Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Roger A. Ashmus"'
Autor:
Manuel González-Cuesta, Irene Herrera-González, M. Isabel García-Moreno, Roger A. Ashmus, David J. Vocadlo, José M. García Fernández, Eiji Nanba, Katsumi Higaki, Carmen Ortiz Mellet
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1364-1374 (2022)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its trafficking to the lysosome
Externí odkaz:
https://doaj.org/article/669c8768aeed4cfeb39c9878c1d290c2
Autor:
Alba L. Montoya, Victoria M. Austin, Susana Portillo, Irodiel Vinales, Roger A. Ashmus, Igor Estevao, Sohan R. Jankuru, Yasser Alraey, Waleed S. Al-Salem, Álvaro Acosta-Serrano, Igor C. Almeida, Katja Michael
Publikováno v:
JACS Au, Vol 1, Iss 8, Pp 1275-1287 (2021)
Externí odkaz:
https://doaj.org/article/843c25e9b1764fc690a171137409d8c8
Autor:
Alba L. Montoya, Elisa G. Carvajal, Uriel Ortega-Rodriguez, Igor L. Estevao, Roger A. Ashmus, Sohan R. Jankuru, Susana Portillo, Cameron C. Ellis, Colin D. Knight, Julio Alonso-Padilla, Luis Izquierdo, Maria-Jesus Pinazo, Joaquim Gascon, Veronica Suarez, Douglas M. Watts, Iliana R. Malo, Janine M. Ramsey, Belkisyolé Alarcón De Noya, Oscar Noya, Igor C. Almeida, Katja Michael
Publikováno v:
Molecules, Vol 27, Iss 17, p 5714 (2022)
Chagas disease (CD) is caused by the parasite Trypanosoma cruzi and affects 6–7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity encompassing seven genotypes (TcI-VI and Tcbat) with diverse ecoepidem
Externí odkaz:
https://doaj.org/article/8bc33462f2704c6c873a0a69be92794a
Autor:
Roger A. Ashmus, Yang Wang, Manuel González-Cuesta, Dustin T. King, Ben Tiet, Xi Chen, Yanping Zhu, Bryce Kirk, Jos é M. García Fernandez, Carmen Ortiz Mellet, Robert Britton, David J Vocadlo
Publikováno v:
Chemistry – A European Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ceaca1b6ef7c432eb2461ae7226b3e8
https://doi.org/10.1002/chem.202300982
https://doi.org/10.1002/chem.202300982
Autor:
Samy Cecioni, Roger A. Ashmus, Pierre-André Gilormini, Sha Zhu, Xi Chen, Xiaoyang Shan, Christina Gros, Matthew C. Deen, Yang Wang, Robert Britton, David J. Vocadlo
Publikováno v:
Nature Chemical Biology. 18:332-341
Understanding the function and regulation of enzymes within their physiologically relevant milieu requires quality tools that report on their cellular activities. Here we describe a strategy for glycoside hydrolases that overcomes several limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d7c089bb8d1ad247ea1560a58f299d
https://doi.org/10.1038/s41589-021-00960-x
https://doi.org/10.1038/s41589-021-00960-x
Autor:
Manuel, González-Cuesta, Irene, Herrera-González, M Isabel, García-Moreno, Roger A, Ashmus, David J, Vocadlo, José M, García Fernández, Eiji, Nanba, Katsumi, Higaki, Carmen, Ortiz Mellet
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 37(1)
The late-onset form of Tay-Sachs disease displays when the activity levels of human β-hexosaminidase A (HexA) fall below 10% of normal, due to mutations that destabilise the native folded form of the enzyme and impair its trafficking to the lysosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8213840dd5729886934f2caecee98e7d
https://pubmed.ncbi.nlm.nih.gov/35575117
https://pubmed.ncbi.nlm.nih.gov/35575117
Autor:
Manuel González-Cuesta, Peter Sidhu, Roger A. Ashmus, Alexandra Males, Cameron Proceviat, Zarina Madden, Jason C. Rogalski, Jil A. Busmann, Leonard J. Foster, José M. García Fernández, Gideon J. Davies, Carmen Ortiz Mellet, David J. Vocadlo
Publikováno v:
Journal of the American Chemical Society. 144(2)
Owing to its roles in human health and disease, the modification of nuclear, cytoplasmic, and mitochondrial proteins with O-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3658ecaf8f20742f6ee3479a34644cc
https://pubmed.ncbi.nlm.nih.gov/34985906
https://pubmed.ncbi.nlm.nih.gov/34985906
Autor:
Carmen Ortiz Mellet, Manuel González-Cuesta, José M. García Fernández, Ben Tiet, David J. Vocadlo, Yang Wang, Dustin T. King, Pierre-André Gilormini, Robert Britton, Roger A. Ashmus
Publikováno v:
Organicbiomolecular chemistry. 19(37)
We report the rational design and synthesis of C2-modified DGJ analogues to improve the selective inhibition of human GALA over other glycosidases. We prepare these analogues using a concise route from non-carbohydrate materials and demonstrate the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9f2bf1985dfe3b83c1e20851cfb9c4
https://pubmed.ncbi.nlm.nih.gov/34494637
https://pubmed.ncbi.nlm.nih.gov/34494637
Autor:
Waleed S. Al-Salem, Igor Estevao, Susana Portillo, Sohan R. Jankuru, Irodiel Vinales, Alba Montoya, Victoria M. Austin, Igor C. Almeida, Alvaro Acosta-Serrano, Yasser Alraey, Katja Michael, Roger A. Ashmus
Publikováno v:
JACS Au, Vol 1, Iss 8, Pp 1275-1287 (2021)
All healthy humans have high levels of natural anti-α-galactosyl (α-Gal) antibodies (elicited by yet uncharacterized glycotopes), which may play important roles in immunoglycomics: (a) potential protection against certain parasitic and viral zoonot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cabf7d362189b366bfcd626ea629e349
https://archive.lstmed.ac.uk/18758/1/jacsau.1c00201.pdf
https://archive.lstmed.ac.uk/18758/1/jacsau.1c00201.pdf
Autor:
Katja Michael, Nathaniel S. Schocker, Roger A. Ashmus, Mina Mesri, Igor C. Almeida, Krishanthi Subramaniam, Matthew S. Anderson, Alba Montoya, Waleed S. Al-Salem, Victoria M. Austin, Alvaro Acosta-Serrano
Publikováno v:
Parasitology. 145:1758-1764
Outbreaks of Old World cutaneous leishmaniasis (CL) have significantly increased due to the conflicts in the Middle East, with most of the cases occurring in resource-limited areas such as refugee settlements. The standard methods of diagnosis includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28236e4cf71085ce29da1c6914507f40
https://doi.org/10.1017/s0031182018000860
https://doi.org/10.1017/s0031182018000860