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Akademický článek

Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers

Autor: Fox GM, Roffel AF, Hartstra J, Bussian LA, van Marle SP

Publikováno v: Clinical Pharmacology: Advances and Applications, Vol Volume 11, Pp 161-169 (2019)

Gabriel M Fox,1 Ad F Roffel,2 Jan Hartstra,2 Linda A Bussian,3 Sjoerd P van Marle2 1Department of Clinical Development, Acacia Pharma Ltd, Cambridge, UK; 2PRA Health Sciences, Groningen, the Netherlands; 3Comedica Ltd, Cambridge, UKCorrespondence: Ga

Externí odkaz: https://doaj.org/article/a67dd663b38743ce866a2a52a7bc1a3c

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Effects of fenoterol on beta-adrenoceptor and muscarinic M-2 receptor function in bovine tracheal smooth muscle

Autor: De Vries, B, Roffel, AF, Kooistra, JM, Meurs, H, Zaagsma, J

Publikováno v: European Journal of Pharmacology, 419(2-3), 253-259. ELSEVIER SCIENCE BV

Prolonged (18 h) incubation of isolated bovine tracheal smooth muscle with the beta (2)-adrenoceptor agonist fenoterol (10 muM) induced desensitization of isoprenaline-induced adenylyl cyclase activity in bovine tracheal smooth muscle membranes, char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e38b742689de782cea62e4c4b5ac4d65
https://research.rug.nl/en/publications/91b6c3e5-2d5b-4853-9739-93be1dfb6c19

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beta-agonist-induced constitutive beta(2)-adrenergic receptor activity in bovine tracheal smooth muscle

Autor: de Vries, B, Meurs, H, Roffel, AF, Elzinga, CRS, Hoiting, BH, de Vries, MML, Zaagsma, J

Publikováno v: British Journal of Pharmacology, 131(5), 915-920. Wiley-Blackwell

1 According to the two state receptor model, the beta (2)-adrenergic receptor (beta (2)-AR) isomerizes between an inactive state and a constitutively active state, which couples to the stimulatory G-protein in the absence of agonist. In bovine trache

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::24973e96921336ac52ddf2eef84cfe53
https://research.rug.nl/en/publications/ddc20f76-8682-47d0-b1f7-f32398d33b17

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Periodical

Metabolism and excretion of GCC-4401C, a factor Xa inhibitor, in humans

Autor: Roffel, AF, Marle, SP van, Choi, S, Lee, HJ, Dueker, SR, Tiessen, RG

Publikováno v: International Journal of Pharmacokinetics; May 2017, Vol. 2 Issue: 2 p93-104, 12p

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POSITIVE COOPERATIVE INTERACTION OF QUATERNARY ANTICHOLINERGICS WITH FUNCTIONAL MUSCARINIC RECEPTORS IN BOVINE TRACHEAL SMOOTH-MUSCLE

Autor: ROFFEL, AF, ELZINGA, CRS, BELTMAN, W, VANTINTELEN, EJJ, ZAAGSMA, J

Publikováno v: Naunyn-Schmiedebergs Archives of Pharmacology, 343(3), 252-259. SPRINGER

The interaction of quaternary anticholinergics with muscarinic receptors in bovine tracheal smooth muscle strips was investigated because some of these compounds have shown anomalous (biphasic) behaviour in radioligand displacement studies, in contra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::95102e4d234c86d779fd35718aabb61d
https://research.rug.nl/en/publications/556a91aa-e7dc-4b1a-b932-97e7c1f8682a

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HETEROGENEOUS RECEPTOR-BINDING OF CLASSICAL QUATERNARY MUSCARINIC ANTAGONISTS .2. MODULATION IN BOVINE BRAIN

Autor: ROFFEL, AF, ENSING, K, ELZINGA, CRS, INTHOUT, WG, VANTINTELEN, EJJ, DEZEEUW, RA, ZAAGSMA, J

Publikováno v: Archives internationales de pharmacodynamie et de therapie, 314, 105-121

The heterogeneous binding behavior exhibited by classical quaternary muscarinic antagonists was further investigated in order to establish possible molecular and/or environmental differences between the high (Q1) and low (Q2) affinity binding sites.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::aecc6300a0d965eff8d939fe87f077e1
https://research.rug.nl/en/publications/b843e795-7a8c-489c-9118-eb5b70dac918

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