Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Roger A. Brooks"'
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract Aim The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesions. We sought to determine
Externí odkaz:
https://doaj.org/article/c24a7a6343234f319f052ab9eced8415
Publikováno v:
Bone & Joint Research, Vol 10, Iss 9, Pp 611-618 (2021)
Aims: Accumulated evidence indicates that local cell origins may ingrain differences in the phenotypic activity of human osteoblasts. We hypothesized that these differences may also exist in osteoblasts harvested from the same bone type at periarticu
Externí odkaz:
https://doaj.org/article/0bb121740edb4696af6516ee42f0c82b
Autor:
Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthriti
Externí odkaz:
https://doaj.org/article/dcec7e1450ec48c58e6b36aa6fd093ff
Autor:
Julia Steinberg, Graham R. S. Ritchie, Theodoros I. Roumeliotis, Raveen L. Jayasuriya, Matthew J. Clark, Roger A. Brooks, Abbie L. A. Binch, Karan M. Shah, Rachael Coyle, Mercedes Pardo, Christine L. Le Maitre, Yolande F. M. Ramos, Rob G. H. H. Nelissen, Ingrid Meulenbelt, Andrew W. McCaskie, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint remodeling. The underlying molecular changes underpinning disease progression are incompletely understood. We investigated genes and pathways that mark
Externí odkaz:
https://doaj.org/article/1131f568f3274d8e84be794049aae9e8
Autor:
Karin H. Müller, Robert Hayward, Rakesh Rajan, Meredith Whitehead, Andrew M. Cobb, Sadia Ahmad, Mengxi Sun, Ieva Goldberga, Rui Li, Uliana Bashtanova, Anna M. Puszkarska, David G. Reid, Roger A. Brooks, Jeremy N. Skepper, Jayanta Bordoloi, Wing Ying Chow, Hartmut Oschkinat, Alex Groombridge, Oren A. Scherman, James A. Harrison, Anja Verhulst, Patrick C. D’Haese, Ellen Neven, Lisa-Maria Needham, Steven F. Lee, Catherine M. Shanahan, Melinda J. Duer
Publikováno v:
Cell Reports, Vol 27, Iss 11, Pp 3124-3138.e13 (2019)
Summary: Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell bi
Externí odkaz:
https://doaj.org/article/2e647e91d7844530b22e541687279a3e
Autor:
David G. Reid, Catherine M. Shanahan, Melinda J. Duer, Luis G. Arroyo, Michael Schoppet, Roger A. Brooks, Rachel C. Murray
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 8, Pp 1569-1575 (2012)
Pathomechanisms underlying vascular calcification biogenesis are still incompletely understood. Biomineral from human atherosclerotic intimal plaques; human, equine, and bovine medial vascular calcifications; and human and equine bone was released fr
Externí odkaz:
https://doaj.org/article/21adecc1f106460bb82acaf765c67da3
Publikováno v:
European Journal of Operational Research. 309:1286-1299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e0b2422432bf6836f6b48cd6985c249
https://doi.org/10.1016/j.ejor.2022.11.012
https://doi.org/10.1016/j.ejor.2022.11.012
Publikováno v:
European Journal of Operational Research. 296:1025-1035
This paper is the first to consider different methods for rating professional snooker players based on their past performance. The official World Rankings (based on prize money earned) and a player's win percentage are considered, along with paired c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aee95a7cb1a69399c37cf8fff4f14a7
https://doi.org/10.1016/j.ejor.2021.04.056
https://doi.org/10.1016/j.ejor.2021.04.056
Publikováno v:
Bone & Joint Research, Vol 10, Iss 9, Pp 611-618 (2021)
Bone & Joint Research
Bone & Joint Research
Aims Accumulated evidence indicates that local cell origins may ingrain differences in the phenotypic activity of human osteoblasts. We hypothesized that these differences may also exist in osteoblasts harvested from the same bone type at periarticul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb931442c267a12ee28a0597630392ab
https://doi.org/10.1302/2046-3758.109.bjr-2020-0497.r1
https://doi.org/10.1302/2046-3758.109.bjr-2020-0497.r1
Autor:
Eleftheria Zeggini, D Swift, Julia Steinberg, Roger A. Brooks, Raveen L Jayasuriya, Karan M. Shah, Andreas Fontalis, Jeremy Mark Wilkinson, Andrew McCaskie, Lorraine Southam, M.J. Clark
Publikováno v:
Ann. Rheum. Dis. 80, 1070-1074 (2021)
Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases
ObjectivesTo determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm.MethodsWe analysed RNA sequencing dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce3d6f0469010e6e43ee6a14c2ef542
https://doi.org/10.1136/annrheumdis-2020-219760
https://doi.org/10.1136/annrheumdis-2020-219760