Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rogan A. Grant"'
Autor:
Michaela M. Novakovic, Kirill S. Korshunov, Rogan A. Grant, Megan E. Martin, Hiam A. Valencia, G. R. Scott Budinger, Jelena Radulovic, Murali Prakriya
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Astrocytes contribute to brain inflammation in neurological disorders but the molecular mechanisms controlling astrocyte reactivity and their relationship to neuroinflammatory endpoints are complex and poorly understood. In this study, we as
Externí odkaz:
https://doaj.org/article/126b49e946bc446587919a74f95203cf
Autor:
Catherine A. Gao, Nikolay S. Markov, Thomas Stoeger, Anna Pawlowski, Mengjia Kang, Prasanth Nannapaneni, Rogan A. Grant, Chiagozie Pickens, James M. Walter, Jacqueline M. Kruser, Luke Rasmussen, Daniel Schneider, Justin Starren, Helen K. Donnelly, Alvaro Donayre, Yuan Luo, G.R. Scott Budinger, Richard G. Wunderink, Alexander V. Misharin, Benjamin D. Singer, The NU SCRIPT Study Investigators
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
BACKGROUND Despite guidelines promoting the prevention and aggressive treatment of ventilator-associated pneumonia (VAP), the importance of VAP as a driver of outcomes in mechanically ventilated patients, including patients with severe COVID-19, rema
Externí odkaz:
https://doaj.org/article/f2a85cfc68d846f1a4d5f04bb23bd1d4
Autor:
Ian Casci, Karthik Krishnamurthy, Sukhleen Kour, Vadreenath Tripathy, Nandini Ramesh, Eric N. Anderson, Lara Marrone, Rogan A. Grant, Stacie Oliver, Lauren Gochenaur, Krishani Patel, Jared Sterneckert, Amanda M. Gleixner, Christopher J. Donnelly, Marc-David Ruepp, Antonella M. Sini, Emanuela Zuccaro, Maria Pennuto, Piera Pasinelli, Udai Bhan Pandey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
The exact molecular mechanisms driving FUS-mediated toxicity remain unclear. Here, the authors demonstrate that muscleblind (Mbl) is a novel modifier of FUS-associated ALS, with knockdown of endogenous Mbl suppressing neuromuscular junction defects a
Externí odkaz:
https://doaj.org/article/808f528e987e4f6fbf0a7d25207ff6ed
Autor:
Avni A. Bavishi, MD, MS, Ruben J. Mylvaganam, MD, Rishi Agarwal, MD, Ryan J. Avery, MD, Michael J. Cuttica, MD, For the NU COVID Investigators, A. Christine Argento, Ajay A. Wagh, Alexander V. Misharin, Alexandra C. McQuattie-Pimentel, Alexis Rose Wolfe, Alvaro Donayre, Ankit Bharat, Anna E. Pawlowski, Anne R. Levenson, Anthony M. Joudi, Benjamin D. Singer, Betty Tran, Catherine A. Gao, Chao Qi, Chiagozie O. Pickens, Chitaru Kurihara, Clara J. Schroedl, Daniel Meza, Daniel Schneider, David A. Kidd, David D. Odell, David W. Kamp, Elizabeth S. Malsin, Emily M. Leibenguth, Eric P. Cantey, Gabrielle Y. Liu, G. R. Scott Budinger, Helen K. Donnelly, Isaac A. Goldberg, Jacob I. Sznajder, Jacqueline M. Kruser, James M. Walter, Jane E. Dematte, Jason M. Arnold, John Coleman, Joseph I. Bailey, Joseph S. Deters, Justin A. Fiala, Katharine Secunda, Kaitlyn Vitale, Khalilah L. Gates, Kristy Todd, Lindsey D. Gradone, Lindsey N. Textor, Lisa F. Wolfe, Lorenzo L. Pesce, Luisa Morales-Nebreda, Madeline L. Rosenbaum, Manu Jain, Marc A. Sala, Mary Carns, Marysa V. Leya, Mengjia Kang, Michael J. Alexander, Michael J. Cuttica, Michelle Hinsch Prickett, Natalie Jensema, Nicole Borkowski, Nikolay S. Markov, Orlyn R. Rivas, Paul A. Reyfman, Peter H. S. Sporn, Prasanth Nannapaneni, Rachel B. Kadar, Rachel M. Kaplan, Rade Tomic, Radhika Patel, Rafael Garza-Castillon, Ravi Kalhan, Richard G. Wunderink, Rogan A. Grant, Romy Lawrence, Ruben J. Mylvaganam, Samuel S. Kim, Sanket Thakkar, Sean B. Smith, SeungHye Han, Sharon R. Rosenberg, Susan R. Russell, Sydney M. Hyder, Taylor A. Poor, Theresa A. Lombardo, Zasu M. Klug
Publikováno v:
Critical Care Explorations, Vol 3, Iss 5, p e0415 (2021)
Objectives:. Determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course. Design:. Retrospective cohort study. Setting:. Northwestern Memorial Hosp
Externí odkaz:
https://doaj.org/article/a5ecd5f3973e465d9c9346646dbe1a1d
Autor:
Alice Migazzi, Chiara Scaramuzzino, Eric N. Anderson, Debasmita Tripathy, Ivó H. Hernández, Rogan A. Grant, Michela Roccuzzo, Laura Tosatto, Amandine Virlogeux, Chiara Zuccato, Andrea Caricasole, Tamara Ratovitski, Christopher A. Ross, Udai B. Pandey, José J. Lucas, Frédéric Saudou, Maria Pennuto, Manuela Basso
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108980- (2021)
Summary: The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disru
Externí odkaz:
https://doaj.org/article/4ec24cea628a418d9972d9f2b7afcdb5
Autor:
Thomas Stoeger, Rogan A. Grant, Alexandra C. McQuattie-Pimentel, Kishore R. Anekalla, Sophia S. Liu, Heliodoro Tejedor-Navarro, Benjamin D. Singer, Hiam Abdala-Valencia, Michael Schwake, Marie-Pier Tetreault, Harris Perlman, William E. Balch, Navdeep S. Chandel, Karen M. Ridge, Jacob I. Sznajder, Richard I. Morimoto, Alexander V. Misharin, G. R. Scott Budinger, Luis A. Nunes Amaral
Publikováno v:
Nature Aging. 2:1191-1206
Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data from multiple studies. Here, we show that transcript length alone explai
Autor:
Ambre J. Sala, Rogan A. Grant, Ghania Imran, Claire Morton, Renee M. Brielmann, Laura C. Bott, Jennifer Watts, Richard I. Morimoto
The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence organismal stress resilience inC. elegan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb8aaa76c9f520b2b940b5c37c40346
https://doi.org/10.1101/2023.04.25.537803
https://doi.org/10.1101/2023.04.25.537803
Autor:
Laura A. Dada, A. Weng, Satoshi Watanabe, Annette S. Flozak, Monique Hinchcliff, Rogan A. Grant, M. Maciel-Herrerias, G.S. Budinger, Lynn C. Welch, Raul Piseaux Aillon, SeungHye Han, Cara J. Gottardi, Alexander V. Misharin
Publikováno v:
American journal of respiratory cell and molecular biology. 66(5)
Epithelial polyploidization post-injury is a conserved phenomenon, recently shown to improve barrier restoration during wound healing. Whether lung injury can induce alveolar epithelial polyploidy is not known. We show that bleomycin injury induces A
Autor:
Chiagozie O. Pickens, Catherine A. Gao, Michael J. Cuttica, Sean B. Smith, Lorenzo L. Pesce, Rogan A. Grant, Mengjia Kang, Luisa Morales-Nebreda, Avni A. Bavishi, Jason M. Arnold, Anna Pawlowski, Chao Qi, G. R. Scott Budinger, Benjamin D. Singer, Richard G. Wunderink, A. Christine Argento, Ajay A. Wagh, Alexander V. Misharin, Alexandra C. McQuattie-Pimentel, Alexis Rose Wolfe, Alvaro Donayre, Ankit Bharat, Anne R. Levenson, Anthony M. Joudi, Betty Tran, Chitaru Kurihara, Clara J Schroedl, Daniel Meza, Daniel Schneider, David A. Kidd, David D. Odell, David W. Kamp, Elizabeth S. Malsin, Emily M. Leibenguth, Eric P. Cantey, Gabrielle Y. Liu, Helen K. Donnelly, Isaac A. Goldberg, Jacob I. Sznajder, Jacqueline M. Kruser, James M. Walter, Jane E. Dematte, John Coleman, Joseph I. Bailey, Joseph S. Deters, Justin A. Fiala, Katharine Secunda, Kaitlyn Vitale, Khalilah L. Gates, Kristy Todd, Lindsey D. Gradone, Lindsey N. Textor, Lisa F. Wolfe, Madeline L. Rosenbaum, Manu Jain, Marc A. Sala, Mary Carns, Marysa V. Leya, Michael J. Alexander, Michelle Hinsch Prickett, Natalie Jensema, Nicole Borkowski, Nikolay S. Markov, Orlyn R. Rivas, Paul A. Reyfman, Peter H. S. Sporn, Prasanth Nannapaneni, Rachel B. Kadar, Rachel M. Kaplan, Rade Tomic, Radhika Patel, Rafael Garza-Castillon, Ravi Kalhan, Romy Lawrence, Ruben J. Mylvaganam, Samuel S. Kim, Sanket Thakkar, SeungHye Han, Sharon R. Rosenberg, Susan R. Russell, Sydney M. Hyder, Taylor A. Poor, Theresa A. Lombardo, Zasu M. Klug
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Current guidelines recommend patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia receive empirical antibiotics for suspected bacterial superinfection on the basis of weak evidence. Rates of ventilator-assoc
Autor:
Matthew J. Yousefzadeh, Dudley W. Lamming, Mariana M Herrerias, Heidi H. Pak, Cara L Green, Hua Bai, Josef P. Clark, Srijit Das, Peiduo Liu, Davis A. Englund, Daniella E. Chusyd, Veena Prahlad, Rogan A. Grant
Publikováno v:
J Gerontol A Biol Sci Med Sci
While the average human life span continues to increase, there is little evidence that this is leading to a contemporaneous increase in “healthy years” experienced by our aging population. Consequently, many scientists focus their research on und