Zobrazeno 1 - 10
of 392
pro vyhledávání: '"Roger A, Nicoll"'
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112146- (2023)
Summary: Calcium calmodulin-dependent kinase II (CaMKII) is critical for synaptic transmission and plasticity. Two major isoforms of CaMKII, CaMKIIα and CaMKIIβ, play distinct roles in synaptic transmission and long-term potentiation (LTP) with unk
Externí odkaz:
https://doaj.org/article/965a373f4a1848d2bcecd42d150388d7
Autor:
Wucheng Tao, Joel Lee, Xiumin Chen, Javier Díaz-Alonso, Jing Zhou, Samuel Pleasure, Roger A Nicoll
Publikováno v:
eLife, Vol 10 (2021)
Long-term potentiation (LTP) is arguably the most compelling cellular model for learning and memory. While the mechanisms underlying the induction of LTP (‘learning’) are well understood, the maintenance of LTP (‘memory’) has remained content
Externí odkaz:
https://doaj.org/article/139babb4c9564093be872a3227250095
Autor:
Javier Díaz-Alonso, Wade Morishita, Salvatore Incontro, Jeffrey Simms, Julia Holtzman, Michael Gill, Lennart Mucke, Robert C Malenka, Roger A Nicoll
Publikováno v:
eLife, Vol 9 (2020)
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results sup
Externí odkaz:
https://doaj.org/article/2a687e03a6294615a01f92954f148df5
Autor:
Gui-Fang Duan, Yaxin Ye, Sha Xu, Wucheng Tao, Shiping Zhao, Tengchuan Jin, Roger A. Nicoll, Yun Stone Shi, Nengyin Sheng
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies s
Externí odkaz:
https://doaj.org/article/cc781a02cb3d418899baa57e51f71444
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
Calcium-calmodulin-dependent protein kinase II (CaMKII) is well known for its roles in synaptic plasticity. Using a series of molecular replacement experiments, the authors show that the kinase function of CaMKII is required for long-term plasticity
Externí odkaz:
https://doaj.org/article/5fb48f87db034bfe9e462aad3de3908e
Autor:
Julie C. Ullman, Jing Yang, Michael Sullivan, Jacob Bendor, Jonathan Levy, Ellen Pham, Katlin Silm, Helia Seifikar, Vikaas S. Sohal, Roger A. Nicoll, Robert H. Edwards
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
The Na+/H+ exchanger NHE9 is proposed to regulate the H+ electrochemical gradient across endosomal membranes. Here, the authors find that NHE9 knockout mice show autism spectrum disorder-like behaviors and disrupted synaptic vesicle exocytosis due to
Externí odkaz:
https://doaj.org/article/92e65f596eb44f879ff6c2b988a111c2
Autor:
Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll, Javier Diaz-Alonso
Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 and MDGA2) are a family of synaptic organizers suggested to play an unusual rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ca99f368ad139fcfa61e0d6f1fcb49
https://doi.org/10.1101/2023.05.25.542333
https://doi.org/10.1101/2023.05.25.542333
Autor:
Salvatore Incontro, Javier Díaz-Alonso, Jillian Iafrati, Marta Vieira, Cedric S. Asensio, Vikaas S. Sohal, Katherine W. Roche, Kevin J. Bender, Roger A. Nicoll
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-2 (2018)
The originally published version of this Article contained errors in Figure 5, for which we apologise. In panel c, the scatter graph was inadvertently replaced with a scatter graph comprising a subset of data points from panel d. Furthermore, the leg
Externí odkaz:
https://doaj.org/article/285590a6c6aa43ccbe9bb83ced51b30c
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Activation of Ca 2+ /calmodulin-dependent kinase II (CaMKII) plays a critical role in long-term potentiation (LTP), a long accepted cellular model for learning and memory. However, how LTP and memories survive the turnover of synaptic proteins, parti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d740a59ded8394e3b5518d6212b9d37f
https://doi.org/10.1073/pnas.2211572119
https://doi.org/10.1073/pnas.2211572119
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 607-614 (2013)
Synaptic activity triggers a profound reorganization of the molecular composition of excitatory synapses. For example, NMDA receptors are removed from synapses in an activity- and calcium-dependent manner, via casein kinase 2 (CK2) phosphorylation of
Externí odkaz:
https://doaj.org/article/1d36bef6b1e9466fbad22174eb7a5252