The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1/Nrf2, and NLRP3 inflammasome.

Autor: Rofaeil RR; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt. remon.roufeal@mu.edu.eg.; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt. remon.roufeal@mu.edu.eg., Mohyeldin RH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Sharata EE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia, 61111, Egypt., Attya ME; Department of Pathology, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Essawy H; Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Ibrahim OA; Department of Obstetrics & Gynecology, Faculty of Medicine, Minia University, Minia, 61519, Egypt., Abdelzaher WY; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia, 61519, Egypt.

Publikováno v: Scientific reports [Sci Rep] 2024 Aug 19; Vol. 14 (1), pp. 19171. Date of Electronic Publication: 2024 Aug 19.

Aprepitant boasted a protective effect against olanzapine-induced metabolic syndrome and its subsequent hepatic, renal, and ovarian dysfunction; Role of IGF 1 /p-AKT/FOXO 1 and NFκB/IL-1β/TNF-α signaling pathways in female Wistar albino rats.

Autor: Mohyeldin RH; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: reham.hassan@deraya.edu.eg., Abdelzaher WY; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: walaa.hamada@mu.edu.eg., Sharata EE; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: ehab.essam@deraya.edu.eg., Mohamed HMA; Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia 61519, Egypt., Ahmed MYM; Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia 61519, Egypt., Attia JZ; Department of Anesthesia and I.C.U, Faculty of Medicine, Minia University, Minia 61519, Egypt., Atta M; Department of Anatomy, Faculty of Medicine, Minia University, Minia 61519, Egypt., Saleh RK; Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: Rabeh.Saleh@mu.edu.eg., Ghallab EA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: elshimaa.amir@deraya.edu.eg., Marey H; Department of Biochemistry, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: heba.ebrahim@mu.edu.eg., Elrehany MA; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: Mahmoud.elrehany@deraya.edu.eg., Rofaeil RR; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt; Department of Medical Pharmacology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: remon.roshdy@deraya.edu.

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2024 Mar; Vol. 221, pp. 116020. Date of Electronic Publication: 2024 Jan 17.

Role of EGF/ERK1/2/HO-1 axis in mediating methotrexate induced testicular damage in rats and the ameliorative effect of xanthine oxidase inhibitors.

Autor: Rofaeil RR; Department of Pharmacology, Minia University, Minia, Egypt.; Department of Pharmacology, Deraya University, New Minia, Minia, Egypt., Ibrahim MA; Department of Pharmacology, Minia University, Minia, Egypt., Mohyeldin RH; Department of Pharmacology, Deraya University, New Minia, Minia, Egypt., El-Tahawy NF; Department of Histology and Cell Biology, Minia University, Minia, Egypt., Abdelzaher WY; Department of Pharmacology, Minia University, Minia, Egypt.

Publikováno v: Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2023 Oct; Vol. 45 (5), pp. 511-520. Date of Electronic Publication: 2023 Mar 08.

The IL-6/HO-1/STAT3 signaling pathway is implicated in the amelioration of acetaminophen-induced hepatic toxicity: A neonatal rat model.

Autor: Rofaeil RR; Department of Pharmacology, Faculty of Medicine, 68877Minia University, Minia, Egypt.; Department of Pharmacology, Deraya University, New Minia City, Egypt., Welson NN; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, 158411Beni-Suef University, Beni-Suef, Egypt., Fawzy MA; Department of Biochemistry, Faculty of Pharmacy, 68877Minia University, Minia, Egypt., Ahmed AF; Department of Histology and Cell Biology, Faculty of Medicine, 68877Minia University, Minia, Egypt.; Department of Histology and Cell Biology, Misr University for Science and Technology, October City, Egypt., Atta M; Department of Anatomy, Faculty of Medicine, 68877Minia University, Minia, Egypt., Bahaa El-Deen MA; Department of Pediatric, Faculty of Medicine, 68877Minia University, Minia, Egypt., Abdelzaher WY; Department of Pharmacology, Faculty of Medicine, 68877Minia University, Minia, Egypt.

Publikováno v: Human & experimental toxicology [Hum Exp Toxicol] 2023 Jan-Dec; Vol. 42, pp. 9603271231151376.

Leukotriene Receptor Antagonist, Montelukast Ameliorates L-NAME-Induced Pre-eclampsia in Rats through Suppressing the IL-6/Jak2/STAT3 Signaling Pathway.

Autor: Abdelzaher WY; Department of Pharmacology, Faculty of Medicine, Minia University, Minia 61511, Egypt., Mostafa-Hedeab G; Pharmacology Department, Medical College, Jouf University, Sakaka 11564, Saudi Arabia.; Pharmacology Department, Faculty of Medicine, Beni-Suef University, Beni Suef 62511, Egypt., Bahaa HA; Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia 61511, Egypt., Mahran A; Department of Obstetrics and Gynecology, Faculty of Medicine, Minia University, Minia 61511, Egypt., Atef Fawzy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61511, Egypt., Abdel Hafez SMN; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia 61511, Egypt., Welson NN; Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni Suef 62511, Egypt., Rofaeil RR; Department of Pharmacology, Faculty of Medicine, Minia University, Minia 61511, Egypt.; Department of Pharmacology, Deraya University, New Minia 61111, Egypt.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Jul 24; Vol. 15 (8). Date of Electronic Publication: 2022 Jul 24.