Systems modelling ageing : from single senescent cells to simple multi-cellular models

Autor: Martinez Guimera, Alvaro, Welsh, Ciaran, Dalle Pezze, Piero, Fullard, Nicola, Nelson, Glyn, Roger, Mathilde F., Przyborski, Stefan A., Shanley, Daryl P.

Publikováno v: Essays in biochemistry, 2017, Vol.61(3), pp.369-377 [Peer Reviewed Journal]

Systems modelling has been successfully used to investigate several key molecular mechanisms of ageing. Modelling frameworks to allow integration of models and methods to enhance confidence in models are now well established. In this article, we disc

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http://dro.dur.ac.uk/22408/1/22408.pdf

Systems modelling ageing: from single senescent cells to simple multi-cellular models.

Autor: Martinez Guimera A; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K., Welsh C; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K., Dalle Pezze P; The Babraham Institute, Babraham Campus, Cambridge, U.K., Fullard N; School of Biological and Biomedical Sciences, Durham University, Durham, U.K., Nelson G; The Bio-Imaging Unit, William Leech Building, William Leech Building, Newcastle Upon Tyne, U.K., Roger MF; School of Biological and Biomedical Sciences, Durham University, Durham, U.K., Przyborski SA; School of Biological and Biomedical Sciences, Durham University, Durham, U.K., Shanley DP; Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, Newcastle Upon Tyne, U.K. daryl.shanley@ncl.ac.uk.

Publikováno v: Essays in biochemistry [Essays Biochem] 2017 Jul 11; Vol. 61 (3), pp. 369-377. Date of Electronic Publication: 2017 Jul 11 (Print Publication: 2017).