Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Roger, Geiger"'
Autor:
Alessia Cacciatore, Dheeraj Shinde, Carola Musumeci, Giada Sandrini, Luca Guarrera, Domenico Albino, Gianluca Civenni, Elisa Storelli, Simone Mosole, Elisa Federici, Alessio Fusina, Marta Iozzo, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Marco Bolis, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-in
Externí odkaz:
https://doaj.org/article/724f72ec506f4c06aa1670dd1c8ab69a
Autor:
Ole Kristian Greiner-Tollersrud, Máté Krausz, Vincent Boehler, Aikaterini Polyzou, Maximilian Seidl, Ambra Spahiu, Zeinab Abdullah, Katarzyna Andryka-Cegielski, Felix Immunuel Dominick, Katrin Huebscher, Andreas Goschin, Cristian R. Smulski, Eirini Trompouki, Regina Link, Hilmar Ebersbach, Honnappa Srinivas, Martine Marchant, Georgios Sogkas, Dieter Staab, Cathrine Vågbø, Danilo Guerini, Sebastian Baasch, Eicke Latz, Gunther Hartmann, Philippe Henneke, Roger Geiger, Xiao P. Peng, Bodo Grimbacher, Eva Bartok, Ingrun Alseth, Max Warncke, Michele Proietti
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114899- (2024)
Summary: Although adenosine deaminase 2 (ADA2) is considered an extracellular ADA, evidence questions the physiological relevance of this activity. Our study reveals that ADA2 localizes within the lysosomes, where it is targeted through modifications
Externí odkaz:
https://doaj.org/article/f6e14d70f0b648c3aca83261512b83d8
Autor:
Adrien Krug, Marie Tosolini, Blandine Madji Hounoum, Jean-Jacques Fournié, Roger Geiger, Matteo Pecoraro, Patrick Emond, Philippe Gaulard, François Lemonnier, Jean-Ehrland Ricci, Els Verhoeyen
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-20 (2024)
Abstract Background Angioimmunoblastic T-cell lymphoma (AITL) is a malignancy with very poor survival outcome, in urgent need of more specific therapeutic strategies. The drivers of malignancy in this disease are CD4+ follicular helper T cells (Tfh).
Externí odkaz:
https://doaj.org/article/0685f8cd030f49b99d2ba6536610e7de
Autor:
Veronica Lisi, Giorgia Senesi, Nadia Bertola, Matteo Pecoraro, Sara Bolis, Alice Gualerzi, Silvia Picciolini, Andrea Raimondi, Cristina Fantini, Elisa Moretti, Attilio Parisi, Paolo Sgrò, Luigi Di Luigi, Roger Geiger, Silvia Ravera, Giuseppe Vassalli, Daniela Caporossi, Carolina Balbi
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102737- (2023)
Cardiovascular diseases (CVD) can cause various conditions, including an increase in reactive oxygen species (ROS) levels that can decrease nitric oxide (NO) availability and promote vasoconstriction, leading to arterial hypertension. Physical exerci
Externí odkaz:
https://doaj.org/article/7f7bb08e816a44dc8dfadccd04c7ffbd
Autor:
Neftali Ramirez, Sara Posadas-Cantera, Niko Langer, Andres Caballero Garcia de Oteyza, Michele Proietti, Baerbel Keller, Fangwen Zhao, Victoria Gernedl, Matteo Pecoraro, Hermann Eibel, Klaus Warnatz, Esteban Ballestar, Roger Geiger, Claudia Bossen, Bodo Grimbacher
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary immunodeficiency in humans. The genetic cause of CVID is still unknown in about 70% of cases. Ten percent of CVID patients carry heterozygous mutations in the t
Externí odkaz:
https://doaj.org/article/e078849fb5c941cdb5ce9e894452f9de
Autor:
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render pros
Externí odkaz:
https://doaj.org/article/f2c4c2cbe140413794b564af2e6c8775
Autor:
Ning Li, Fernando Canale, Camilla Basso, Anna Sokolovska, Michela Perotti, Michael James, Wenjie Jin, Jean-Philippe Theurillat, Daniel Leventhal, Kip West, Jose Lora, Federica Sallusto, Roger Geiger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/a0be3067cdbb4c43b08fc905e02ccd77
Autor:
Roger Geiger
Publikováno v:
Higher Education Quarterly. 76:907-910
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d2c0504ebde8845f04c0bbaef84a7ad
https://doi.org/10.1111/hequ.12393
https://doi.org/10.1111/hequ.12393
Autor:
Hanif J. Khameneh, Nicolas Fonta, Alessandro Zenobi, Charlène Niogret, Pedro Ventura, Concetta Guerra, Ivo Kwee, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Andrea Cavalli, Francesco Bertoni, Eric Vivier, Andreas Trumpp, Greta Guarda
SummaryMyc is a pleiotropic transcription factor involved in cancer, cell proliferation, and metabolism. Its regulation and function in Natural Killer (NK) cells, which are innate cytotoxic lymphocytes important to control viral infections and cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7979611701164d9da6e3675361b6d2b
https://doi.org/10.1101/2022.12.20.521160
https://doi.org/10.1101/2022.12.20.521160
Autor:
Nadezhda Camacho-Ordonez, Neftali Ramirez, Sara Posadas-Cantera, Andrés Caballero-Oyteza, Manfred Fliegauf, Fangwen Zhao, Maria Guarini, Victoria Gernedl, Mateo Pecoroaro, Klaus Warnatz, Christoph Bock, Esteban Ballestar, Roger Geiger, Michele Proietti, Bodo Grimbacher
The transcription factor NF-κB plays a pivotal role in the adaptive immune response. Pathogenic variants inNFKB1are the most common genetic etiology of common variable immunodeficiency (CVID). Patients frequently present with impaired terminal B cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae8187c93dc15eaa464fbd6ef83a941
https://doi.org/10.1101/2022.11.22.517350
https://doi.org/10.1101/2022.11.22.517350