiháková
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103812- (2022)
Summary: Background: Thromboembolism is a life-threatening manifestation of coronavirus disease 2019 (COVID-19). We investigated a dysfunctional phenotype of vascular endothelial cells in the lungs during COVID-19. Methods: We obtained the lung speci
Externí odkaz:
https://doaj.org/article/fa15652ffd1a47a2a1954f6284a33f0d
Autor:
Bingdong Tao, Santosh Kumar, Jose Gomez-Arroyo, Chunling Fan, Ailan Zhang, John Skinner, Elizabeth Hunter, Kazuyo Yamaji-Kegan, Idris Samad, Alexander T. Hillel, Qing Lin, Wenqian Zhai, Wei Dong Gao, Roger A. Johns
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Heart (right) failure is the most frequent cause of death in patients with pulmonary arterial hypertension. Although historically, increased right ventricular afterload has been considered the main contributor to right heart failure in such patients,
Externí odkaz:
https://doaj.org/article/f29ef73514ca420290ba166d9301c24a
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
Right ventricular (RV) failure (RVF) has garnered significant attention in recent years because of its negative impact on clinical outcomes in patients with pulmonary hypertension (PH). PH triggers a series of events, including activation of several
Externí odkaz:
https://doaj.org/article/3dc20aeb1e984debb4b686897e826ce9
Publikováno v:
Anesthesiology. 137(2)
Background Inhalational anesthetics are known to disrupt PDZ2 domain–mediated protein–protein interactions of the postsynaptic density (PSD)-95 protein. The aim of this study is to investigate the underlying mechanisms in response to early isoflu
Autor:
Diana H. Yu, Qing Lin, Chunling Fan, John T. Skinner, Jeffrey P. Thiboutot, Lonny B. Yarmus, Roger A. Johns
Publikováno v:
Journal of Bronchology & Interventional Pulmonology.
The inflammatory role of dysregulated IRS2 in pulmonary vascular remodeling under hypoxic conditions
Autor:
Qing Lin, Homare Ito, Achsah D. Keegan, Kazuyo Yamaji-Kegan, Roger A. Johns, Rasa Tamosiuniene, John Skinner, Mark R. Nicolls, Mayumi Nakahara
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Pulmonary hypertension (PH) is a devastating disease characterized by progressive elevation of pulmonary vascular resistance, right ventricular failure, and ultimately death. We have shown previously that insulin receptor substrate 2 (IRS2), a molecu
Autor:
Roger A. Johns
Publikováno v:
ASA Monitor. 87:e6-e6
Autor:
Qing Lin, Roger A. Johns
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The family of resistin-like molecules (RELMs) consists of four members in rodents (RELMα/FIZZ1/HIMF, RELMβ/FIZZ2, Resistin/FIZZ3, and RELMγ/FIZZ4) and two members in humans (Resistin and RELMβ), all of which exhibit inflammation-regulating, chemo