Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Roelof J. C. Kluin"'
Autor:
Christel F. A. Ramirez, Daniel Taranto, Masami Ando-Kuri, Marnix H. P. de Groot, Efi Tsouri, Zhijie Huang, Daniel de Groot, Roelof J. C. Kluin, Daan J. Kloosterman, Joanne Verheij, Jing Xu, Serena Vegna, Leila Akkari
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Myeloid cells are abundant and plastic immune cell subsets in the liver, to which pro-tumorigenic, inflammatory and immunosuppressive roles have been assigned in the course of tumorigenesis. Yet several aspects underlying their dynamic alter
Externí odkaz:
https://doaj.org/article/8fdb0db866fb4b6fba788951b3b0d68b
Autor:
Yuwei Wang, Gwen M. H. E. Dackus, Efraim H. Rosenberg, Sten Cornelissen, Leonora W. de Boo, Annegien Broeks, Wim Brugman, Terry W. S. Chan, Paul J. van Diest, Michael Hauptmann, Natalie D. ter Hoeve, Olga I. Isaeva, Vincent M. T. de Jong, Katarzyna Jóźwiak, Roelof J. C. Kluin, Marleen Kok, Esther Koop, Petra M. Nederlof, Mark Opdam, Philip C. Schouten, Sabine Siesling, Charlaine van Steenis, Adri C. Voogd, Willem Vreuls, Roberto F. Salgado, Sabine C. Linn, Marjanka K. Schmidt
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background Due to the abundant usage of chemotherapy in young triple-negative breast cancer (TNBC) patients, the unbiased prognostic value of BRCA1-related biomarkers in this population remains unclear. In addition, whether BRCA1-related bio
Externí odkaz:
https://doaj.org/article/ddff242b9c864f39864f3885aee7bad4
Autor:
Roelof J. C. Kluin, Kristel Kemper, Thomas Kuilman, Julian R. de Ruiter, Vivek Iyer, Josep V. Forment, Paulien Cornelissen-Steijger, Iris de Rink, Petra ter Brugge, Ji-Ying Song, Sjoerd Klarenbeek, Ultan McDermott, Jos Jonkers, Arno Velds, David J. Adams, Daniel S. Peeper, Oscar Krijgsman
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Mouse xenografts from (patient-derived) tumors (PDX) or tumor cell lines are widely used as models to study various biological and preclinical aspects of cancer. However, analyses of their RNA and DNA profiles are challenging, bec
Externí odkaz:
https://doaj.org/article/6434550c4ed14fcc9809b0f01e508946
Autor:
Lorenza Mittempergher, Anna M Piskorz, Astrid J Bosma, Magali Michaut, G Bea A Wisman, Roelof J C Kluin, Marja Nieuwland, Wim Brugman, Kevin J W van der Ven, Francesco Marass, James Morris, Nitzan Rosenfeld, Mercedes Jimenez-Linan, Steven de Jong, Ate G J van der Zee, James D Brenton, René Bernards
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0235766 (2020)
High-grade serous ovarian carcinoma (HGSOC) remains the deadliest form of epithelial ovarian cancer and despite major efforts little improvement in overall survival has been achieved. Identification of recurring "driver" genetic lesions has the poten
Externí odkaz:
https://doaj.org/article/7f3ef9cdd1cd4ff0870e2b1e963d3724
Autor:
Leonora W. de Boo, Katarzyna Jóźwiak, Heikki Joensuu, Henrik Lindman, Susanna Lauttia, Mark Opdam, Charlaine van Steenis, Wim Brugman, Roelof J. C. Kluin, Philip C. Schouten, Marleen Kok, Petra M. Nederlof, Michael Hauptmann, Sabine C. Linn
BackgroundThe addition of adjuvant capecitabine to standard chemotherapy of early-stage triple-negative breast cancer (TNBC) patients has improved survival in a few randomised trials and in meta-analyses. However, many patients did not benefit. We ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d5aae5b49887e291215b9d10757ac1
http://hdl.handle.net/10138/343740
http://hdl.handle.net/10138/343740
Publikováno v:
Murphy, C, Naderlinger, E, Mater, A, Kluin, R J C & Wilmes, A 2023, ' Comparison of human recombinant protein coatings and fibroblast-ECM to Matrigel for induced pluripotent stem cell culture and renal podocyte differentiation ', ALTEX, vol. 40, no. 1, pp. 141-159 . https://doi.org/10.14573/altex.2112204
ALTEX, 40(1), 141-159. Spektrum, Akad. Verl., Springer Science + Business
ALTEX, 40(1), 141-159. Spektrum, Akad. Verl., Springer Science + Business
Human induced pluripotent stem cells (hiPSCs) offer great opportunities within the 3R framework. In the field of toxicology, they may contribute greatly to the reduction and eventually replacement of animal models. However, culturing hiPSCs as well a
Autor:
Philip C, Schouten, Lisa, Richters, Daniel J, Vis, Stefan, Kommoss, Ewald, van Dijk, Corinna, Ernst, Roelof J C, Kluin, Frederik, Marmé, Esther H, Lips, Sandra, Schmidt, Esther, Scheerman, Katharina, Prieske, Carolien H M, van Deurzen, Alexander, Burges, Patricia C, Ewing-Graham, Dimo, Dietrich, Agnes, Jager, Nikolaus, de Gregorio, Jan, Hauke, Andreas, du Bois, Petra M, Nederlof, Lodewyk F, Wessels, Eric, Hahnen, Philipp, Harter, Sabine C, Linn, Rita K, Schmutzler
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(23)
Previously, we developed breast cancerThe detection rate of theThe newly trained classifiers detected most
Autor:
Christoffer Flensburg, Tobias Sargeant, Astrid Bosma, Roelof J. C. Kluin, Robby E. Kibbelaar, Mels Hoogendoorn, Warren S. Alexander, Andrew W. Roberts, René Bernards, Daphne de Jong, Ian J. Majewski
Follicular lymphoma (FL) is typically a slow growing cancer that can be effectively treated. Some patients undergo transformation to diffuse large B cell lymphoma (DLBCL), which is frequently resistant to chemotherapy and is generally fatal. Targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5d18ae3bd0cfac5b735f54bc523284
https://doi.org/10.1101/181792
https://doi.org/10.1101/181792
Autor:
Ian J, Majewski, Irma, Kluijt, Annemieke, Cats, Thomas S, Scerri, Daphne, de Jong, Roelof J C, Kluin, Samantha, Hansford, Frans B L, Hogervorst, Astrid J, Bosma, Ingrid, Hofland, Marcel, Winter, David, Huntsman, Jos, Jonkers, Melanie, Bahlo, René, Bernards
Publikováno v:
The Journal of pathology. 229(4)
Diffuse gastric cancers typically present as late-stage tumours and, as a result, the 5 year survival rate is poor. Some gastric cancers are hereditary and these tend to be of the diffuse type; 30-40% of hereditary diffuse gastric cancers (HDGCs) can
Autor:
David M Vossen, Caroline V M Verhagen, Reidar Grénman, Roelof J C Kluin, Marcel Verheij, Michiel W M van den Brekel, Lodewyk F A Wessels, Conchita Vens
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206632 (2018)
BACKGROUND:Large cancer genome studies continue to reveal new players in treatment response and tumorigenesis. The discrimination of functional alterations from the abundance of passenger genetic alterations still poses challenges and determines DNA
Externí odkaz:
https://doaj.org/article/1ece493379cf446194cdc3f9516511b8