Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Roger, Strömberg"'
Publikováno v:
Molecules, Vol 29, Iss 9, p 2123 (2024)
PNAzymes are a group of artificial enzymes which show promising results in selective and efficient cleavage of RNA targets. In the present study, we introduce a series of metal chelating groups based on N,N-bis(2-picolyl) groups (parent, 6-methyl and
Externí odkaz:
https://doaj.org/article/4262e2c69d074ea8a4a3256173c9c8b6
Autor:
François Halloy, Annabelle Biscans, Katherine E. Bujold, Alexandre Debacker, Alyssa C. Hill, Aurélie Lacroix, Olivia Luige, Roger Strömberg, Linda Sundstrom, Jörg Vogel, Alice Ghidini
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 313-332 (2022)
RNA-based therapeutics are emerging as a powerful platform for the treatment of multiple diseases. Currently, the two main categories of nucleic acid therapeutics, antisense oligonucleotides and small interfering RNAs (siRNAs), achieve their therapeu
Externí odkaz:
https://doaj.org/article/cd8fb0a6285b407a8a63465d0c07a69f
Autor:
Tina Arndt, Kristaps Jaudzems, Olga Shilkova, Juanita Francis, Mathias Johansson, Peter R. Laity, Cagla Sahin, Urmimala Chatterjee, Nina Kronqvist, Edgar Barajas-Ledesma, Rakesh Kumar, Gefei Chen, Roger Strömberg, Axel Abelein, Maud Langton, Michael Landreh, Andreas Barth, Chris Holland, Jan Johansson, Anna Rising
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Recombinant spider silks are of interest but the multimodal and aggregation-prone nature of them is a limitation. Here, the authors report on a miniature spidroin based on the N-terminal domain which forms a hydrogel at 37 °C which allows for ease o
Externí odkaz:
https://doaj.org/article/797818a67a6f4d898230e24aa54af69c
Autor:
Dmytro Honcharenko, Kristina Druceikaite, Malgorzata Honcharenko, Martin Bollmark, Ulf Tedebark, Roger Strömberg
Publikováno v:
ACS Omega, Vol 6, Iss 1, Pp 579-593 (2020)
Externí odkaz:
https://doaj.org/article/539baf667f3e41209499fd3c9f068d24
Autor:
Iwona T. Myszor, Zahida Parveen, Håkan Ottosson, Peter Bergman, Birgitta Agerberth, Roger Strömberg, Gudmundur H. Gudmundsson
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract Aroylated phenylenediamines (APDs) are novel inducers of innate immunity enhancing cathelicidin gene expression in human bronchial epithelial cell lines. Here we present two newly developed APDs and aimed at defining the response and signali
Externí odkaz:
https://doaj.org/article/c34430d9332c4c8481c652a6656d4119
Autor:
Emma Kay, Rouven Stulz, Cécile Becquart, Jelena Lovric, Carolina Tängemo, Aurélien Thomen, Dženita Baždarević, Neda Najafinobar, Anders Dahlén, Anna Pielach, Julia Fernandez-Rodriguez, Roger Strömberg, Carina Ämmälä, Shalini Andersson, Michael Kurczy
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 463 (2022)
The delivery of antisense oligonucleotides (ASOs) to specific cell types via targeted endocytosis is challenging due to the low cell surface expression of target receptors and inefficient escape of ASOs from the endosomal pathway. Conjugating ASOs to
Externí odkaz:
https://doaj.org/article/0a250bb207f54135b69457a41395d273
Autor:
Kristina Karalė, Martin Bollmark, Rouven Stulz, Dmytro Honcharenko, Ulf Tedebark, Roger Strömberg
Publikováno v:
Molecules, Vol 26, Iss 22, p 6927 (2021)
2′-O-(N-(Aminoethyl)carbamoyl)methyl-modified 5-methyluridine (AECM-MeU) and 5-methylcytidine (AECM-MeC) phosphoramidites are reported for the first time and prepared in multigram quantities. The syntheses of AECM-MeU and AECM-MeC nucleosides are d
Externí odkaz:
https://doaj.org/article/567574a25e0b4173a9ab63f4adf01037
Autor:
Dmytro Honcharenko, Cristina S.J. Rocha, Karin E. Lundin, Jyotirmoy Maity, Stefan Milton, Ulf Tedebark, Merita Murtola, Malgorzata Honcharenko, Andis Slaitas, C.I. Edvard Smith, Rula Zain, Roger Strömberg
Publikováno v:
Nucleic Acid Therapeutics. 32:221-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48427b12c2d9f09ec644c260935ca69b
https://doi.org/10.1089/nat.2021.0086
https://doi.org/10.1089/nat.2021.0086
Autor:
Friederike Danneberg, Alice Ghidini, Plamena Dogandzhiyski, Elisabeth Kalden, Roger Strömberg, Michael W. Göbel
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 493-498 (2015)
Tris(2-aminobenzimidazole) conjugates with antisense oligonucleotides are effective site-specific RNA cleavers. Their mechanism of action is independent of metal ions. Here we investigate conjugates with peptide nucleic acids (PNA). RNA degradation o
Externí odkaz:
https://doaj.org/article/648a2b47cf334c29ad8f95501f7e9834
Publikováno v:
Molecules, Vol 19, Iss 3, Pp 3135-3148 (2014)
Several different approaches have been explored for conjugation of oligoethers to PNA with internally or N-terminal placed diaminopropionic acid residues. Single and double conjugation of 2-(2-(2-aminoethoxy)ethoxy)ethanol was obtained using carbonyl
Externí odkaz:
https://doaj.org/article/5f4a52430a7141368cf953f9655115b9