Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Roger A Astley"'
Autor:
Phillip S Coburn, Brandt J Wiskur, Frederick C Miller, Austin L LaGrow, Roger A Astley, Michael H Elliott, Michelle C Callegan
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154560 (2016)
The blood-retinal barrier (BRB) functions to maintain the immune privilege of the eye, which is necessary for normal vision. The outer BRB is formed by tightly-associated retinal pigment epithelial (RPE) cells which limit transport within the retinal
Externí odkaz:
https://doaj.org/article/0d304751ffc24e7aa6dd2f2962ef3477
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28619 (2011)
Bacillus cereus causes a uniquely rapid and blinding intraocular infection, endophthalmitis. B. cereus replicates in the eye, synthesizes numerous toxins, and incites explosive intraocular inflammation. The mechanisms involved in the rapid and explos
Externí odkaz:
https://doaj.org/article/fd19d330798f47ef84563f4b1081e48e
Autor:
Roger A. Astley, Md Huzzatul Mursalin, Phillip S. Coburn, Erin T. Livingston, James W. Nightengale, Eddy Bagaruka, Jonathan J. Hunt, Michelle C. Callegan
Publikováno v:
Microorganisms, Vol 11, Iss 7, p 1802 (2023)
Ocular infections can be medical emergencies that result in permanent visual impairment or blindness and loss of quality of life. Bacteria are a major cause of ocular infections. Effective treatment of ocular infections requires knowledge of which ba
Externí odkaz:
https://doaj.org/article/16ee1795732946c7b946c5a9c120cc50
Autor:
Erin Livingston, Michelle C. Callegan, Roger A. Astley, Frederick C. Miller, Huzzatul Mursalin, Phillip S. Coburn
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to explore the C-X-C chemokines CXCL2 and CXCL10 as potential anti-inflammatory targets for Bacillus endophthalmitis. Methods Bacillus endophthalmitis was induced in C57BL/6J, CXCL2-/-, and CXCL10-/- mice. At spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20904c96b16c67f88bc041c59b21b7c
http://europepmc.org/articles/PMC8606850
http://europepmc.org/articles/PMC8606850
Autor:
Roger A. Astley, Didier Lereclus, Huzzatul Mursalin, Phillip S. Coburn, Michelle C. Callegan, Omar Amayem, Erin Livingston, Frederick C. Miller
Publikováno v:
Infection and Immunity. 89
Bacterial endophthalmitis is a devastating infection that can cause blindness following the introduction of organisms into the posterior segment of the eye. Over half of Bacillus endophthalmitis cases result in significant loss of useful vision. Ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c173c4f9ecbf602b747b85d99c9aae67
https://doi.org/10.1128/iai.00201-21
https://doi.org/10.1128/iai.00201-21
Autor:
Erin Livingston, Roger A. Astley, Huzzatul Mursalin, Michelle C. Callegan, Phillip S. Coburn, Frederick C. Miller
Publikováno v:
J Vis Exp
Intraocular bacterial infections are a danger to the vision. Researchers use animal models to investigate the host and bacterial factors and immune response pathways associated with infection to identify viable therapeutic targets and to test drugs t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421e1ed0e30133781ef191433d9a3674
https://pubmed.ncbi.nlm.nih.gov/33616100
https://pubmed.ncbi.nlm.nih.gov/33616100
Autor:
Craig Land, Phillip S. Coburn, So-Young Oh, Austin L. LaGrow, Roger A. Astley, Frederick C. Miller, Michelle C. Callegan, Salai Madhumathi Parkunan, Olaf Schneewind, C. Blake Randall
Publikováno v:
Experimental Eye Research. 159:69-76
Bacterial endophthalmitis is a potentially blinding intraocular infection. The bacterium Bacillus cereus causes a devastating form of this disease which progresses rapidly, resulting in significant inflammation and loss of vision within a few days. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a6ebf5069e33b1898a7635db38847b
https://doi.org/10.1016/j.exer.2017.03.007
https://doi.org/10.1016/j.exer.2017.03.007
Autor:
Roger A. Astley, C. Blake Randall, Glaucia C. Furtado, Sergio A. Lira, Salai Madhumathi Parkunan, Michelle C. Callegan
Publikováno v:
Journal of Leukocyte Biology. 100:1125-1134
During intraocular bacterial infections, the primary innate responders are neutrophils, which may cause bystander damage to the retina or perturb the clarity of the visual axis. We hypothesized that cytokine IL-6 and chemokine CXCL1 contributed to ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7321667e7c5a6cdf42d0f5880b0f028f
https://doi.org/10.1189/jlb.3a0416-173r
https://doi.org/10.1189/jlb.3a0416-173r
Autor:
Phillip S. Coburn, Frederick C. Miller, Michelle C. Callegan, Erin Livingston, Huzzatul Mursalin, Roger A. Astley
Publikováno v:
Investigative Ophthalmology & Visual Science
PURPOSEBacillusendophthalmitis is a sight-threatening bacterial infection that sometimes requires enucleation. Inflammation in this disease is driven by activation of innate Toll-like receptor (TLR) pathways. Here, we explored the consequences of inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c52d333728d7cb220a55105cb44cd1
https://doi.org/10.1167/iovs.61.13.17
https://doi.org/10.1167/iovs.61.13.17
Autor:
Salai Madhumathi Parkunan, Roger A. Astley, Michelle C. Callegan, Phillip S. Coburn, C. Blake Randall, Rachel L. Staats
Publikováno v:
Infection and Immunity. 83:3926-3936
Inflammation caused by infection with Gram-positive bacteria is typically initiated by interactions with Toll-like receptor 2 (TLR2). Endophthalmitis, an infection and inflammation of the posterior segment of the eye, can lead to vision loss when ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b55debb5aa1025dc13d88283aff3d13
https://doi.org/10.1128/iai.00502-15
https://doi.org/10.1128/iai.00502-15