Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Roger, Hajjar"'
Publikováno v:
Cells, Vol 12, Iss 22, p 2660 (2023)
While it is well known that 98–99% of the human genome does not encode proteins, but are nevertheless transcriptionally active and give rise to a broad spectrum of noncoding RNAs [ncRNAs] with complex regulatory and structural functions, specific f
Externí odkaz:
https://doaj.org/article/ae6768801d8545108bcafe6cbe0c9d95
Autor:
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://doaj.org/article/7cbe5c5a5f744ee8954ab054d0919e50
Autor:
Przemek A. Gorski, Ahyoung Lee, Philyoung Lee, Jae Gyun Oh, Peter Vangheluwe, Kiyotake Ishikawa, Roger Hajjar, Changwon Kho
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3502 (2023)
Impaired calcium uptake resulting from reduced expression and activity of the cardiac sarco-endoplasmic reticulum Ca2+ ATPase (SERCA2a) is a hallmark of heart failure (HF). Recently, new mechanisms of SERCA2a regulation, including post-translational
Externí odkaz:
https://doaj.org/article/5466c28c47fb49998dc53e7c0a842f35
Autor:
Jozef Bartunek, Andre Terzic, Beth A. Davison, Atta Behfar, Ricardo Sanz‐Ruiz, Wojciech Wojakowski, Warren Sherman, Guy R. Heyndrickx, Marco Metra, Gerasimos S. Filippatos, Scott A. Waldman, John R. Teerlink, Timothy D. Henry, Bernard J. Gersh, Roger Hajjar, Michal Tendera, Stefanie Senger, Gad Cotter, Thomas J. Povsic, William Wijns, for the CHART Program
Publikováno v:
ESC Heart Failure, Vol 7, Iss 6, Pp 3345-3354 (2020)
Abstract Aims This study aims to explore long‐term clinical outcomes of cardiopoiesis‐guided stem cell therapy for ischaemic heart failure assessed in the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART‐1) trial. Methods and
Externí odkaz:
https://doaj.org/article/ade29cdc81994f4b9daed20367d13bfe
Autor:
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Żak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Publikováno v:
Advanced Science, Vol 8, Iss 10, Pp n/a-n/a (2021)
Abstract Heart failure (HF) remains a major cause of morbidity and mortality worldwide. One of the risk factors for HF is cardiac hypertrophy (CH), which is frequently accompanied by cardiac fibrosis (CF). CH and CF are controlled by master regulator
Externí odkaz:
https://doaj.org/article/a2a9c69f223b435589f033b9a95946b8
Autor:
Katherine C. Michelis, Aya Nomura-Kitabayashi, Laura Lecce, Oscar Franzén, Simon Koplev, Yang Xu, Maria Paola Santini, Valentina D'Escamard, Jonathan T.L. Lee, Valentin Fuster, Roger Hajjar, Ramachandra C. Reddy, Joanna Chikwe, Paul Stelzer, Farzan Filsoufi, Allan Stewart, Anelechi Anyanwu, Johan L.M. Björkegren, Jason C. Kovacic
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 242-257 (2018)
Summary: Mesenchymal stem cells (MSCs) reportedly exist in a vascular niche occupying the outer adventitial layer. However, these cells have not been well characterized in vivo in medium- and large-sized arteries in humans, and their potential pathol
Externí odkaz:
https://doaj.org/article/1f2349ca0d1348c4bbc264d6b3932a36
Autor:
Solene M. Evrard, Laura Lecce, Katherine C. Michelis, Aya Nomura-Kitabayashi, Gaurav Pandey, K-Raman Purushothaman, Valentina d’Escamard, Jennifer R. Li, Lahouaria Hadri, Kenji Fujitani, Pedro R. Moreno, Ludovic Benard, Pauline Rimmele, Ariella Cohain, Brigham Mecham, Gwendalyn J. Randolph, Elizabeth G. Nabel, Roger Hajjar, Valentin Fuster, Manfred Boehm, Jason C. Kovacic
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Endothelial to mesenchymal transition (EndMT) is a crucial developmental process that also plays a role in the pathogenesis of some diseases. Here the authors show that EndMT contributes to the development of atherosclerosis in mice and humans, and i
Externí odkaz:
https://doaj.org/article/a0cca03eebdd4de2a5b3919ef6865a76
Autor:
Alice Main, Andri Bogusalvskyii, Jacqueline Howie, Chien-wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70822cf6eb2faffd02fabc5cc956e698
https://doi.org/10.1101/2022.08.19.504400
https://doi.org/10.1101/2022.08.19.504400
Autor:
Maria Giovanna Trivieri, Francesca Stillitano, Delaine Ceholski, Irene Turnbull, Kevin Costa, Thomas Weber, Kenneth Fish, Evangelia Kranias, Roger Hajjar
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 26-26 (2019)
OBJECTIVES/SPECIFIC AIMS: To study the biology of Phosholamban (PLN) in a human relevant model. METHODS/STUDY POPULATION: State of the art stem-cell technologies using iPSC-CMs derived from carriers of a lethal PLN mutation. RESULTS/ANTICIPATED RESUL
Externí odkaz:
https://doaj.org/article/add6508bc87d453fa71a94fb3a120355
Autor:
Bracy, Fertig, Jiayue, Ling, Edgar E, Nollet, Sara, Dobi, Tara, Busiau, Kiyotake, Ishikawa, Kelly, Yamada, Ahyoung, Lee, Changwon, Kho, Lauren, Wills, Amy J, Tibbo, Mark, Scott, Kirsten, Grant, Kenneth S, Campbell, Emma J, Birks, Niall, MacQuaide, Roger, Hajjar, Godfrey L, Smith, Jolanda, van der Velden, George S, Baillie
Publikováno v:
The FEBS journal. 289(20)
Post-translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin I can also