Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Roger A, Kroes"'
Autor:
Gladys Morrison, Marina N. Asiedu, Jessica M. Priebe, Jacqueline Dunning, Nayereh Ghoreishi-Haack, Roger A. Kroes, M. Scott Bowers, Amanda L. Barth, Cassia N. Cearley, Joseph R. Moskal
Publikováno v:
Neurobiology of Pain, Vol 7, Iss , Pp - (2020)
Previous studies have shown that oral administration of the NMDAR modulator NYX-2925 alleviates pain in several animal models of neuropathic pain and this appears to be through mPFC, but not spinal, mediated mechanisms. While much is known about the
Externí odkaz:
https://doaj.org/article/135d2d36d9074a59aaae40a10aba95ab
Autor:
Norelle C. Wildburger, Cheryl F. Lichti, Richard D. LeDuc, Mary Schmidt, Roger A. Kroes, Joseph R. Moskal, Carol L. Nilsson
Publikováno v:
EuPA Open Proteomics, Vol 8, Iss C, Pp 94-103 (2015)
Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) show promise as cell-based delivery vehicles for anti-glioma therapeutics, due to innate tropism for gliomas. However, in clinically relevant human-in-mouse glioma stem cell xenograft models
Externí odkaz:
https://doaj.org/article/1246121ec9ef4c82972fd2a1cebfd6f9
Autor:
Srishti U. Sahu, M. Scott Bowers, Luisa P. Cacheaux, Joseph A. Sennello, Katherine Leaderbrand, Mary E. Schmidt, Joseph R. Moskal, M. Amin Khan, Roger A. Kroes
Publikováno v:
Journal of Neurochemistry
N‐methyl‐d‐aspartate receptors (NMDARs) mediate both physiological and pathophysiological processes, although selective ligands lack broad clinical utility. NMDARs are composed of multiple subunits, but N‐methyl‐d‐aspartate receptor subun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b46cab2807da9a4bb10479a5c931ac
http://europepmc.org/articles/PMC7065110
http://europepmc.org/articles/PMC7065110
Autor:
Roger A. Kroes, Cassia N. Cearley, Joseph R. Moskal, Jeffrey Burgdorf, Nayereh Ghoreishi-Haack
Publikováno v:
NeuroReport. 30:863-866
In humans, chronic pain is often expressed as a spontaneous emotional response which can lead to fragmented sleep. Rat 50-kHz and 20-kHz ultrasonic vocalizations are well-established measures of positive and negative emotional states, respectively. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4989527401c4e005684cb361ba236b7e
https://doi.org/10.1097/wnr.0000000000001282
https://doi.org/10.1097/wnr.0000000000001282
Autor:
Jan Kehr, Omid Miry, Patric K. Stanton, Amanda L. Gross, Joseph R. Moskal, Takashi Yoshitake, Xiao-Lei Zhang, Jeffery S. Burgdorf, Yong-Xin Li, Yuan Xing Guo, Roger A. Kroes, John E. Donello, Pradeep Banerjee
Publikováno v:
International Journal of Neuropsychopharmacology
Background Modulation of glutamatergic synaptic transmission by N-methyl-D-aspartate receptors can produce rapid and sustained antidepressant effects. Rapastinel (GLYX-13), initially described as a N-methyl-D-aspartate receptor partial glycine site a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d57f549ae8e0f9ddc7f2433ffb71465
https://doi.org/10.1093/ijnp/pyy101
https://doi.org/10.1093/ijnp/pyy101
Autor:
Roger A. Kroes, David R. Houck, Torsten M. Madsen, M. Amin Khan, Patric K. Stanton, Cassia N. Cearley, Amanda L. Gross, Jeffrey Burgdorf, Joseph R. Moskal, Xiao-Lei Zhang
Publikováno v:
International Journal of Neuropsychopharmacology
Background N-methyl-D-aspartate receptors are one member of a family of ionotropic glutamate receptors that play a pivotal role in synaptic plasticity processes associated with learning and have become attractive therapeutic targets for diseases such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34228e2791c628b5e265cbf9c21ae5c0
https://doi.org/10.1093/ijnp/pyx096
https://doi.org/10.1093/ijnp/pyx096
Autor:
Carol L. Nilsson, Roger A. Kroes
Publikováno v:
Current Neuropharmacology
Background: Depression affects over 120 million individuals of all ages and is the leading cause of disability worldwide. The lack of objective diagnostic criteria, together with the heterogeneity of the depressive disorder itself, makes it challengi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328268b9ee860b4bd12b9a891420245b
https://doi.org/10.2174/1570159x14666160309114740
https://doi.org/10.2174/1570159x14666160309114740
Autor:
Joseph R. Moskal, M. Amin Khan, John F. Disterhoft, Patric K. Stanton, Ronald M. Burch, Roger A. Kroes, Jeffrey Burgdorf
Publikováno v:
Current Neuropharmacology
Background: Rapastinel (GLYX-13) is a NMDA receptor modulator with glycine-site partial agonist properties. It is a robust cognitive enhancer and shows rapid and long-lasting antidepressant properties in both animal models and in humans. Methods: Rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1899579844538d76fe3ee477750b47e0
http://europepmc.org/articles/PMC5327451
http://europepmc.org/articles/PMC5327451
Autor:
Marina N. Asiedu, Gladys Morrison, Roger A. Kroes, Nayereh Ghoreishi-Haack, M. Scott Bowers, Cassia N. Cearley, Joseph R. Moskal, Jacqueline Ann Dunning, Jessica M. Priebe, Amanda Lynn Barth
Publikováno v:
Neurobiology of Pain
Neurobiology of Pain, Vol 7, Iss, Pp-(2020)
Neurobiology of Pain, Vol 7, Iss, Pp-(2020)
Highlights • Direct injection of the NMDAR modulator NYX-2925 in the mPFC, reverses allodynia. • Src activity is downregulated in the mPFC of a CCI neuropathic pain model. • NYX-2925 restores pain induced decrease of phosphorylated NMDAR’s.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f2fd57a0bd84aa843cf81d0e350d10
https://pubmed.ncbi.nlm.nih.gov/31909296
https://pubmed.ncbi.nlm.nih.gov/31909296
Autor:
Roger A. Kroes, Laurits Sørensen, Jeffrey Burgdorf, M. Amin Khan, Martha Hotz Vitaterna, Fred W. Turek, Torsten M. Madsen, Eun Joo Song, Christopher Olker, Joseph R. Moskal, Edward P Christian
Publikováno v:
Sleep
Study Objectives The present studies examine the effects of NMDAR activation by NYX-2925 diurnal rhythmicity of both sleep and wake as well as emotion. Methods Twenty-four-hour sleep EEG recordings were obtained in sleep-deprived and non-sleep-depriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf4215eebb02c4a6f6b4cc84a2b1de3
https://doi.org/10.1093/sleep/zsz135
https://doi.org/10.1093/sleep/zsz135