A randomized controlled non-inferiority trial of placebo versus macrolide antibiotics for Mycoplasma pneumoniae infection in children with community-acquired pneumonia: trial protocol for the MYTHIC Study

Autor: Patrick M. Meyer Sauteur, Michelle Seiler, Romy Tilen, Ester Osuna, Margarete von Wantoch, Semjon Sidorov, Christoph Aebi, Philipp Agyeman, Florence Barbey, Julia A. Bielicki, Ludivine Coulon, Beate Deubzer, Alex Donas, Ulrich Heininger, Kristina Keitel, Henrik Köhler, Lisa Kottanattu, Roger Lauener, Anita Niederer-Loher, Klara M. Posfay-Barbe, Maren Tomaske, Noémie Wagner, Petra Zimmermann, Franziska Zucol, Stefanie von Felten, Christoph Berger

Publikováno v: Trials, Vol 25, Iss 1, Pp 1-20 (2024)

Abstract Background Mycoplasma pneumoniae is a major cause of community-acquired pneumonia (CAP) in school-aged children. Macrolides are the first-line treatment for this infection. However, it is unclear whether macrolides are effective in treating

Externí odkaz: https://doaj.org/article/eb0e92befef446dbb3aa3b6815762a10

Clinical data for paediatric research: the Swiss approach

Autor: Milenko Rakic, Manon Jaboyedoff, Sara Bachmann, Christoph Berger, Manuel Diezi, Philipp do Canto, Christopher B. Forrest, Urs Frey, Oliver Fuchs, Alain Gervaix, Amalia Stefani Gluecksberg, Michael Grotzer, Ulrich Heininger, Christian R. Kahlert, Daniela Kaiser, Matthias V. Kopp, Roger Lauener, Thomas J. Neuhaus, Paolo Paioni, Klara Posfay-Barbe, Gian Paolo Ramelli, Umberto Simeoni, Giacomo Simonetti, Christiane Sokollik, Ben D. Spycher, Claudia E. Kuehni

Publikováno v: BMC Proceedings, Vol 15, Iss S13, Pp 1-15 (2021)

Abstract Background and purpose Continuous improvement of health and healthcare system is hampered by inefficient processes of generating new evidence, particularly in the case of rare diseases and paediatrics. Currently, most evidence is generated t

Externí odkaz: https://doaj.org/article/1c527022e33744788b05b7da52c45936

Excessive Unbalanced Meat Consumption in the First Year of Life Increases Asthma Risk in the PASTURE and LUKAS2 Birth Cohorts

Autor: Alexander J. Hose, Giulia Pagani, Anne M. Karvonen, Pirkka V. Kirjavainen, Caroline Roduit, Jon Genuneit, Elisabeth Schmaußer-Hechfellner, Martin Depner, Remo Frei, Roger Lauener, Josef Riedler, Bianca Schaub, Oliver Fuchs, Erika von Mutius, Amandine Divaret-Chauveau, Juha Pekkanen, Markus J. Ege

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

A higher diversity of food items introduced in the first year of life has been inversely related to subsequent development of asthma. In the current analysis, we applied latent class analysis (LCA) to systematically assess feeding patterns and to rel

Externí odkaz: https://doaj.org/article/b72011444e634d4abeab0fde37ffdb42

Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers

Autor: Sabina Illi, Martin Depner, Petra Ina Pfefferle, Harald Renz, Caroline Roduit, Diana Hazard Taft, Karen M. Kalanetra, David A. Mills, Freda M. Farquharson, Petra Louis, Elisabeth Schmausser-Hechfellner, Amandine Divaret-Chauveau, Roger Lauener, Anne M. Karvonen, Juha Pekkanen, Pirkka V. Kirjavainen, Marjut Roponen, Josef Riedler, Michael Kabesch, Bianca Schaub, Erika von Mutius, Andreas Böck, Markus J. Ege, Remo Frei, Jon Genuneit, Lucie Laurent, Sonali Pechlivanis, Martin Täubel, Johanna Theodorou

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 205:641-650

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596158c627568fafd6ddb665255b95e2
https://doi.org/10.1164/rccm.202106-1458oc

Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma

Autor: Johanna Wohlgensinger, Eva Maria Tinner, Eckard Hamelmann, Susanne Loeliger, Yasemin Darcan-Nicolaisen, Christina Weber-Chrysochoou, Remo Frei, Roger Lauener

Publikováno v: Weber-Chrysochoou, Christina; Darcan-Nicolaisen, Yasemin; Wohlgensinger, Johanna; Tinner, Eva Maria; Frei, Remo; Loeliger, Susanne; Lauener, Roger P; Hamelmann, Eckard (2021). Chitinase-Induced Airway Hyperreactivity and Inflammation in a Mouse Model of Nonallergic Asthma. International archives of allergy and immunology, 182(7), pp. 563-570. Karger 10.1159/000513296
Int Arch Allergy Immunol

Introduction: Environmental exposure to mites and fungi has been proposed to critically contribute to the development of IgE-mediated asthma. A common denominator of such organisms is chitin. Human chitinases have been reported to be upregulated by i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccbcee6d5a60c966e6771f9cf02ec26
https://doi.org/10.1159/000513296