Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Roger A H Adan"'
Autor:
Rahul Pandit, Esther M van der Zwaal, Mieneke C M Luijendijk, Maike A D Brans, Andrea J van Rozen, Ralph J A Oude Ophuis, Louk J M J Vanderschuren, Roger A H Adan, Susanne E la Fleur
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121768 (2015)
The role of the melanocortin (MC) system in feeding behavior is well established. Food intake is potently suppressed by central infusion of the MC 3/4 receptor agonist α-melanocyte stimulating hormone (α-MSH), whereas the MC 3/4 receptor inverse-ag
Externí odkaz:
https://doaj.org/article/bfb2daf3a5c54291920b266807b47ab6
Autor:
José K van den Heuvel, Leslie Eggels, Eric Fliers, Andries Kalsbeek, Roger A H Adan, Susanne E la Fleur
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87729 (2014)
ObjectiveLeptin resistance is a common hallmark of obesity. Rats on a free-choice high-fat high-sugar (fcHFHS) diet are resistant to peripherally administered leptin. The aim of this study was to investigate feeding responses to central leptin as wel
Externí odkaz:
https://doaj.org/article/8fc03ba1f2ba4710a08935f928b52dd9
Autor:
Margriet A van Gestel, Arjen J Boender, Veronne A J de Vrind, Keith M Garner, Mieneke C M Luijendijk, Roger A H Adan
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97639 (2014)
To promote the efficient and safe application of adeno-associated virus (AAV) vectors as a gene transfer tool in the central nervous system (CNS), transduction efficiency and clearance were studied for serotypes commonly used to transfect distinct ar
Externí odkaz:
https://doaj.org/article/e6449f4a4f1249b4851b7f3b61c5a391
Autor:
Arjen J Boender, Nivard A Koning, José K van den Heuvel, Mieneke C M Luijendijk, Andrea J van Rozen, Susanne E la Fleur, Roger A H Adan
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94159 (2014)
Several genome-wide association studies have implicated the transcription factor E-twenty- six version 5 (Etv5) in the regulation of body mass index. Further substantiating the role of Etv5 in feeding behavior are the findings that targeted disruptio
Externí odkaz:
https://doaj.org/article/067a313c3c09479293230465d6082cf1
Autor:
Arjen J Boender, Johannes W de Jong, Linde Boekhoudt, Mieneke C M Luijendijk, Geoffrey van der Plasse, Roger A H Adan
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95392 (2014)
We here describe a technique to transiently activate specific neural pathways in vivo. It comprises the combined use of a CRE-recombinase expressing canine adenovirus-2 (CAV-2) and an adeno-associated virus (AAV-hSyn-DIO-hM3D(Gq)-mCherry) that contai
Externí odkaz:
https://doaj.org/article/5f980d24999a4bbca76de1eb5407d933
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74645 (2013)
The worldwide obesity epidemic poses an enormous and growing threat to public health. However, the neurobehavioral mechanisms of overeating and obesity are incompletely understood. It has been proposed that addiction-like processes may underlie certa
Externí odkaz:
https://doaj.org/article/ce5d21ee8a0a4c7099b09f8f4cba8d70
Autor:
Elzbieta Kostrzewa, Annemarie A van Elburg, Nicole Sanders, Lot Sternheim, Roger A H Adan, Martien J H Kas
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78251 (2013)
OBJECTIVE:Patients with anorexia nervosa (AN) are often observed to have high levels of physical activity, which do not necessarily diminish after a successful therapy. Previous studies have shown that body fat tissue recovery in these patients is as
Externí odkaz:
https://doaj.org/article/7f84d7827b95477ea6213ad3fdd30e61
Autor:
Olaia Carrera, Roger A H Adan, Emilio Gutierrez, Unna N Danner, Hans W Hoek, Annemarie A van Elburg, Martien J H Kas
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41851 (2012)
Excessive physical activity is a common feature in Anorexia Nervosa (AN) that interferes with the recovery process. Animal models have demonstrated that ambient temperature modulates physical activity in semi-starved animals. The aim of the present s
Externí odkaz:
https://doaj.org/article/6b597070fd154e6d8d5a2f3d2521ad13
Autor:
Joram D Mul, Susanne E la Fleur, Pim W Toonen, Anthonieke Afrasiab-Middelman, Rob Binnekade, Dustin Schetters, Michel M M Verheij, Robert M Sears, Judith R Homberg, Anton N M Schoffelmeer, Roger A H Adan, Ralph J DiLeone, Taco J De Vries, Edwin Cuppen
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19600 (2011)
Current epidemic obesity levels apply great medical and financial pressure to the strenuous economy of obesity-prone cultures, and neuropeptides involved in body weight regulation are regarded as attractive targets for a possible treatment of obesity
Externí odkaz:
https://doaj.org/article/856a88d2de5d49c7b8dbdde7f3492dfd
Autor:
Lara Keller, Astrid Dempfle, Brigitte Dahmen, Samira Schreiber, Roger A. H. Adan, Nadia Andrea Andreani, Unna N. Danner, Albrecht Eisert, Sergueï Fetissov, Florian Ph. S. Fischmeister, Andreas Karwautz, Kerstin Konrad, Karlijn L. Kooij, Stefanie Trinh, Benny van der Vijgh, Annemarie A. van Elburg, Michael Zeiler, John Baines, Jochen Seitz, Beate Herpertz-Dahlmann
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-15 (2022)
Abstract Background Anorexia nervosa (AN) is a severe psychiatric disease that often takes a chronic course due to insufficient treatment options. Emerging evidence on the gut-brain axis offers the opportunity to find innovative treatments for patien
Externí odkaz:
https://doaj.org/article/28e12969d4164977be2b9af856cd67d2