Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Rogelio P. Frutos"'
Autor:
Yanchao Xin, Frank Roschangar, Zeena Williams, Denis Byrne, Dmitry Kurouski, Jason A. Mulder, Jinhua J. Song, Alice T. Granger, Laurence J. Nummy, Jon C. Lorenz, Scott Pennino, Frederic G. Buono, Chris H. Senanayake, Yaping Hong, Ajith Premasiri, Nathan K. Yee, Joe Gao, Sonia Rodriguez, Xinzhu Zhang, Bo Qu, Jack D. Brown, Rogelio P. Frutos, Bikshandarkoil A. Narayanan, Zhantong Mao, Azad Hossain, Ning Li, Mariusz Krawiec, Heewon Lee, Yongda Zhang, Zhengxu S. Han, Nizar Haddad, Zhibin Li, Yibo Xu, Nelu Grinberg, Joshua D. Sieber, Carl A. Busacca
Publikováno v:
The Journal of Organic Chemistry. 83:1448-1461
A chromatography-free, asymmetric synthesis of the C2-symmetric P-chiral diphosphine t-Bu-SMS-Phos was developed using a chiral auxiliary-based approach in five steps from the chiral auxiliary in 36% overall yield. Separtion and recovery of the auxil
Autor:
Sonia Rodriguez, Jason A. Mulder, Chris H. Senanayake, Bing-Shiou Yang, Tampone Thomas G, Nathan K. Yee, Rogelio P. Frutos
Publikováno v:
Organic Process Research & Development. 20:982-988
A practical, safe, and efficient process for the synthesis of PDE4 (phosphodiesterase type 4) inhibitors represented by 1 and 2 was developed and demonstrated on a multi-kilogram scale. Key aspects of the process include the regioselective synthesis
Autor:
Sonia Rodriguez, Diana C. Reeves, Rogelio P. Frutos, Nitinchandra D. Patel, Tampone Thomas G, Chris H. Senanayake
Publikováno v:
Asian Journal of Organic Chemistry. 3:769-772
A practical, safe, and efficient synthesis of anti-inflammatory cytokine inhibitors was developed and implemented for a number of analogues. A key aspect of the process is an efficient, one-pot, tandem copper-catalyzed azidonation and Huisgen 1,3-dip
Autor:
Bo Qu, Jason A. Mulder, Max Sarvestani, Rogelio P. Frutos, Nizar Haddad, Jinhua J. Song, Tampone Thomas G, Magnus C. Eriksson, Nitinchandra D. Patel, Sherry Shen, Xiufeng Sun, Joe Gao, Chris H. Senanayake
Publikováno v:
Organic Process Research & Development. 17:940-945
Reported herein is a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in the synthesis of novel anti-infective agents. The key to this process is the trifluoromethylation of an aryl iodide using an inexp
Autor:
Xiao-Jun Wang, Lawrence J. Nummy, Yibo Xu, Thomas Nicola, Dhileep Krishnamurthy, Xiufeng Sun, Carl A. Busacca, Chris H. Senanayake, Li Zhang, Thomas Wirth, Nathan K. Yee, Rogelio P. Frutos
Publikováno v:
Organic Process Research & Development. 15:1185-1191
The synthesis of LFA-1 inhibitor BIRT2584 on metric-ton scale was accomplished by means of a safe and robust process. Highlights of the process include the asymmetric synthesis of the key advanced intermediate by implementation of Seebach’s self-re
Autor:
Lana Louise Smith-Keenan, Paul Kreye, Wendelin Samstag, Thomas Nicola, Victor Fuchs, XuWu Feng, Jinghua Xu, Jana Vitous, Earl Spinelli, Rogelio P. Frutos, Jonathan Tan, Eric Winter, Robert D. Simpson, Li Zhang, Fabrice Gallou, Michael D. Ridges, Nathan K. Yee, Vittorio Farina, Marvin Johnson, Xiao-Jun Wang, Nizar Haddad, Ioannis N. Houpis, Xudong Wei, Michael Brenner, Kai Donsbach, Yibo Xu
Publikováno v:
The Journal of Organic Chemistry. 71:7133-7145
A multistep scalable synthesis of the clinically important hepatitis C virus (HCV) protease inhibitor BILN 2061 (1) is described. The synthesis is highly convergent and consists of two amide bond formations, one etherification, and one ring-closing m
Autor:
Bruno Haché, Vittorio Farina, Marvin Johnson, Pierre L. Beaulieu, Christian Brochu, Lana Louise Smith-Keenan, Nathan K. Yee, Jean-Simon Duceppe, Rogelio P. Frutos, Victor Fuchs, Anne-Marie Faucher, Nizar Haddad, Ioannis N. Houpis
Publikováno v:
Synthesis. 2006:2563-2567
Herein we describe the development of an efficient, safe and practical process for the synthesis of 7-methoxy-2-(2-amino-4-thiazolyl)quinoline. Our new process allowed for a more convergent approach and eliminates the use of potentially dangerous rea
Autor:
Yibo Xu, Diana C. Reeves, Dhileepkumar Krishnamurthy, Isabelle Gallou, Rogelio P. Frutos, Chris H. Senanayake
Publikováno v:
Tetrahedron Letters. 46:8369-8372
Expedient and practical new methodology for the synthesis of substituted imidazoles was developed to provide a rapid access to a variety of 2-substituted, 1,2-disubstituted and 1,2,4-trisubstituted imidazoles by the direct CuCl-mediated reaction of n
Autor:
Yibo Xu, Chung Jinchin, Xiao-Jun Wang, Denis Byrne, Chris H. Senanayake, Sherry Shen, Laurence J. Nummy, Varsolona Richard J, Li Zhang, Dhileepkumar Krishnamurthy, Vittorio Farina, Rogelio P. Frutos
Publikováno v:
Tetrahedron Letters. 46:273-276
An efficient and chromatography-free approach for synthesis of a new class of LFA-1 inhibitors was developed. A copper(I) chloride-promoted intramolecular cyclization of thiohydantoins 7a–b serves as a key step to highly functionalized bicyclic gua
Autor:
Laurence J. Nummy, Rogelio P. Frutos, Elio Napolitano, Denis Byrne, Jinhua J. Song, Nathan K. Yee, Vittorio Farina, Paul-James Jones
Publikováno v:
Tetrahedron: Asymmetry. 14:3495-3501
An efficient enantiospecific synthesis of the cell adhesion inhibitor BIRT-377 by self-regeneration of stereocenters has been achieved in 38% overall yield in eight steps. The key transformations involve the stereoselective formation of the trans imi