Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Rofaida Salem"'
1
Akademický článek
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
Autor: Moataz A. Shaldam, Hadia Almahli, Andrea Angeli, Rehab Mustafa Badi, Eman F. Khaleel, Abdelrahman I. Zain-Alabdeen, Zainab M. Elsayed, Eslam B. Elkaeed, Rofaida Salem, Claudiu T. Supuran, Wagdy M. Eldehna, Haytham O. Tawfik
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor a
Externí odkaz: https://doaj.org/article/a573ab6ca22e465f839233e88660bc72
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2
Akademický článek
Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity
Autor: Haytham O. Tawfik, Moataz A. Shaldam, Alessio Nocentini, Rofaida Salem, Hadia Almahli, Sara T. Al-Rashood, Claudiu T. Supuran, Wagdy M. Eldehna
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 1043-1052 (2022)
Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological processes and are expressed in both normal and cancerous cells. Thus, non-isoform selective inhib
Externí odkaz: https://doaj.org/article/79d3c232bc97466189f429543e2d6368
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3
Akademický článek
Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer
Autor: Wagdy M. Eldehna, Rofaida Salem, Zainab M. Elsayed, Tarfah Al-Warhi, Hamada R. Knany, Rezk R. Ayyad, Thamer Bin Traiki, Maha-Hamadien Abdulla, Rehan Ahmad, Hatem A. Abdel-Aziz, Radwan El-Haggar
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1423-1434 (2021)
In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a–e and 7a–i) was designed and synthesised. The anticancer activity for compounds (5b–d, 7a, 7b, 7d and 7g) was measured against NCI-55 human cancer cell lin
Externí odkaz: https://doaj.org/article/3772b97f90654613a38cd0678b5d84ab
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4
Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer
Autor: Rofaida Salem, Maha-Hamadien Abdulla, Zainab M. Elsayed, Thamer Bin Traiki, Rezk R. Ayyad, Rehan Ahmad, Tarfah Al-Warhi, Wagdy M. Eldehna, Hamada R. Knany, Radwan El-Haggar, Hatem A. Abdel-Aziz
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1423-1434 (2021)
In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a–e and 7a–i) was designed and synthesised. The anticancer activity for compounds (5b–d, 7a, 7b, 7d and 7g) was measured against NCI-55 human cancer cell lin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1341e7998e433455b91c3bda60613df
http://europepmc.org/articles/PMC8245078
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6
Predictive retention study of β-blockers in different chromatographic systems as potential tool for lipophilicity screening based on QSRR approach
Autor: Ahmed F. Abdel Hakiem, Ahmed S. Aboraia, Al Montaser Bellah H. Ali, Rofaida Salem, Ahmed Kamal
Publikováno v: Journal of Liquid Chromatography & Related Technologies. 44:12-24
The chromatographic analysis of a number of β-blockers on different thin-layer chromatography (TLC) systems was carried out. The analysis was done on three different systems, namely normal phase, p...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8213d1e1b519ca17bc22bb95ac70fa05
https://doi.org/10.1080/10826076.2020.1859384
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7
Identification of novel piperazine-tethered phthalazines as selective CDK1 inhibitors endowed with in vitro anticancer activity toward the pancreatic cancer
Autor: Laila Akl, Amer Ali Abd El-Hafeez, Tamer M. Ibrahim, Rofaida Salem, Hala Mohamed M. Marzouk, Ramadan A. El-Domany, Pradipta Ghosh, Wagdy M. Eldehna, Sahar M. Abou-Seri
Publikováno v: European Journal of Medicinal Chemistry. 243:114704
Pharmacologic inhibition of the oncogenic protein kinases using small molecules is a promising strategy to combat several human malignancies. CDK1 is an example of such a valuable target for the management of pancreatic ductal adenocarcinomas (PDAC);
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405d813cc19206ea60e5bacb42c71ad9
https://doi.org/10.1016/j.ejmech.2022.114704
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8
Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors
Autor: Alessandro Bonardi, Claudiu T. Supuran, Rofaida Salem, Diaaeldin M. Elimam, Heba Abdelrasheed Allam, Sara T. Al-Rashood, Alessio Nocentini, Mahmoud M. Elaasser, Wagdy M. Eldehna, Paola Gratteri
Publikováno v: European journal of medicinal chemistry. 228
Ligustrazine is the principle bioactive alkaloid in the widely-used Chinese herb Chuan Xiong rhizome. Herein, a series of novel derivatives has been designed as human carbonic anhydrases inhibitors (hCAIs) starting from the natural product Ligustrazi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d522936a37021e64175c19a014aa0c
https://pubmed.ncbi.nlm.nih.gov/34871842
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9
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors
Autor: Ramadan A. El-Domany, Wagdy M. Eldehna, Tamer M. Ibrahim, Clemente Capasso, Moataz A. Shaldam, Rofaida Salem, Alessio Nocentini, Claudiu T. Supuran, Hatem A. Abdel-Aziz, Zainab M. Elsayed
Publikováno v: European journal of medicinal chemistry 216 (2021). doi:10.1016/j.ejmech.2021.113283
info:cnr-pdr/source/autori:Shaldam M.; Eldehna W.M.; Nocentini A.; Elsayed Z.M.; Ibrahim T.M.; Salem R.; El-Domany R.A.; Capasso C.; Abdel-Aziz H.A.; Supuran C.T./titolo:Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors/doi:10.1016%2Fj.ejmech.2021.113283/rivista:European journal of medicinal chemistry/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:216
In the present study, we describe the design of different series of benzofuran-based derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based on bioisosteric replacement for the p-fluorophenyl SLC-0111 tail with the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3670b871cbc43eeb421fd1236fb46763
http://www.cnr.it/prodotto/i/450304
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10
Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors
Autor: Tamer M. Ibrahim, Moataz A. Shaldam, Zainab M. Elsayed, Ramadan A. El-Domany, Clemente Capasso, Alessio Nocentini, Wagdy M. Eldehna, Claudiu T. Supuran, Rofaida Salem
Publikováno v: International journal of molecular sciences
22 (2021). doi:10.3390/ijms222011119
info:cnr-pdr/source/autori:Shaldam M.; Nocentini A.; Elsayed Z.M.; Ibrahim T.M.; Salem R.; El-Domany R.A.; Capasso C.; Supuran C.T.; Eldehna W.M./titolo:Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors/doi:10.3390%2Fijms222011119/rivista:International journal of molecular sciences (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 11119, p 11119 (2021)
A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4-anilinoquinoline scaffold where the primary sulphonamide functionality was grafted at C4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e564ecc7c9b394c6fdfe060d1b22a0
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